A5022499595- Retinal Development and Disorders
- Phagocytosis and Immune Regulation
- Plant-Microbe Interactions and Immunity
- Immune Cell Function and Interaction
- Retinal Diseases and Treatments
- Plant Gene Expression Analysis
- Plant Molecular Biology Research
- Plant Pathogenic Bacteria Studies
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Plant nutrient uptake and metabolism
- Polysaccharides and Plant Cell Walls
- Soil Carbon and Nitrogen Dynamics
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Food Quality and Safety Studies
- Advanced Topics in Algebra
- Rings, Modules, and Algebras
- Legume Nitrogen Fixing Symbiosis
- Nonlinear Differential Equations Analysis
- Immune cells in cancer
- Algebraic structures and combinatorial models
- Fractional Differential Equations Solutions
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
Xinjiang Academy of Agricultural Sciences
2025
Cotton Research Institute
2022-2025
Chinese Academy of Agricultural Sciences
2022-2025
Northwest Normal University
2023-2024
Hebei Academy of Agriculture and Forestry Sciences
2022-2024
Minzu University of China
2024
Tianjin Medical University Cancer Institute and Hospital
2019-2024
Shanghai University of Traditional Chinese Medicine
2024
National Clinical Research
2024
Northwest A&F University
2005-2023
Transposable elements (TEs) and DNA repeats are commonly targeted by histone methylation to achieve epigenetic gene silencing. We isolated mutations in two Arabidopsis genes, AtMORC1 AtMORC6, which cause derepression of DNA-methylated genes TEs but no losses or methylation. AtMORC6 members the conserved Microrchidia (MORC) adenosine triphosphatase (ATPase) family, predicted catalyze alterations chromosome superstructure. The atmorc1 atmorc6 mutants show decondensation pericentromeric...
The Royal College of Surgeons (RCS) rat is a widely studied animal model retinal degeneration in which the inability pigment epithelium (RPE) to phagocytize shed photoreceptor outer segments leads progressive loss rod and cone photoreceptors. We recently used positional cloning demonstrate that gene Mertk likely corresponds dystrophy ( rdy ) locus RCS rat. In present study, we sought determine whether transfer retina would result correction RPE phagocytosis defect preservation subretinal...
To determine whether mice that are homozygous for a targeted disruption of the Mer receptor tyrosine kinase gene (mer(kd)) manifest retinal dystrophy phenotype similar to RCS rats, which carry mutation in orthologous MERTK:Eyes mer(kd) and C57BL/6 wild-type (WT) were examined by light electron microscopy, whole-eye rhodopsin measurement, Ganzfeld electroretinography (ERG).The showed rapid, progressive degeneration photoreceptors (PRs). Features common rats included absence or near phagosomes...
The RCS rat is a widely studied model of recessively inherited retinal degeneration. genetic defect, known as <i>rdy</i> (retinal dystrophy), results in failure the pigment epithelium (RPE) to phagocytize shed photoreceptor outer segment membranes. We previously used positional cloning and<i>in vivo</i> complementation demonstrate that<i>Mertk</i> gene for <i>rdy</i>. have now primary RPE cell culture system that site action <i>Mertk</i> and obtain functional evidence key role Mertk...
Abstract Magnesium chelatase (MgCh) catalyzes the insertion of magnesium into protoporphyrin IX, a vital step in chlorophyll (Chl) biogenesis. The enzyme consists 3 subunits, MgCh I subunit (CHLI), D (CHLD), and H (CHLH). CHLI is an ATPase that mediates catalysis. Previous studies on have mainly focused model plant species, its functions other species not been well described, especially with regard to leaf coloration metabolism. In this study, we identified characterized mutant strawberry...
Eukaryotes have hundreds of nearly identical 45S ribosomal RNA (rRNA) genes, each encoding the 18S, 5.8S, and 25S catalytic rRNAs. Because cellular demands for ribosomes protein synthesis vary during development, number active rRNA genes is subject to dosage control. In genetic hybrids, one manifestation control nucleolar dominance, an epigenetic phenomenon in which progenitor are repressed. For instance, Arabidopsis suecica , allotetraploid hybrid thaliana arenosa A. -derived selectively...
Mertk is a key phagocytic receptor in the immune, male reproductive, and visual systems. In retinal pigment epithelium, required for daily ingestion of photoreceptor outer segment (OS) tips. Loss function causes degeneration rats, mice, humans; however, little known about mechanism by which regulates phase epithelial (RPE) phagocytosis. To address this, authors sought proteins that associated with during OS phagocytosis.Lysates RPE-J cells challenged various times were immunoprecipitated...
Complex regulation of brain-derived neurotrophic factor (BDNF) governs its intricate functions in brain development and neuronal plasticity. Besides tight transcriptional control from multiple distinct promoters, alternative 3′end processing the BDNF transcripts generates either a long or short 3′untranslated region (3′UTR). Previous reports indicate that RNA sequence 3′UTRs differentially regulates production to accommodate activity changes, conceivably through differential interactions...
