A5044747383- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Neuroendocrine Tumor Research Advances
- Bariatric Surgery and Outcomes
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Organ Donation and Transplantation
- Abdominal Surgery and Complications
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Abdominal vascular conditions and treatments
- Cancer Research and Treatments
- Enhanced Recovery After Surgery
Iwate Medical University
2015-2024
The University of Tokyo
2013
Teikyo University
2013
Osaka University
2013
Kyushu University Beppu Hospital
2013
In a statement from the second International Consensus Conference for Laparoscopic Liver Resection, adult-to-adult laparoscopic donor surgery was earliest phase of development. It recommended that procedure be performed under institutional ethical approval and reporting registry.At our institute, we started laparoscopy-assisted hepatectomy (LADH) in 2007 changed to pure (PLDH) 2012. This study included 40 living donors who underwent LADH 14 live PLDH. We describe technical aspects outcomes...
Recent studies revealed that both disseminated tumor cells and noncancerous contributed to cancer progression cooperatively in the bone marrow. Here, RNA-seq analysis of marrow from gastric patients was performed identify prognostic markers for cancer.Bone samples eight (stages I IV: n = 4 each) were used analysis. Results validated through quantitative real-time PCR (qRT-PCR) HIST1H3D expression 175 marrow, 92 peripheral blood, 115 primary patients. miR-760 assayed using qRT-PCR 105 96...
Cancer relapse occurs with substantial frequency even after treatment curative intent. Here we studied drug-tolerant colonies (DTCs), which are subpopulations of cancer cells that survive in the presence drugs. Proteomic characterization DTCs identified stemness- and epithelial-dominant subpopulations, but functional screening suggested DTC formation was regulated at transcriptional level independent from protein expression patterns. We consistently found α-amanitin, an RNA polymerase II...
Despite of remarkable improvement postoperative 5-FU–based adjuvant chemotherapy, the relapse rate gastric cancer patients who undergo curative resection followed by chemotherapy remains substantial. Therefore, it is important to identify prediction markers for chemotherapeutic efficacy 5-FU. We recently identified NF-κB as a candidate biomarker in cancer. To evaluate biological significance context we analyzed NF-κB-dependent response upon 5-FU treatment cell lines. Seven genes induced an...
Here, we report a case of 68-year-old woman with cT4N0M1 (liver invasion and multiple lung metastases) metastatic renal cell carcinoma. We could carry out less invasive nephrectomy partial hepatectomy because nivolumab administration as second-line therapy reduced the primary tumor remarkably. To best our knowledge, this is first use before carrying surgery, histological findings showed pathological complete response.
Liver transplantation is often the only lifesaving option for acute liver failure (ALF); however, predictors of short-term mortality (death within one year) after living donor (LDLT) ALF have yet to be defined. We retrospectively collected patients ≥18 years old who underwent LDLT between 2010 and 2020 at 35 centers in Asia. Univariate multivariate logistic regression analyses were conducted identify clinical variables related establish a novel scoring system. The Kaplan-Meier method was...
Background: In a statement by the second International Consensus Conference for Laparoscopic Liver Resection (LLR), minor LLR was confirmed to be standard surgical practice, as it has become adopted an increasing proportion of surgeons. However, is unclear whether this applies more complex group patients suffering from cirrhosis. Therefore, aim retrospective study compare feasibility and safety hepatocellular carcinoma (HCC) between non-liver cirrhosis (NLC) liver (LC) at single high-volume...
Emphysematous cholecystitis (EC) is an uncommon variant of acute cholecystitis, which caused by secondary infection the gallbladder wall with gas-forming organisms. The mortality rate EC still as high 25%. Emergency surgical intervention indicated. Open cholecystectomy has been traditionally accepted a standard treatment for EC. We present case successfully treated laparoscopic surgery. Laparoscopic considered to be safe and effective when
As a procedure, major laparoscopic liver resection (LLR) remains in the exploration phase. Previous studies have assessed LLR en bloc, including hepatectomies of varying complexities; however, number segments alone does not convey complexity resection. This study aimed to assess operative outcomes procedures with more than one sectionectomy, and identify best procedure as first step when learning carry out order make safer, widely used procedure.We carried retrospective review 120...
Abstract Aim Laparoscopic liver resection (LLR) is increasingly carried out worldwide. However, there are concerns regarding ischemia‐reperfusion injury caused by pneumoperitoneum and the Pringle maneuver. It not clear whether perioperative use of glucocorticoids lowers risk hepatic in LLR as has been reported for open resection. The aim present study was to investigate role glucocorticoid improving function surgical outcomes after LLR. Methods In this double‐blind, randomized controlled...
To confirm the clinical significance of NF-κB and JNK protein expression from experimentally identified candidates for predicting prognosis patients with 5-FU treatment, we evaluated surgically removed specimens. A total 79 specimens were obtained 30 gastric 49 colorectal cancer who underwent R0 resection followed by postoperative based adjuvant chemotherapy. Immunohistochemical examinations on tissue microarrays (TMAs) revealed that significantly shorter time-to-relapse (TTR) in both...
<b><i>Introduction:</i></b> Autoimmune pancreatitis (AIP) is recognized as a disease with good prognosis that responds well to steroids, but the complication of pancreatic ductal adenocarcinoma (PDAC) in AIP rare condition. We report case PDAC encapsulated by tumor-forming type 1 AIP. <b><i>Case Presentation:</i></b> The patient, 65-year-old female, was found have high CA19-9 levels and mass diameter 30 mm on abdominal ultrasonography....
Hideki Kumagai, Akira Sasaki, Umemura, Yota Tanahashi, Takafumi Iwasaki, Hirokatsu Katagiri, Hiroyuki Nitta
The efficacy and safety of laparoscopic liver resections for tumors that are larger than 10 cm remain unclear. We developed a safe right hemihepatectomy giant using an anterior approach.Eighty patients who underwent between January 2011 December 2021 were divided into nongiant tumor group (n = 65) 15) comparison.The median operating time, amount blood loss, length postoperative hospital stay did not differ significantly the groups. sizes weights resected in group. A comparison 23) 12)...
The expression of gastrointestinal differentiation markers is associated with the tumorigenesis and prognosis digestive cancers. However, little known about significance marker profiles in patients extrahepatic cholangiocarcinoma (CCA), which classified as perihilar distal CCA. purpose this study was to clarify role CCA based on tumor location. We examined resected (n = 30) 54) CCAs immunohistochemical following markers: MUC2, MUC5AC, MUC6, CD10, CDX-2, cytokeratin 20. Expression scores were...
Abstract Background The use of standard chemotherapy regimens has changed the application chemosensitivity tests from all chemotherapy-eligible patients to those who have failed chemotherapy, which includes with highly advanced, relapsed, or chemoresistant tumors. Methods We evaluated a total 43 advanced primary and relapsed gastric cancers for based on drug dose response curves improve objectivity quality quantitative measurements. were classified seven expected patterns. Instead binary...