Ivo Röwekamp
A5092500323- Gut microbiota and health
- Immune Cell Function and Interaction
- Tryptophan and brain disorders
- Long-Term Effects of COVID-19
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
Charité - Universitätsmedizin Berlin
2023-2024
Humboldt-Universität zu Berlin
2023-2024
Freie Universität Berlin
2023-2024
Abstract The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression inflammatory responses associate with alterations in microbiome metabolome, we analyzed metagenome, cytokine, transcriptome profiles repeated samples from hospitalized patients uninfected controls, leveraged information post-hoc confounder analysis. Severe was associated a depletion beneficial intestinal microbes, whereas oropharyngeal microbiota disturbance mainly...
IL-22 plays a critical role in defending against mucosal infections, but how production is regulated incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild-type animals and single-nucleotide polymorphisms IL33 IL1RL1 associated with pneumococcal pneumonia humans. The effect of on S. was mediated by negative regulation innate lymphoid cells (ILCs) independent ILC2s as well IL-4 IL-13...
Diabetes mellitus is associated with an increased risk of pneumonia, often caused by so-called typical and atypical pathogens including Streptoccocus pneumoniae Legionella pneumophila, respectively. Here, we employed a variety mouse models to investigate how diabetes influences pulmonary antibacterial immunity. Following intranasal infection S. or L. type 2 diabetic prediabetic mice exhibited higher bacterial loads in their lungs compared control animals. Single cell RNA sequencing, flow...
ABSTRACT IL-22 plays a critical role in defending against mucosal infections, but how production is regulated incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild-type animals, and single nucleotide polymorphisms IL33 IL1RL1 associated with pneumococcal pneumonia humans. The effect of on S. was mediated by negative regulation innate lymphoid cells (ILCs), independent ILC2s as well...
Abstract The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression inflammatory responses associate with alterations in microbiome metabolome, we analyzed metagenome, cytokine, transcriptome profiles repeated samples from hospitalized patients uninfected controls, leveraged information post-hoc confounder analysis. Severe was associated a depletion beneficial intestinal microbes, whereas oropharyngeal microbiota disturbance mainly...