A5067893702- Pancreatic and Hepatic Oncology Research
- Analytical chemistry methods development
- Glycosylation and Glycoproteins Research
- Telomeres, Telomerase, and Senescence
- Advanced Chemical Sensor Technologies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Protein Tyrosine Phosphatases
- Cancer Research and Treatments
- RNA modifications and cancer
- Diet, Metabolism, and Disease
- Dye analysis and toxicity
- Electrochemical Analysis and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Psychoanalysis, Philosophy, and Politics
- Advanced Fluorescence Microscopy Techniques
- Ideological and Political Education
- Pancreatitis Pathology and Treatment
- Ocular Oncology and Treatments
- Educational Reforms and Innovations
- Graphene research and applications
- Parvovirus B19 Infection Studies
Kagawa University
2020-2024
Wenzhou Medical University
2020
Zhejiang Taizhou Hospital
2020
Nanjing University of Science and Technology
2017
Jilin University
2012-2013
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2013
In the present study, graphene–zinc oxide composites (G–ZnO) were prepared and applied to adsorption of Cu(II), Pb(II), Cr(III) from aqueous solutions. The synthesized characterized by X-ray diffraction transmission electron microscopy. Effects pH contact time studied in batch experiments. Kinetics, isotherms, thermodynamics also examined. Kinetics experiments indicated that processes could be simulated a pseudo-second-order model. experimental results equilibrium tested Langmuir Freundlich...
The dense stroma is one cause of poor efficacy T cell-mediated immunotherapy in pancreatic ductal adenocarcinoma (PDAC). Carbohydrate sulfotransferase 15 (CHST15) a proteoglycan-synthetic enzyme responsible for remodeling tumor stroma. Intra-tumoral injection CHST15 small interfering RNA (siRNA) has been shown to increase the tumor-infiltrating cells (TILs) patients with unresectable PDAC. However, mechanism underlying enhanced accumulation TILs not fully explored. Here, we demonstrate that...
We reported new magnetic microspheres as the adsorbent of estrogens. They were prepared by coating Fe3O4 particles with a composite made from titanium dioxide and graphene oxide (Fe3O4@TiO2/GO). The beads loaded into microfluidic chip used to adsorb estrone (E1), estradiol (E2), estriol (E3). estrogens then eluted methanol submitted high performance liquid chromatography (HPLC) determination. Effects sample volume, flow rate, pH value, eluent rate optimized. limits detection for in range...
Abstract Recent evidence indicates that RNA‐dependent RNA polymerase (RdRP) activity of human telomerase reverse transcriptase (hTERT) regulates expression target genes and is directly involved in tumor formation a telomere‐independent manner. Non‐canonical function hTERT has been considered as therapeutic for cancer therapy. We have previously shown phosphorylation at threonine 249 (p‐hTERT), which promotes RdRP activity, an indicator aggressive phenotype poor prognosis liver pancreatic...
Monolithic materials were synthesized in capillaries by situ polymerization with N-isopropylacrylamide, glycidyl methacrylate, and ethylene dimethacrylate as the monomers, methanol PEG porogens. With γ-alumina nanoparticles attached to surface of porous monolithic column via epoxide groups, a novel polymer monolith microextraction (PMME) material was prepared good mechanical stability high extraction capacity. SEM X-ray photoelectron spectroscopy employed characterize modified column,...
The relationship between Helicobacter pylori (H pylori) and body mass index (BMI) is still inconclusive. Not only the high rate of H infection but also increasing higher BMI levels are endangering Chinese today.The aim this research was to evaluate association different situations values or in healthy population. A total 39 091 individuals aged from 18 years 80 years, performed examination including a 13 C/14 C urease breath test (13 C-UBT), were included. Among them, 30 224 had one time...
Abstract Background Telomere dysfunction has been reported to be directly involved in carcinogenesis owing chromosomal instability and immortalization; however, the clinicopathological significance of telomeres remains controversial. We have shown that telomere shortening occurs normal-appearing duct cells at initiation then continues during progression pancreatic cancer. In this study, we determined prognostic value length (TL) cancer progression. Methods TL both cancer-associated...
