Acute Lung Injury (ALI) is a life-threatening syndrome that has been identified as potential complication of COVID-19. There critical need to shed light on the underlying mechanistic pathways and explore novel therapeutic strategies. This study aimed examine effects Citrus clementine essential oil (CCEO) in treating potassium dichromate (PDC)-induced ALI. The chemical profile CCEO was created through GC–MS analysis. An vivo rats conducted evaluate effect administrated via two different...

Pancreatic cancer is one of the most serious and lethal human cancers with a snowballing incidence around world. The natural product celastrol has also been widely documented as potent anti-inflammatory, anti-angiogenic, anti-oxidant.To elucidate antitumor effect on pancreatic cells its modulatory role whole genome expression.The activity panel evaluated by Sulforhodamine B assay. Caspase 3/7 histone-associated DNA fragments assays were done for apoptosis measurement. Additionally,...

Despite the exploration of pharmaceutical and natural liver-protecting drugs, number hepatotoxicity deaths continues to rise. Milk thistle flavonoids, silymarin, have been widely investigated demonstrated liver disease protection. Poor solubility absorption restrict silymarin bioavailability. Effervescent formulations may boost by improving gastrointestinal solubility. Our study compared effectiveness effervescent formulation in protecting from thioacetamide (TAA)-induced oxidative damage at...

Food preservatives such as NaNO2, which are widely used in human food products, undoubtedly affect, to some extent, organs and health. For this reason, there is a need reduce the hazards of these chemical preservatives, by replacing them with safe natural bio-preservatives, or adding synthetic ones, provides synergistic additive effects. The Citrus genus rich source addition availability low price citrus fruit crops. In study, we identify most abundant flavonoids fruits (hesperidin) from...

Helicobacter pylori (H. pylori) is a global health threat, and the World Health Organization has included H. among 12 bacterial species that require high priority future strategies for development of new antibiotics due mainly to its rates resistance. Metallic nanoparticles are known their antimicrobial properties. The FDA (Food Drug Administration) approved zinc oxide (ZnONPs) as biocompatible antimicrobials. Green synthesis ZnONPs was performed based on Oak galls extract (OGE)...

Abstract: Background: Digestive cancer is among the major causes of mortality and morbidity worldwide. Rutin, a bioactive secondary metabolite belonging to flavonoids distributed in many fruits vegetables has shown anti-proliferative, anti-cancer, neuroprotective activities. In this study, antiproliferative, antioxidant apoptotic activities rutin on hepatic pancreatic cell lines were investigated. Materials Methods: The effect cellular viability was monitored by SRB assay. Increasing...

Background and Objective: Antibiotic resistance is rising to dangerous levels in all parts of the world.Metallic nanoparticles among them; silver zinc oxide (Ag ZnONPs) are powerful weapons for fighting microbial resistance.Present study was aimed at green synthesis using eggplant aqueous methanolic extract, evaluation their antimicrobial activity against different pathogenic Gram-positive Gram-negative bacteria fungi.Materials Methods: Preparation were performed by reduction both nitrate...

Almost one-third of all infectious diseases are caused by viruses, and these account for nearly 20% deaths globally. It is becoming increasingly clear that highly contagious viral infections pose a significant threat to global health economy around the world. The need innovative, affordable, safe antiviral therapies must. Zinc oxide nanoparticles novel materials low toxicity cost known their activity. genus Pelargonium was previously reported its antimicrobial In this work, zonale leaf...

Background: Cancer is a dangerous threat that creates extremely high rates of death and morbidity in various regions the world. Finding suitable therapeutics to improve cancer therapy while avoiding side effects critical. The most appropriate innovative therapeutics, which combine natural ingredients nanomaterials, can biological activity chemotherapeutics. Methods: Phenolic profiling using high-resolution mass spectrometry synthesis zinc oxide nanoparticles was achieved through reaction...

