A5052597480- Inflammasome and immune disorders
- Fatty Acid Research and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Retinoids in leukemia and cellular processes
- Eicosanoids and Hypertension Pharmacology
- GDF15 and Related Biomarkers
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Nutrition and Health in Aging
- IL-33, ST2, and ILC Pathways
- Herpesvirus Infections and Treatments
- Plant Virus Research Studies
- Mast cells and histamine
- RNA regulation and disease
- Synthesis and biological activity
- Regulation of Appetite and Obesity
- Cancer Research and Treatments
- Dermatology and Skin Diseases
Inserm
2017-2024
Université de Lille
2017-2024
Institut Pasteur de Lille
2016-2024
Centre Hospitalier Universitaire de Lille
2017-2024
University of Liège
2012-2020
Institut de Virologie
2017
The NLRP3 inflammasome is involved in many obesity-associated diseases, such as type 2 diabetes, atherosclerosis, and gouty arthritis, through its ability to induce interleukin (IL)-1β release. molecular link between obesity activation still unclear, but free fatty acids have been proposed one triggering event. Here we reported opposite effects of saturated (SFAs) compared with unsaturated (UFAs) on human monocytes/macrophages. Palmitate stearate, both SFAs, triggered IL-1β secretion a...
Plasma growth differentiation factor-15 (GDF-15) levels increase with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) but the underlying mechanism remains poorly defined. Using male mouse models of MASLD, biopsies from carefully-characterized patients regarding obesity, type 2 diabetes (T2D) MASLD status, we identify adipose tissue (AT) as key source GDF-15 at onset T2D, followed by during progression towards steatohepatitis (MASH). Obesity T2D GDF15 expression...
Endothelial cells (ECs) are highly plastic, capable of differentiating into various cell types. Endothelial-to-mesenchymal transition (EndMT) is crucial during embryonic development and contributes substantially to vascular dysfunction in many cardiovascular diseases (CVDs). While targeting EndMT holds therapeutic promise, understanding its mechanisms modulating pathways remain challenging. Using single-cell RNA sequencing on three vitro models, we identified conserved gene signatures. We...
The cell wall of mycobacteria is characterised by glycolipids composed different classes mycolic acids (MAs; alpha-, keto-, and methoxy-) sugars (trehalose, glucose, arabinose). Studies using mutant <i>Mtb</i> strains have shown that the structure MAs influences inflammatory potential these glycolipids. As <i>Mtb </i>strains possess a complex mixture glycolipids, we analysed single mycolate esters 38 synthetic analogues. Our results show trehalose dimycolate (TDM)...
Growth differentiation factor-15 (GDF-15) and its receptor GFRAL are both involved in the development of obesity insulin resistance. Plasmatic GDF-15 level increases with is positively associated disease progression. Despite macrophages have been recently suggested as a key source obesity, little known about regulation these cells. In present work, we sought for potential pathophysiological activators GDF15 expression human identified saturated fatty acids (SFAs) strong inducers secretion....
In obesity, adipose tissue infiltrating macrophages acquire a unique pro-inflammatory polarization, thereby playing key role in the development of chronic inflammation and Type 2 diabetes. Increased saturated fatty acids (SFAs) levels have been proposed to drive this specific polarization. Accordingly, we investigated immunometabolic reprogramming SFA-treated human macrophages. As expected, RNA sequencing highlighted profile but also metabolic signatures including glycolysis hypoxia as well...
Hepatitis C virus (HCV) infection causes 500,000 deaths annually, in association with end-stage liver diseases. Investigations of the HCV life cycle have widened knowledge virology, and here we discovered that two piperazinylbenzenesulfonamides inhibit entry into cells. The host cells is a complex process not fully understood but characterized by multiple spatially temporally regulated steps involving several known factors. Through high-content screening analysis library 1,120 biologically...
The protein encoded by ORF9 is essential for varicella-zoster virus (VZV) replication. Previous studies documented its presence in the trans-Golgi network and involvement secondary envelopment. In this work, we deleted ORF9p acidic cluster, destroying interaction with ORF47p, resulted a nuclear accumulation of both proteins. This phenotype results an primary enveloped capsids perinuclear space, reflecting capsid de-envelopment defect.
Abstract Retinoic acid receptor-related orphan receptor-alpha (RORα) is a transcription factor from the nuclear receptor family expressed by immune cells and involved in development of obesity, insulin resistance (IR) non-alcoholic steatohepatitis (NASH). It was recently reported that mice deficient for RORα macrophages develop more severe NASH upon high fat diet (HFD) feeding due to altered Kupffer cell function. To better understand role obesity IR, we independently generated macrophage...
The nuclear receptor superfamily is a potential target for the development of new treatments obesity and metabolic diseases. Increasing evidence has pointed towards retinoic acid-related orphan receptor-alpha (RORα) as an important involved in several biological processes. RORα full body knockout mice display improved phenotypes on both chow high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here we investigated effect hepatic by generating with...