A5043232091- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Pelvic floor disorders treatments
- Ureteral procedures and complications
- Renal and Vascular Pathologies
- Urinary Bladder and Prostate Research
- Pelvic and Acetabular Injuries
- Cancer Immunotherapy and Biomarkers
- DNA and Nucleic Acid Chemistry
- Anorectal Disease Treatments and Outcomes
- Organ Donation and Transplantation
- Pediatric Urology and Nephrology Studies
- Metastasis and carcinoma case studies
- Infectious Aortic and Vascular Conditions
- Diversity and Career in Medicine
- Urological Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Medical History and Research
- Diverticular Disease and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Hernia repair and management
- Bacterial Genetics and Biotechnology
Charité - Universitätsmedizin Berlin
2015-2025
Freie Universität Berlin
2018-2025
Humboldt-Universität zu Berlin
2018-2025
Klinik und Poliklinik für Urologie
2018
Ludwig-Maximilians-Universität München
2015
University of Würzburg
2007
Weizmann Institute of Science
1984-1990
Israel Institute for Biological Research
1980-1982
Bar-Ilan University
1980-1982
Island Hospital
1940
The transcription factor GATA binding protein 3 (GATA3) is commonly used in surgical pathology as a diagnostic marker to distinguish urothelial carcinomas from other cancer entities. However, the clinical relevance of GATA3 expression bladder not completely clarified. In this study, we investigated immunostaining on 2710 tissue microarray platform by using two different antibodies better understand its impact relation pathological parameters disease progression and patient outcome. Nuclear...
Quantity and the spatial relationship of specific immune cell types can provide prognostic information in bladder cancer. The objective study was to characterize interplay role different subpopulations
Abstract Purpose The objective of this study was to evaluate the perioperative outcomes and complications associated with use acetylsalicylic acid (ASA) in deceased donor kidney transplantation (KTX), a particular focus on bleeding events. Methods We retrospectively analyzed 157 transplant recipients (KTRs) who underwent KTX at Charité Berlin, Department for Urology, between February 2014 December 2017. Patients were divided into two groups: patients ASA their preoperative medication (Group...
We aimed to assess the impact of GATA3 binding protein (GATA3) gene copy number alterations on tumor aggressiveness, patient prognosis, and expression in a large urothelial bladder cancer cohort. A tissue microarray containing over 2,700 cancers (pTa-pT4) was analyzed retrospectively using dual-labeling fluorescence in-situ hybridization (FISH) with probes for (10p14) centromere 10. gains were categorized as elevation (ratio GATA3/centromere ≥ 2/≤4), low-level amplification > 4/≤12),...
Background/Objectives: Audio and audiovisual distraction can be effective additive tools to reduce anxiety pain in patients receiving outpatient procedures (OP). Audiovisual already showed positive effects on perception some urological procedures. To identify the of audio perineal prostate biopsy (PPB), we performed a prospective randomized controlled study. Methods: We recruited 168 male undergoing PPB which were into three groups: control group (CG), an (ADG) (AVDG). The CG received no...
Abstract Background Loss of chromosome Y (LOY) has recently been proposed to be associated with cancer aggressiveness, altered T-cell function, and poor prognosis in bladder carcinomas. Methods Chromosome was analyzed using fluorescence in-situ hybridization on a tissue microarray containing 2,071 urothelial carcinomas the urinary from male patients, including 487 patients who had undergone cystectomy for muscle-invasive disease whom follow-up data were available. Data tumor microenvironment...
Abstract STING is a key element in the cGAS/STING cytosolic DNA sensing pathway which can stimulate immune response through type I interferon (IFN) production. Numerous agonists are currently evaluated for their suitability as anticancer drugs. Most previous studies focused on expression inflammatory cells, but also be expressed cancer cells. To evaluate potential clinical significance of bladder was analyzed by immunohistochemistry more than 2,500 urothelial carcinomas tissue microarray...
Abstract Loss of S-methyl-5′-thioadenosine phosphorylase (MTAP) expression offers an important therapeutic option through synthetic lethality with inhibitors targeting related pathways, and has been linked to resistance immune checkpoint in several tumor types. To better understand the prevalence clinical relevance MTAP prostate cancer, a tissue microarray 17, 747 cancer samples molecular database was analyzed for by immunohistochemistry. Normal glands showed weak moderate, predominantly...
Carcinoembryonic antigen (CEA) is a cell surface glycoprotein that represents promising therapeutic target. Serum measurement of shedded CEA can be utilized for monitoring cancer patients.
