A5039153659- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Pharmacology and Obesity Treatment
- Pharmaceutical Practices and Patient Outcomes
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Cancer Diagnosis and Treatment
- Dermatological and Skeletal Disorders
- Chronic Disease Management Strategies
- Medical Imaging and Pathology Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Management of metastatic bone disease
- Metabolism, Diabetes, and Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Cutaneous Melanoma Detection and Management
- Bone health and treatments
- Cardiac Health and Mental Health
- Diabetes Management and Research
- Biomedical Text Mining and Ontologies
- Childhood Cancer Survivors' Quality of Life
- Multiple and Secondary Primary Cancers
- Amyotrophic Lateral Sclerosis Research
- Foreign Body Medical Cases
- Cancer-related cognitive impairment studies
Mario Negri Institute for Pharmacological Research
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2024
Agenzia Regionale Sanitaria della Puglia
2021-2022
Center for Outcomes Research and Clinical Epidemiology
2019-2021
Mario Negri Sud Foundation
2007-2016
Casa Sollievo della Sofferenza
2012
University of Bari Aldo Moro
2012
The benefit of aspirin for the primary prevention cardiovascular events is relatively small individuals with and without diabetes. This could easily be offset by risk hemorrhage.To determine incidence major gastrointestinal intracranial bleeding episodes in diabetes taking aspirin.A population-based cohort study, using administrative data from 4.1 million citizens 12 local health authorities Puglia, Italy. Individuals new prescriptions low-dose (≤300 mg) were identified during index period...
Studies assessing whether heart failure (HF) is associated with cancer and cancer-related mortality have yielded conflicting results.This study assessed incidence according to pre-existing HF in a community-based cohort.Among individuals ≥50 years of age from the Puglia region Italy administrative health data 2002 2018, no within 3 before baseline evaluation, ≥5-year follow-up, matched 104,020 subjects at control age, sex, drug-derived complexity index, Charlson comorbidity follow-up...
Objectives: Results from basic science and narrative reviews suggest a potential role of β-blockers in patients with sepsis. Although the hypothesis is physiologically appealing, it could be seen as clinically counterintuitive. We sought to assess whether previously prescribed chronic β-blocker therapy had different mortality rate than those who did not receive treatment. Setting: Record linkage administrative databases Italian hospitalized for sepsis during years 2003–2008 were identified...
Objective to develop and validate the Drug Derived Complexity Index (DDCI), a predictive model derived from drug prescriptions able stratify general population according risk of death, unplanned hospital admission, readmission, compare new index with Charlson Comorbidity (CCI). Design Population-based cohort study, using record-linkage analysis prescription databases, discharge records, civil registry. The was developed based on patterns indicative chronic diseases, random sample 50%...
Background Combined treatment (CT) with statins and polyunsaturated fatty acids (n-3 PUFA) resulted in a reduction of death major cardiovascular events when administered after myocardial infarction (MI). However, recent data suggests that CT may be ineffective because patients are currently treated aggressively the risk not further decreased. We aimed to study prevalence results on outcomes among discharged MI Italy. Methodology/Principal findings Retrospective cohort used linked hospital...
Objectives To develop a population-based risk stratification model (COVID-19 Vulnerability Score) for predicting severe/fatal clinical manifestations of SARS-CoV-2 infection, using the multiple source information provided by healthcare utilisation databases Italian National Health Service. Design Retrospective observational cohort study. Setting Population-based study database from five regions. Participants Beneficiaries Service, aged 18–79 years, who had residentship in participating...
Over the years, disease registers have been increasingly considered a source of reliable and valuable population studies. However, validity reliability data from may be limited by missing data, selection bias or quality not adequately evaluated checked. This study reports analysis consistency completeness in Italian Multiple Sclerosis Related Disorders Register.The Register collects, through standardized Web-based Application, unique patients. Data are exported bimonthly to assess updating...
Epidemiological studies reported two contrasting trends: on one hand, a significant improvement in the use of evidence-based treatments patients discharged with myocardial infarction (MI). On other increasing number elderly and co-morbid who are usually less treated. The aim this study is to examine whether improvements treatment MI homogeneously distributed throughout all subgroups patients. Based record linkage administrative registers, 21 423 three different periods (2003, 2005, 2007),...
Cancer in young patients (15-39 years) is unique for the distribution of types, therapeutic options and clinical evolution. Administrative databases represent well-documented tools epidemiology, oncology they are very important those realities without cancer registries. Our study aimed to analyze occurrence, outcomes burden through analysis hospital discharge records.Hospital civil registries were analyzed record linkage technique. Annual incidence rate (AIR), standardized (SR), overall...
Registers collecting data from clinical practice (real world data) have gained increasing interest in recent years the scientific, administrative, and regulatory fields. The value of longitudinal collection deepening knowledge about a specific pathology its healthcare complexity is increasingly recognized. This article describes development, organizational structure, technical characteristics Italian Multiple Sclerosis Related Disorders Register (RISM). multicentre prospective study gathers...
Cancer in young patients (15-39 years) is unique for the distribution of types, therapeutic options and clinical evolution. Administrative databases represent well-documented tools epidemiology, oncology they are very important those realities without cancer registries. Our study aimed to analyze occurrence, outcomes burden through analysis hospital discharge records.Hospital civil registries were analyzed record linkage technique. Annual incidence rate (AIR), standardized (SR), overall...
Abstract Background Studies assessing whether heart failure (HF) is associated with an excess risk of cancer and cancer-related mortality yielded conflicting results. Here, we assessed the incidence according to presence HF in a community-based cohort. Methods By reviewing health care records Puglia region Italy, first selected individuals ≥50-year-old, no history within 3 years before baseline evaluation ≥5 follow-up, during period from January 1st, 2005 December 31st, 2013. Next, matched...