Background/Aim: Immunohistochemical (IHC) staining has been routinely used to distinguish adenocarcinoma (ADC) and squamous cell carcinoma (SCC) of the lungs; however, it is challenging obtain an accurate diagnosis, especially for cases with discrepancies between IHC hematoxylin eosin (H&E) results. This study aimed clarify clinicopathological characteristics these discrepant cases. Patients Methods: Tissue microarray specimens from 321 patients ADC SCC were H&E thyroid transcription...
Limited intratumoral T-cell infiltration in pancreatic ductal adenocarcinoma (PDAC) is an obstacle to immunotherapy, yet the efficient approach enhance tumor-infiltrating T cells not fully established. Here, we show that tumor-specific knockdown of carbohydrate sulfotransferase 15 (CHST15), a tumor stromal proteoglycan-synthetic enzyme, suppresses growth T-cell-dependent manner murine model PDAC. Silencing tumoral CHST15 unexpectedly expanded CD4+ and CD8+ draining LN (TDLN), leading...
A novel magnetic adsorbent, microsphere functionalized with Cyanex272, has been successfully synthesized via a chemical bonding alkylation method. flow injection on-line preconcentration, micro-column packed the as-synthesized coupled UV-Vis spectrophotometric method was developed for determination of phenol at wavelength 270 nm. Various experimental parameters were optimized as follows: eluent (methanol), sample rate (1.4 mL min−1), volume mL), pH (5.0), and (2.2 min−1). Under optimum...
DOI: 10.1002/jssc.201300754 Monolithic materials were synthesized in capillaries by situ polymerization. With γ-Al2o3 nanoparticles attached to the surface of porous monolith via epoxide groups, a novel polymer microextraction material was prepared with good mechanical stability and high extraction capacity. The SEM micrographs clearly demonstrated that pores size microglobules modified smaller than those unmodified monolith, implying increased monolith. In addition, new method developed for...
Abstract Standardized pathological evaluation of the regression assessment neoadjuvant pancreatic cancer is necessary to improve prognostication and compare treatment outcomes in clinical trials. However, appropriate tissue sampling from surgically resected after therapy has not been elucidated. We compared tumor scores largest slide determined macroscopically or histologically. reviewed all slides macroscopic photos cut surfaces pancreas patients treated with chemotherapy (n = 137;...
Telomeres are tandem repeats of the TTAGGG sequence at chromosomal ends and afford protection against instability. To investigate contribution telomere dysfunction in meningiomas, here we estimate associations between length, tumor grade, proliferation index a series 14 archived samples, using quantitative-fluorescence situ hybridization, Ki67 immunostaining, pathological analysis. The number mitoses per 10 high-power fields (HPF) was higher grade III cases than I or II cases. Telomere...
Pancreatoblastoma is a rare malignant epithelial neoplasm of the pancreas that mainly occurs in children and involves abnormalities WNT/β-catenin pathway, such as CTNNB1 mutation. However, molecular adult pancreatoblastoma are not well known.An elderly man, who underwent elective distal pancreatectomy splenectomy, was referred to our hospital with mass tail pancreas. Histologically, lesion revealed proliferation clear, basophilic, cartilaginous tumor cells lymphatic metastasis. Each...
Recent studies have shown that D-allose, a rare sugar, elicits antitumor effects on different types of solid cancers, such as hepatocellular carcinoma, non-small-cell lung cancer, and squamous cell carcinoma the head neck. In this study, we examined D-allose proliferation human glioblastoma (GBM) lines (i.e., U251MG U87MG) in vitro vivo underlying mechanisms. treatment inhibited U87MG cells dose-dependent manner (3-50 mM). However, did not affect cycles or apoptosis these but significantly...
Distributed video coding is a new mode, and it can shift the computational complexity from encoder to decoder. That makes very suitable for wireless terminals with limited computing capabilities, memory power. This technology rapidly developing emerging applications such as surveillance, digital camera mobile telephony. paper summarizes distributed theory application perspective of basic principle, framework, key development trend. On basis these, this proposes several aspects that worthy...
e16310 Background: Carbohydrate sulfotransferase 15 (CHST15) is a proteoglycan biosynthetic enzyme and responsible for tumor matrix remodeling. Intratumoral injection of CHST15 siRNA was shown to increase tumor-infiltrating T cells in patients with pancreatic cancer the phase I/IIa study. However, mechanism underlying enhanced cell accumulation not fully explored. Here we investigated effect locally injected on modulating immune microenvironment mice. Methods: For vivo pharmacokinetics after...