Cytokeratin 20 (CK20) expression is limited to umbrella cells in the normal urothelium. Since CK20 often upregulated neoplastic urothelial including dysplasia and carcinoma situ, immunohistochemical analysis used for assessment of bladder biopsies. a feature luminal cancer subtype, but its prognostic relevance disputed. In this study, we investigated on >2700 carcinomas tissue microarray format by immunohistochemistry. Cytoplasmic membranous staining was seen 1319 (51.8%) cancers. The...
Incomplete P2Y(12)-inhibition during clopidogrel treatment is associated with increased cardiovascular events and mortality after coronary intervention. We investigated the incidence of impaired individual clopidogrel-responsiveness using a P2Y(12)-specific pre-treatment-independent assay in real world situation. One hundred consecutive patients artery disease (CAD) on combined acetylsalicylic acid (75 mg/d) 33 aspirin only were screened for platelet ADP-induced signalling by conventional...
Most inactivating p53 mutations result in a nuclear accumulation - detectable by immunohistochemistry (IHC). alterations leading to complete lack of protein and absence immunostaining do also occur not easily IHC. p16 is upregulated inactivated cells. We hypothesized that positive IHC may help distinguish inactivation negative cases.We investigated on 2710 urothelial bladder carcinomas tissue microarray format understand their impact relation clinicopathological parameters disease...
Abstract Binding of chromomycin A 3 (CRA) to calf thymas DNA was investigated in the presence divalent cations using visible absorption and 1 H‐nmr spectroscopies. An apparent equilibrium binding constant (∼ 10 11 M −1 ) obtained from metal competition experiments EDTA remove cation DNA–M–CRA (M: metal) complex. The large drug enabled us obtain essentially complete complexation CRA short homogeneous d(ATGCAT) 2 duplex stoichiometric amounts cation. Large induced chemical shifts were observed...
Abstract Purpose Management of a failed kidney allograft, and the question whether it should be removed is challenging task for clinicians. The reported risks transplant nephrectomy (TN) vary, there no clear recommendation on indications or surgical approach that used. This study gives an overview indications, compares techniques, identifies risk factors higher morbidity. Methods Retrospective analysis was conducted all nephrectomies performed between 2005 2020 at Charité Hospital Berlin,...
Abstract Background A high level of PD-L1 expression is the most relevant predictive parameter for response to immune checkpoint inhibitor (CPI) therapy in urinary bladder cancer. Existing data on relationship between and natural course disease are controversial sparse. Methods To expand our understanding parameters cancer aggressiveness, was analyzed tissue microarrays containing 2710 urothelial carcinomas including 512 patients with follow-up who underwent radical cystectomy therapies...
Zusammenfassung Hintergrund Der Fachkräftemangel in der Medizin stellt eine drängendsten Herausforderungen im Gesundheitswesen dar. Die steigende Anzahl von Frauen und Speziellen dem Fachbereich Urologie wirft Fragen zur Vereinbarkeit Familie Beruf auf, insbesondere Bezug auf die Arbeitsumgebung Arbeitszeitmodelle. Ziel Arbeit ist es, Auswirkungen Mutterschaft das Berufsleben Ärztinnen Wissenschaftlerinnen Deutschland zu erfassen. Dabei sollen spezifische diesem chirurgischen Fachgebiet...
Background: The onabotulinumtoxinA detrusor injection (OnabotA DI) was approved a decade ago for the treatment of patients with idiopathic overactive bladder (iOAB) or neurogenic overactivity (nDO) dysfunction who had not been treated successfully otherwise. procedure is usually performed under local anesthesia (LA), and various approaches have investigated to make as painless possible. We examined level anxiety pain experienced by wanted LA general (GA). Material Methods: Patients scheduled...
Abstract Homozygous 9p21 deletions usually result in a complete loss of S‐methyl‐5′‐thioadenosine phosphorylase (MTAP) expression visualizable by immunohistochemistry (IHC). MTAP deficiency has been proposed as marker for predicting targeted treatment response. A tissue microarray including 2,710 urothelial bladder carcinomas were analyzed deletion fluorescence situ hybridization and IHC. Data compared with data on tumor phenotype, patient survival, intratumoral lymphocyte subsets, PD‐L1...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrdered DNA-polypeptide complexes of extreme chirality: effects polypeptide handedness on DNA long-range asymmetrySarah. Weinberger, Craig. Berman, and Abraham. MinskyCite this: J. Am. Chem. Soc. 1988, 110, 24, 8231–8232Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ja00232a043https://doi.org/10.1021/ja00232a043research-articleACS...