A5101538507- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Vascular Malformations Diagnosis and Treatment
- Phytoestrogen effects and research
- Bacteriophages and microbial interactions
- Retinoids in leukemia and cellular processes
- Growth Hormone and Insulin-like Growth Factors
- Synthesis and Reactions of Organic Compounds
- Hepatitis C virus research
- Biliary and Gastrointestinal Fistulas
- Acute Ischemic Stroke Management
- Older Adults Driving Studies
- GABA and Rice Research
- Whipple's Disease and Interleukins
- MRI in cancer diagnosis
- Meningioma and schwannoma management
Matsumoto City Hospital
2025
Teikyo University
2020
Nagoya University
1991-2018
Hiroshima University
1990-1997
OBJECTIVES: Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) has recently been reported as an alternative to percutaneous transhepatic biliary drainage (PTBD) in cases of obstruction, when endoscopic (EBD) is unsuccessful. However, prospective studies EUS-CDS have not yet performed. We conducted a study evaluate the safety, feasibility, and efficacy patients with malignant lower tract obstruction. METHODS: A confirm safety was carried out 6 patients, followed by trial...
The purpose of this study was to clarify the usefulness contrast-enhanced endoscopic ultrasonography in pancreatic diseases.The subjects comprised 37 patients with diseases: 11 ductal cell carcinoma, 10 mucin-producing tumor, five pseudo-cyst, four islet chronic pancreatitis, and three serous cystadenoma. After ultrasonography, Albunex (0.22 ml/kg) injected intravenously at a rate 1 ml/s into right median vein, observation continued for min. presence or absence enhancement lesion determined...
Abstract Eight patients with malignancies confined to the peritoneal space participated in this study. Five hundred milligrams 5-fluorouracil or 10 mg mitomycin C was diluted 1 L saline. The mixed solution injected intraperitoneally through semi-permanent catheter. Blood and fluid were collected after injection. 5-Fluorouracil concentrations 1000 times those serum, while 100 serum. Areas under concentration vs time curve (AUC) calculated by trapezoidal method extrapolation infinity. ratio of...
Only a few reports exist on the use of ethanol ablation for posthepatectomy bile leakage. The aim this study was to assess value in refractory leakage.Medical records consecutive patients who underwent first hepatobiliary resection with bilioenteric anastomosis between 2007 and 2016 were reviewed retrospectively, special attention leakage therapy. Bile graded as A/B1/B2 according International Study Group Liver Surgery definition. Absolute injected into target duct during fistulography.Of...
Effects of sodium chloride (NaCl) and ethanol on gastric tumor development in rats after treatment with N ‐methyl‐ N′ ‐nitro‐ ‐nitrosoguanidine (MNNG) were studied. MNNG, dissolved distilled water (5 g/liter), was administered orally once fay tube at a dose 0.25 ml/10 g body weight to 4‐week‐old ACI rats. After this carcinogen initiation, animals fed diet containing 10% NaCl (Group 2) or normal the drinking 4). MNNG alone 1), 3), 5), control 6) also maintained. All survivors killed one year...
Journal Article Increase in estrogen receptor levels MNU-induced thyroid tumors LE rats Get access Nariaki Fujimoto, Fujimoto Department of Cancer Research, Research Institute for Nuclear Medicine and Biology, Hiroshima University1-2-3 Kasumi, Minami-ku, 734, Japan Search other works by this author on: Oxford Academic PubMed Google Scholar Yoko Sakai, Sakai Akihiro Ito Carcinogenesis, Volume 13, Issue 8, August 1992, Pages 1315–1318, https://doi.org/10.1093/carcin/13.8.1315 Published: 01...
The succinic dehydrogenase inhibition (SDI) test has been widely used to evaluate the sensitivity of cancer cells anticancer agents. Recently, techniques for tissue culture have progressed; ability make formazan improved with use methylthiazol tetrazolium bromide (MTT) instead triphenyl chloride (TTC) in this assay. Therefore, we modified SDI order drug response gastrointestinal and applied it a clinical study. In assay, optimal concentration levels mytomycin-C Adriamycin materials are 10...
Aim: We investigated a protocol that lowered the necessary dose of anti‐hepatitis B surface immunoglobulin (HBIg) with frequent monitoring hepatitis antigen (HBsAg) and antibody (HBsAb) levels in early post‐transplant period. Methods: Fifteen virus (HBV)‐positive patients were studied. administered nucleoside analog from preoperative period, high HBIg was used intraoperatively (200 IU/kg who weighed less than 50 kg, 10 000 IU those more or equal to kg) continued every day (5000–10 IU/day)....
Aim: Studies of animal models have determined that liver regeneration after partial hepatectomy is mediated by a various cytokines. The aim the present study was to evaluate levels these cytokines and subsets circulating lymphocytes in healthy humans hepatectomy. Methods: Four individuals underwent for living‐related donor transplantation. We also evaluated comparison, three patients with myoma uteri who hysterectomy. Blood samples were obtained before surgery on postoperative days (PD) 1,...
MtT/F84 grew well in Fischer rats (F344), but tumor growth was promoted hyperestrogenized rats. Effects of dietary retinoic acid (RA) on growth, estrogen receptor (ER) and serum hormone (GH) level were examined. Tumor latency became shortened, take weight by all-trans RA at dosages 50 200 mg/kg basal diet, not dose-dependently. ER elevated RA-treated rats, whereas the acid-binding protein remained unchanged. also incorporation 5-bromo-2'-deoxyuridine, a thymidine analogue, into DNA cells....
The influence of sex hormones on induction intestinal rnetaplasia was examined in 5 week old Crj: CD (SD) rats both sexes. At the age 4 weeks, animals were gonadectornized and given testosterone or dimethyl estradiol (DES). One after operation, they irradiated with two 10 Gy doses X‐rays to gastric region at a 3 day interval for total 20 Gy. termination experiment, 6 months X‐irradiation, incidence metaplasia alkaline phosphatase (ALP) positive foci males significantly higher than females,...
Abstract Feasibility of utilizing human gastric cancers as first transplant generation xenografts in nude mice for determining tumor sensitivity to chemotherapeutic agents was demonstrated by applying subrenal capsule (SRC) assay. A total 55 tumors from patients were tested this Mitomycin‐C (MMC) and hexycarbamyl‐5‐FU (HCFU, 5‐FU derivative) selected the treatment these after surgery also assay transplant. Evaluable rate MMC 92.7% that HCFU 90.9%. Sensitivity 25% 32%. Correlation between...
Surgery of cerebral aneurysm confronts expected difficulty and unexpected happenings. To make difficult surgery easy, a surgical strategy as if operating in shallow basin with the skull base technique is required. Extradural drilling anterior clinoid process most basic to obtain wide working space by mobilizing internal carotid artery. We report case very high-positioned basilar top treated this technique. Drilling safe quick On contrary, posterior poses danger massive bleeding from venous...