A5064307143- Animal Disease Management and Epidemiology
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
- Influenza Virus Research Studies
- Bacillus and Francisella bacterial research
- Malaria Research and Control
- Immune Cell Function and Interaction
- Viral Infections and Outbreaks Research
- T-cell and B-cell Immunology
- Hepatitis C virus research
- Respiratory viral infections research
- Vibrio bacteria research studies
- Pharmaceutical studies and practices
- Poxvirus research and outbreaks
- HIV Research and Treatment
- Xenotransplantation and immune response
- Travel-related health issues
- Herpesvirus Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Epigenetics and DNA Methylation
- Pharmaceutical Practices and Patient Outcomes
- interferon and immune responses
- RNA and protein synthesis mechanisms
Bernhard Nocht Institute for Tropical Medicine
2016-2024
Crescent University
2018
Holy Family Red Crescent Medical College
2018
German Center for Infection Research
2017
University of California, Davis
2013
Institut Pasteur
2008-2010
Department of Virology
2010
University Hospital Bonn
2008
University of Bonn
2008
and
Staphylococcus aureus is among the most common pathogens isolated from blood cultures in Ghana; yet epidemiology of infections rural settings poorly described. This study aims to investigate antimicrobial susceptibility and clonal diversity S. causing bloodstream two hospitals Ashanti Region, Ghana. Blood were performed for all febrile patients (≥37.5 °C) on hospital admission. Antibiotic testing isolates was carried out by VITEK 2 system. Multiplex polymerase chain reaction (PCR) used...
The epidemiology of pediatric febrile illness is shifting in sub-Saharan Africa, but malaria remains a major cause childhood morbidity and mortality. present study describes causes hospitalized children Ghana aims to determine the burden coinfections their association with parasite densities. In prospective study, (aged ≥30 days ≤15 years) fever ≥38.0°C were recruited after admission ward primary hospital Ghana. Malaria parasitemia was determined blood, stool, urine, respiratory,...
We evaluated phenotypic markers in full-genome sequences of avian influenza isolates to identify strains with increased potential for transmission and pathogenicity mammals. Of 149 examined, 67 were positive the consensus from 206 isolates. Analysis deep sequencing data a subset 24 revealed that 344 subpopulations occurred at marker positions. Markers significantly more likely be negative (258/344) than (86/344), but nearly all marker-positive (78/86) associated marker-negative sequences....
Abstract Zoonotic infectious diseases (ZIDs) are increasing globally, and livestock farmers in low‐ middle‐income countries at particularly high risk. An evaluation of farmer's behaviour on farms can be used to identify the risk factors develop tailored control strategies. This study documents knowledge zoonotic poultry (ZPD) among 152 farm workers (respondents) from 76 Ashanti region Ghana assessed their on‐farm attitude practices that increase exposure ZPD. The median age respondents was...
It was previously reported that a malaria infection may interfere with the specificity of commercial ELISA test against Zika virus (ZIKV). We analyzed 1,216 plasma samples from healthy, pregnant women collected in two sites Madagascar 2010 for ZIKV antibodies using and Plasmodium by PCR. This screen revealed six putative ZIKV-positive ELISA. These results could not be confirmed indirect immunofluorescence assays or neutralization tests. Four these were also positive P. falciparum. noted...
We report the complete genome sequence of a reassortant H14N2 avian influenza virus isolated in 2011 from northern shoveler California. This introduced Eurasian subtype acquired seven segments North American viruses and circulated Pacific Flyway 1 year after its detection Mississippi Flyway.
Abstract Influenza A viruses (IAVs) have both zoonotic and anthroponotic potential are of public veterinary importance. Swine intermediate hosts ‘mixing vessels’ for generating reassortants, progenies which may harbour pandemic propensity. handlers at the highest risk becoming infected with IAVs from swine but there is little information on ecology human–animal interface in Africa. We analysed characterized nasal throat swabs farmers respectively, using RT‐qPCR, farms Ashanti region, Ghana....
