A5045143021- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Diseases and Immunity
- Healthcare Systems and Reforms
- Proteoglycans and glycosaminoglycans research
- Curcumin's Biomedical Applications
- Wound Healing and Treatments
- Coconut Research and Applications
- COVID-19 and healthcare impacts
- Vitamin C and Antioxidants Research
- Laser Applications in Dentistry and Medicine
- Healthcare cost, quality, practices
- Hernia repair and management
- Surgical Sutures and Adhesives
- Hepatitis C virus research
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Whipple's Disease and Interleukins
- Tendon Structure and Treatment
- Tuberculosis Research and Epidemiology
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Pregnancy and Medication Impact
- Muscle and Compartmental Disorders
Universidade Federal do Rio Grande do Norte
2015-2023
Hospital Universitário Onofre Lopes
2015-2023
Ulcerative colitis (UC) and Crohn's disease (CD) are inflammatory bowel diseases (IBDs) with multifactorial causes. They becoming more prevalent in developing countries such as Brazil; however, relevant studies poorer regions of the country limited. Here, we report clinical-epidemiological profile patients IBD treated at reference centers three states Northeast Brazil.This was a prospective cohort study involving referral outpatient clinics for from January 2020 through December 2021.Of 571...
Purpose: To examine the effects of a negatively charged nanostructured curcumin microemulsion in experimental ulcerative colitis (UC) rats. Methods: Four percent acetic acid was used to induce UC. The animals were treated for seven days and randomly assigned four groups: normal control (NC), colitis/normal saline (COL/NS), colitis/curcumin (COL/CUR), colitis/mesalazine (COL/MES). formulated with negative zeta potential (-16.70 ± 1.66 mV). Dosage pro-inflammatory cytokines tumor necrosis...
PURPOSE: Hepatocellular carcinoma (HCC) is a frequent and fatal human cancer with poor diagnosis that accounts for over half million deaths each year worldwide. Curcumin has wide range of pharmacological activities. This study aimed to investigate the chemopreventive therapeutical effect against diethylnitrosamine (DEN)-induced HCC in rats. METHODS: was induced rats by single injection DEN (50 mg/kg) once week, i.p., four weeks. Group 1 were orally treated curcumin two weeks prior continued...
Inflammatory bowel disease (IBD) is a of increasing prevalence in developing countries. Obesity has emerged as potential risk for IBD; however, the data literature are conflicting, and relevant studies Brazil limited. Here, we report body mass index profile (BMI) patients with IBD treated at reference centers three states northeastern Brazil.Observational descriptive study conducted from January 2021 through December patient IBD.Of 470 IBD, 194 (41%) were classified normal weight, 42 (9%)...
Purpose: The objective of this study was to evaluate the efficacy peritoneal lavage with coconut water in healing colonic anastomoses a model abdominal sepsis rats. Methods: Twelve Wistar rats were used. animals randomly selected and distributed 2 groups, six each. Group 1: + 0.9% saline solution 2: water. Induction performed through exteriorization cecum ligature. After ligation, 4 perforations gentle pressure made cecum, allowing small amount stool escape. then replaced cavity incision...
Purpose: The objective of this study was to examine the effect topical hyaluronic acid (HA) treatment on wound healing in rats. Methods: Wistar rats were randomly selected and allocated into 2 groups, with six each, all them submitted skin lesions (open 5mm diameter). Group 1 – treated 0,9% saline application wounds. 0,4% wounds once a day for 7 days. After anesthesia 7th postoperative day, biopsy dorsal area performed histopathological examination. A classification system based degree...
Purpose: This study aims to analyze the effects of peritoneal lavage with coconut water on reaction in abdominal sepsis model rats. Methods: We used 12 male Wistar rats weighing between 310±15 g. The animals were randomly distributed into 2 groups, 6 each. Abdominal was induced by cecum ligation and puncture (CLP) both groups. Group 1 subjected three times 5 ml saline each time; submitted 5ml also times. Peritoneal occurred 24 hours after CLP. Twenty four after, liquid from cavity harvested...