The current study aimed to evaluate the pharmacokinetics and neuroprotective effect of well-characterised berberine-bovine serum albumin (BBR-BSA) nanoparticles. BBR-BSA nanoparticles were generated by desolvation method. Entrapment efficiency, loading capacity, particle size, polydispersity index, surface morphology, thermal stability,

Three new [nilotinins M8‒M10 (1‒3)] and two known [tamarixinin A (4) gemin D (5)] ellagitannins seven simple phenolics [gallic acid (6), methyl gallate (7), 3,4-di-O-methylgallic (8), ellagic (9), 3-O-methylellagic (10), ferulate 3-O-sulphate (11), 7,4'-di-O-methylkaempferol (12)] were isolated from the halophytic plant Tamarix nilotica (Ehrenb.) Bunge (Tamaricaceae). Their structures determined based on intensive spectroscopic studies comparisons with reported data. Compounds 4, 6-8...

2 new flavonoid glycosides, kaempferol 3-<i>O</i>-(4″,6″-di-<i>O</i>-α-L-rhamnopyranosyl)-β-D-glucopyranoside (1) and quercetin (2), were isolated from the <i>n</i>-butanol soluble fraction of methanol extract (BF) <i>Astragalus abyssinicus</i> aerial parts, together with 3 known compounds, rutin (3), 3-<i>O</i>-β-D-rutinoside (4) 5,7,4′-trihydroxy-3′-methoxyisoflavone (5). The structures compounds characterized on basis UV, NMR negative ESI-MS analyses. BF showed in vitro weak antibacterial...

Nowadays the application of lipid nanoparticles as carriers for delivery anticancer drugs gained great attention in cancer therapy. Solid (SLNs) and cubic (cubosomes) are considered promising The comparison these two efficient drug docetaxel was our main goal this study. Both were prepared by hot melt homogenization technique followed measurement particle size, zeta potential, entrapment efficiency vitro release docetaxel. An advanced has been applied to measure from using small unilamellar...

Abstract Background Several plants have not been investigated for their endophytes, such as the medicinal plant Ficus carica which anticancer activity has confirmed. The endophyte Aspergillus neoniger was selected investigation of its metabolites since it exerted activities in preliminary screening assays. Results Bioactivity-guided chromatographic fractionation performed on endophytic extract and resulted identification asperazine A through spectroscopic analysis. Moderate cytotoxicity...

Oral cancer is one of the most common types. Many factors can express certain genes that cause proliferation oral tissues. Overexpressed were detected in patients; three highly impacted. FAP, FN1, and MMP1 targeted showed inhibition results silico by ginsenoside C Rg1. Approved drugs retrieved from DrugBank database. The docking scores show an excellent interaction between ligands macromolecules. Further molecular dynamics simulations binding stability proposed natural products. This work...

Globally, pathogenic microbes have reached a worrisome level of antibiotic resistance. Our work aims to identify and isolate the active components from bioactive Ficus retusa bark extract assess potential synergistic activity most major compounds' constituents with tetracycline against certain bacterial strains. The phytochemical screening an acetone F. using column chromatography led identification 10 phenolic components. interaction catechin chlorogenic acid as compounds was evaluated by...

Abstract Background The medicinal plant Ficus carica L., inhabiting southwest regions of Asia, is known for its wide ethnopharmacological applications. In traditional medicine, it has been applied as a treatment respiratory, gastrointestinal and cardiovascular disorders, among others. Recent studies confirmed antimicrobial anticancer activities the extract. To find out whether endophytes F. contribute to biological activities, aerial parts were isolated examined effects. Results species...

Purpose: : Polyvinyl alcohol-capped silver nanostructures (cAgNSs) were investigated in order to enhance the cytotoxicity, proapoptotic, and oxidant patterns of human laryngeal carcinoma Hep-2 cells by employing a 50 mT electromagnetic field (LEMF) for 30 min.Methods: Wet chemical reduction was used synthesize cAgNSs, after they had been capped with polyvinyl alcohol, specifically examined particle size analysis structural morphology.To visualize how may attach protein targets, molecular...

<title>Abstract</title> Cisplatin (Cisp) is a widely used cancer treatment that effective and frequently included in plans. Treatment plans use large doses of Cisp or cumulative dosages, however, may cause liver damage. This study investigated the protective effects Methylene Blue (Meth) against ‎cisplatin-induced hepatotoxicity male Wistar Albino rats. Rats were divided into four groups: control, cisplatin (CP, 8 mg/kg, IP), two Meth-‎treated groups (25 mg/kg 50 IP) with CP‎. administration...