A5073911376- Statistical Methods in Clinical Trials
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Mycobacterium research and diagnosis
- Lung Cancer Diagnosis and Treatment
- Pain Management and Placebo Effect
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inhalation and Respiratory Drug Delivery
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal and related cancers
- Health Systems, Economic Evaluations, Quality of Life
- Pain Management and Opioid Use
- Biochemical effects in animals
- CAR-T cell therapy research
- NF-κB Signaling Pathways
- Renal cell carcinoma treatment
- Respiratory Support and Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Anesthesia and Neurotoxicity Research
- Anorectal Disease Treatments and Outcomes
- Lymphoma Diagnosis and Treatment
- Meta-analysis and systematic reviews
National Institutes of Health
1985-2022
National Cancer Institute
2022
Keio University Hospital
2019
Memorial Hospital
2017-2019
University of Occupational and Environmental Health Japan
2016-2019
Max Planck Institute of Immunobiology and Epigenetics
2014
MedStar Washington Hospital Center
2014
Hyogo Medical University
2003-2007
Osaka University
2007
Kyoto University
2004
8511 Background: Dramatic responses to MET inhibitors have been reported in patients with NSCLC harboring activating mutations that cause exon 14 ( METdel14) skipping. We conducted a multicenter retrospective analysis of pts METdel14 determine if treatment impacts survival. Methods: collected clinicopathologic data on NSCLC. Event-time distributions were estimated using Kaplan-Meier and compared the log-rank test. Multivariable Cox models fitted estimate hazard ratios. Results: Of 148 mutant...
ABSTRACT The Wilms' tumor gene WT1 is overexpressed in various kinds of hematopoietic malignancies as well solid cancers, and this protein has been demonstrated to be an attractive target antigen for cancer immunotherapy. WT1‐specific CTL epitopes with a restriction HLA‐A*2402 or HLA‐A*0201 have already identified. In the present study it that 9‐mer WT1‐derived 187 peptide, which had shown elicit response HLA‐A*0201, can also HLA‐A*0206. all three different HLA‐A*0206 + healthy donors...
2552 Background: The primary objective of phase I clinical trials is to evaluate the tolerability and pharmacokinetics a new agent. Phase in oncology remain ethically controversial. Our previous analysis from year 1991 through 2002 reported response rate 10.6 percent toxicity-related death 0.49 percent. An increasing number molecular targeted agents are under investigation these results may not reflect current trials. Methods: We reviewed all non-pediatric 1 sponsored by Cancer Therapy...
A variety of lung disorders are associated with the accumulation eosinophils in alveolar structures. To help understand role these disorders, an animal model eosinophilic disease was developed. Administration aerosol polymyxin B to guinea pigs (3 times per wk for 4 wk) produced diffuse interstitial wall thickening and alveolitis characterized by marked increases macrophages. Bronchoalveolar lavage confirmed presence significantly increased numbers macrophages polymyxin-B-treated animals...
Mice lacking the lymphocyte-specific transcription factor Bob1 (also called OBF-1 or OCA-B) fail to generate germinal centers and a robust Ig response. We show that peripheral B cells in Bob1(-/-) mice bear characteristics of chronically activated anergic-like identify immunosuppressive microRNA-146a, together with other microRNAs, as novel transcriptional targets Bob1. The inability restrict cell signaling could contribute immunodeficient phenotype these is consistent an important role for...
PURPOSE Cancer drug development has largely shifted from cytotoxic chemotherapy to targeted treatment in the past two decades. Although previous studies have highlighted improvement response rates recent phase I trials, disease-focused reporting is limited. METHODS We integrated patient-level data for patients with hematologic malignancies who participated trials sponsored by National Institute Therapy Evaluation Program between January 2000 and May 2019 estimated trend of grade 5 toxicity...
Endobronchial ultrasonography with a guide sheath (EBUS-GS) has recently been used for improved diagnostic yields peripheral pulmonary lesions. This study retrospectively evaluated the factors related to yield of EBUS-GS lung cancer. The medical records 76 patients who had diagnosed cancer and undergone bronchoscopy in our hospital between August 2014 September 2015 were reviewed. total ratio was 71.1%. following evaluated: location lesion; size; feature; bronchus sign; EBUS probe;...
To evaluate the role of laparoscopy in diagnosis and therapy infertility.Retrospective study.Academically affiliated reproductive endocrinology practice.One hundred seventy patients.Diagnostic/therapeutic laparoscopy.One infertile patients underwent diagnostic between 1996 2000 our clinic, 109 them were seen at follow-up more than 1 year after laparoscopy. Of patients, 77 (70.6%) treated with assisted technology, such as vitro fertilization-embryo transfer, 32 (29.4%) conventional...
An eighty-nine-year-old Japanese male was admitted to our hospital due dry cough and dyspnea.Respiratory symptoms appeared soon after an administration of oriental medicine, Kamikihito for tinnitus.Upon admission, chest computed tomography showed patchy consolidations ground-glass opacities in the right upper lobe lungs, bilateral lower lobes.Sulbactam-ampicillin combination (SBT/ ABPC, 3 g × 2/day) started addition change or cessation several other drugs, including Kamikihito, resulting...
Crohn's disease (CD) often accompanies with small intestinal lesion in addition to large lesion. Nutritional therapy, a standard therapy for pediatric CD US and Europe, has been applied on adult Japan. According the Japanese therapeutic guideline from Ministry of Health, Labour Welfare, first choice is nutritional dietary management, second drug treatment third surgical treatment. When accompanied treatment, superior remission rate luminal obtained. However we sometimes see little...