In patients with hepatitis C, a loss-of-function mutation of chemokine receptor CCR5 (CCR5Delta32) has been shown to be associated spontaneous viral clearance and lower levels hepatic inflammation. the present study, we show that is coexpressed inhibitory NKG2A on CD8(+) T cells. Consequently, CCR5(+) cells were highly susceptible NKG2A-mediated inhibition cytotoxic activity NKG2A(+) lymphocytes preferentially attracted by ligands induced C virus E2 antigen. Thus, likely exert...
The German Biosecurity Programme was launched in 2013 with the aim to support partner countries overcome biological threats including natural outbreaks or intentional misuse of highly pathogenic agents. As part this programme, paper describes development and implementation a multilateral biosafety biosecurity training initiative, called 'Global Partnership Initiated Academia for Controlling Health Threats' (GIBACHT). To achieve its objectives, GIBACHT implemented blended-learning approach...
For an analysis of the prevalence influenza A viruses (IAVs) circulating in chickens and their farmers Ashanti region, Ghana, we examined 2,400 trachea cloaca swabs (chickens) 102 oropharyngeal (farmers) by qRT-PCR. Sera from 1,200 were analysed for IAV antibodies ELISA haemagglutination inhibition (HI). Avian virus (AIV) was detected 0.2% (n = 5) but not farmers. Virus detection more pronounced cloacal 4, 0.3%) than tracheal 1, 0.1%). AIV chickens. Two (2.0%) tested positive to human...
This case study is based on an outbreak investigation conducted by multisectoral team from animal and public health offices in Kaktong (a remote village Zhemgang District Bhutan) during July-September 2010. caused ingestion of infected cow meat which had died after a brief illness (bleeding unclotted blood nostrils). The owner the affected opened carcass dressed meat, he shared or sold within for human consumption. It simulates epidemiological including active passive finding, descriptive...
Introduction: Tumor necrosis factor α-inhibitors (TNF-α-inhibitors) are biological disease-modifying anti-rheumatic drugs (bDMARD’s) that used in the treatment of different immune mediated inflammatory diseases (IMIDs) (eg. rheumatoid arthritis, psoriasis, Crohn’s disease…). TNF-inhibitors generally well tolerated and safe, but some major challenges remain management TNF-inhibitors. 
 First all, only specific specialists (rheumatologist, dermatologist, ophthalmologist,...
Hintergrund: Der Chemokinrezeptor CCR5 ist von großer Bedeutung für die Regulation der Zell-Wanderung. Ein auffälliges Merkmal CCR5-defizienter Mäuse eine robustere T Zell-Antwort. Bei HCV-Infektion wurde „Loss of Function“ Mutation des Rezeptors (CCR5D32) mit einer spontanen Ausheilung assoziiert. Unklar blieb jedoch, über welche Mechanismen Funktion Lymphozyten beeinflusst.
Enteric fever, Dengue and malaria still remain diseases of public health importance in the tropics. The aim study to see serodiagnostic challenges enteric fever cases presenting as co-infection with dengue malaria. cross sectional was conducted department Medicine Department Microbiology, Holy Family Red Crescent Medical College Hospital, from July 2016 June 2017. Febrile patients attending outpatient or admitted hospitals attached Hospital suspected have signs symptoms clinically suggestive...
Vibrio Cholerae is a category B agent which has moderate to high potential be used in bioterrorist events. This fictitious case study based on man-made outbreak investigation and response carried out by disease surveillance unit of country Winland. The numbers acute watery diarrhoea cases (AWDs) were concentrated city Funpur Winland share international border with Robiland, another poor health infrastructure. Regular movement nomadic population between two countries additional risk spread....
This case study was written as part of a fellowship in biosafety and biosecurity organised by the German Biosecurity Programme, namely Global Partnership Initiated Academia for Controlling Health Threats (GIBACHT). Among other objectives, focuses on equipping participants with skills developing their own country-specific studies focus biosafety- biosecurity-related scenarios. Upon completion underlying study, should be able to identify some existing gaps regards early detection investigation...