Purpose: This study was designed to investigate the pharmacological efficacy of simvastatin against ureteral mucositis cyclophosphamide-induced. Methods: Wistar rats weighing 287±14g were used. A single dose cyclophosphamide (CYP) 200mg/kg IP + oral (10mg/kg) administered in (CYP/SIMV) group (n=6), In (CYP/SAL) saline v.o. administered. The animals weighed daily. After 7 days CYP administration, blood collected by cardiac puncture under anesthesia. euthanasia, uterers for histopathology....
Objective: The potential antitumor effects of the levamisole immunomodulatory agent remain uncertain, and its beneficial with increased survival in adjuvant treatment malignant tumors are controversial. present study aims to compare cisplatin urethane-induced lung carcinoma rats. Methods: Wistar rats were allocated into three groups (n = six each). Group A: mice tumor + levamisole. B: treatment. C: saline After 12 weeks induction process, results validated by ex vivo fluorescence imaging,...
Abstract Background Anti-TNF therapy represented a landmark in medical treatment of ulcerative colitis (UC). There is lack data on the efficacy and safety these agents Brazilian patients. The present study aimed to analyze rates clinical endoscopic remission comparatively, between adalimumab (ADA) infliximab (IFX), patients with UC, evaluate factors associated after 1 year treatment. Methods A national retrospective multicenter (24 centers) was performed including UC treated anti-TNF...
The diagnosis of liver cirrhosis in patients with chronic hepatitis C has not always been easy, since the gold standard method is biopsy, which an invasive procedure interobserver accuracy problems and there have reports complications including records deaths due to hemoperitoneum. Cirrhosis changes prognosis subject requires a different clinical management. This study aimed identify laboratory variables associated ultrasonography infected C. In case-control study, we evaluated 70 cirrhotic...
Abstract Background There are few data on the quality-of-care for inflammatory bowel disease (IBD) in public, private or mixed hospitals, especially Latin America. The aim of study was to evaluated clinic and quality parameters their association with need ICU death Brazilian hospitals. Methods This a multicentre carried out 26 Four hundred eighty-eight admissions patients IBD were analysed between June 2021 October 2022. Results median stay length 6 days (0–121). age 38 years (16–87), 265...
Background: There are few data on the quality-of-care for inflammatory bowel disease (IBD) in public, private or mixed hospitals. Aim: To evaluated clinic and quality parameters their association with need ICU death Brazilian Methods: Multicentre study carried out 26 hospitals including 488 admissions of patients IBD were analyzed between June 2021 October 2022. Results: The median stay length was 6 days (0–121). age 38 years (16–87), 265 (54.6%) female; 339 (69.5%) had Crohn’s (CD) 149...
Purpose: To compare two techniques of suture on the stomach wall. Single-layer and two-layer gastric were compared, evaluating: evolution epithelialization process in mucosa; tensile strength histopathological changes area. Methods: Twelve (12) Wistar rats weighing 220 ± 18g used. Group 1 (n = 6) – Gastric incision was sutured with single interrupted sutures extramucosal single-layer; group 2 had technique. 6-0 polypropylene thread atraumatic needle On seventh postoperative day animals...
Purpose: The objective of this study was to examine the effect topical hyaluronic acid (HA) treatment on wound healing in diabetic rats. Methods: Wistar rats weighing 279 ± 32g were randomly selected and allocated into 2 groups, with six each, all submitted diabetes induction streptozotocin. Under anesthesia, a 1 cm2 open made back skin animals. Group - treated 0.9% saline use wounds. 0.4% HA over lesions. After anesthesia 10th postoperative day, biopsy dorsal area, including entire wound,...
Introduction: Intra-abdominal sepsis is one of the most difficult situations in surgery and usually presents as a peritonitis. It systemic inflammatory response to infection that often associated with hypoperfusion followed by tissue injury organ failure. Given its sequelae reflect increasing severity infection, correct early treatment needs be established. In this sense, study analyzes effect peritoneal lavage use isomers immunomodulator abdominal rats. Methods: The animals were randomly...