Inherited photoreceptor degenerations (IPDs) are the most genetically heterogeneous of Mendelian diseases. Many IPDs exhibit substantial phenotypic variability, but basis is usually unknown. Mutations in MERTK cause recessive IPD phenotypes associated with RP38 locus. We have identified a murine genetic modifier Mertk-associated degeneration, C57BL/6 (B6) allele which acts as suppressor. Photoreceptors degenerate rapidly Mertk-deficient animals homozygous for 129P2/Ola (129) allele, whereas...
Abstract Fragile X syndrome (FXS), caused by the loss of functional FMRP, is a leading cause autism. Neurons lacking FMRP show aberrant mRNA translation and intracellular signalling. Here, we identify that, in Fmr1 knockout neurons, type 1 adenylyl cyclase ( Adcy1 ) enhanced, to excessive production ADCY1 protein insensitivity neuronal stimulation. Genetic reduction normalizes ERK1/2- PI3K-mediated signalling, attenuates synthesis corrects dendritic spine abnormality mice. also ameliorates...
Endophytic fungi live in healthy plant tissues and organs are a major source of natural bioactive compounds. In this study, we found that an endophytic fungus, Talaromyces purpureogenus CEF642N, isolated from the cotton roots, suppressed Verticillium dahliae by up to 53% after 15 days confrontation culture. Genome sequencing CEF642N mass spectrometry study its metabolites were used identify primary antagonists. To further elucidate antagonistic mechanism, transcriptome analysis...
Mutations in the MERTK gene are responsible for retinal degeneration Royal College of Surgeons (RCS) rat and a cause human autosomal recessive retinitis pigmentosa (RP). This study reports identification functional analysis novel mutations to provide information regarding whether they causative severe rod-cone young patient.MERTK missense variants identified by single-strand conformational polymorphism (SSCP) sequence were introduced into expression constructs used transfect HEK293T cells....
Atmospheric nitrogen (N) deposition has caused concern due to its effects on litter decomposition in subtropical regions where N-fixing tree species are widespread. However, the effect of N plantations remains unclear. We investigated a 2-year treatment decomposition, microbial activity, and nutrient release two forests containing Alnus cremastogyne (AC, N-fixing) Liquidambar formosana (LF, non-N-fixing). The rate AC was faster than LF when there no experimental deposition. In AC, initial...
Previously, we have shown that loss of the histone 3 lysine 27 (H3K27) monomethyltransferases ARABIDOPSIS TRITHORAX-RELATED 5 (ATXR5) and ATXR6 (ATXR6) results in overreplication heterochromatin. Here show DNA damage extensive chromocenter remodeling into unique structures named "overreplication-associated centers" (RACs). RACs a highly ordered structure with an outer layer condensed heterochromatin, inner enriched variant H2AX, low-density core containing foci phosphorylated H2AX (a marker...
We reported new magnetic microspheres as the adsorbent of estrogens. They were prepared by coating Fe3O4 particles with a composite made from titanium dioxide and graphene oxide (Fe3O4@TiO2/GO). The beads loaded into microfluidic chip used to adsorb estrone (E1), estradiol (E2), estriol (E3). estrogens then eluted methanol submitted high performance liquid chromatography (HPLC) determination. Effects sample volume, flow rate, pH value, eluent rate optimized. limits detection for in range...
The yield and quality of goji (Lycium barbarum L.) fruit are heavily dependent on fertilizer, especially the availability nitrogen, phosphorus, potassium (N, P, K, respectively). In this study, we performed a metabolomic analysis response berry to nitrogen fertilizer levels using an Ultra Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS/MS) method. There was no significant difference in or commodity grade between N0 (42.5 g/plant), N1 (85 N2...
Let [Formula: see text] be a 2-torsion free unital generalized matrix algebra with center text], and linear mapping on satisfying the condition This paper is devoted to study of structure under some mild assumptions text]. We provide necessary sufficient conditions for in form ([Formula: text]), where mapping. Then we apply our results characterize mappings that are commutant preservers or double preservers.
Edwardsiella tarda is a Gram-negative, facultative anaerobic rod-shaped bacterium and the causative agent of systemic disease "Edwardsiellosis". It commonly prevalent in aquatic organisms with subsequent economic loss hence has attracted increasing attention from researchers. In this study, we investigated complete genome sequence highly virulent isolate SC002 isolated hatchlings Siamese crocodile. The consisted one circular chromosome length 3,662,469 bp 57.29% G+C content four novel...
Abstract Objective: Osteoarthritis (OA) is a progressive joint disease characterized by degeneration and destruction of articular cartilage. Arctiin (ARC) has been shown in many studies to have potential anti-inflammatory, anti-apoptotic, antioxidant effects various diseases. However, the mechanism which ARC exerts its protective OA not fully understood. Here, we explore plays role OA. Materials Methods: Mouse chondrocytes were isolated through toluidine blue staining collagen II...
Memory stem T cells (Tscm) have attracted attention because of their enhanced self-renewal, multipotent capacity, and anti-tumor capacities. However, little is known about Tscm in patients with renal clear cell carcinoma (RCC) the role Wnt signaling these cells. We evaluated from RCC concerning activation vitro explored mechanism preferential survival.Flow cytometry identified surface markers cytokines produced accumulated presence glycogen synthase kinase beta inhibitor TWS119. Apoptosis...