A5050574057- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- T-cell and Retrovirus Studies
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- IL-33, ST2, and ILC Pathways
- Neutropenia and Cancer Infections
- Immune cells in cancer
- CAR-T cell therapy research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antifungal resistance and susceptibility
- Blood disorders and treatments
- Vector-Borne Animal Diseases
- Single-cell and spatial transcriptomics
- Tryptophan and brain disorders
- Silkworms and Sericulture Research
- Gastrointestinal Tumor Research and Treatment
- Multiple Myeloma Research and Treatments
Tohoku University
2020-2024
Tohoku University Hospital
2019-2024
Tokyo National Hospital
2014-2019
Hudson Institute
2019
John Wiley & Sons (United States)
2019
Abstract Memory-phenotype (MP) CD4+ T lymphocytes spontaneously develop in steady state from peripheral naïve precursors a manner dependent on self-antigen recognition. While MP cells possess innate type 1 and 3 effector functions that can contribute to host defense autoimmunity, their immunological tumor immunity graft-versus-host disease (GVHD), which results therapeutic bone marrow transplantation (BMT) against hematological malignancies, remain unclear. Here we show mixed lymphocyte...
Highlights•Invasive fungal disease was common (14%) after steroid therapy for severe graft-versus-host disease•Viral (∼25%) disease•Gram-negative rod infection (20%) disease•Graft-versus-host within 26 days and low lymphocyte count correlated with risk of infection•Cumulative doses risks viral diseasesAbstractThis study aimed to characterize the incidence factors invasive disease, cytomegalovirus infection, other diseases, gram-negative glucocorticoid treatment acute (GVHD) allogeneic...
Abstract CD4 + T lymphocytes consist of naïve, antigen-specific memory, and memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like effector function during host defense, but whether are functionally heterogeneous and, if so, what signals specify the differentiation subpopulations under homeostatic conditions is still unclear. Here we characterize as consisting T-bet high , low − subsets, with innate, Th1-like activity exclusively associated...
Double-expressor lymphoma (DEL) is a diffuse large B cell that exhibits co-expression of MYC and BCL2 proteins by immunohistochemistry. Patients with double-expressor have poor prognosis after standard chemoimmunotherapy or high-dose chemotherapy autologous transplantation, but the prognostic impact DEL allogeneic hematopoietic transplantation has not been well characterized. We retrospectively analyzed 60 consecutive patients de novo transformed follicular who underwent at our center had...
Under steady-state conditions, conventional CD4+ T lymphocytes are classically divided into naïve (CD44lo CD62Lhi) and memory (CD44hi CD62Llo) cell compartments. While the latter population is presumed to comprise a mixture of distinct subpopulations explicit foreign antigen (Ag)-specific "authentic" Ag-independent memory-phenotype (MP) cells, phenotypic markers differentially expressed in these two types have yet be identified. Moreover, while MP cells themselves been previously described...
Conventional CD4 + T lymphocytes consist of naïve, foreign antigen-specific memory, and self-antigen-driven memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells tonically proliferate in response to self-antigens differentiate into the T-bet subset steady state. How excess proliferation differentiation are inhibited remains unclear. Given immunosuppressive function regulatory (Tregs), it is possible they also involved inhibition spontaneous activation. Here...
A 21-year-old man was diagnosed with myeloid/natural killer precursor leukemia (MNKPL) bone marrow infiltration of blasts cyCD3
Nodal Epstein-Barr virus-positive T/NK-cell lymphoma (EB-nTNKL) is an extremely rare disease characterized by aggressive clinical course and poor prognosis, for which treatment strategies have not yet been established. We herein report a young man with EB-nTNKL. Although initial chemotherapies, including L-asparaginase, failed to produce good response, subsequent myeloablative allogeneic hematopoietic stem cell transplantation (alloHSCT) resulted in favorable control long-term disease-free...
Impact of the double expression MYC and BCL2 on outcomes localized primary gastric diffuse large B-cell lymphoma patients in rituximab era
Abstract Objective CD204 + tumor‐associated macrophages are associated with adverse outcomes of various malignancies. We performed a study to elucidate the role in allogeneic hematopoietic cell transplantation (allogeneic HCT). Methods In total 81 patients who received HCT for non‐remission malignant lymphoma, immunohistochemical staining using specimens preserved before was performed. According average number high‐power field, were categorized into three groups: low (<25th percentile),...
<title>Abstract</title> Although rearrangement of the MYC oncogene (MYC-R) is frequently observed in aggressive B-cell lymphomas, it extremely rare T-cell malignancies. A 64-year-old man who had been under observation for several years because asymptomatic pulmonary extranodal marginal zone lymphoma mucosa-associated lymphoid tissue(MALToma) was admitted to our hospital poor general condition and hypotension. Blood tests revealed thrombocytopenia elevated serum lactate dehydrogenase levels,...
Abstract Foxp3- CD4+ T lymphocytes consist of naïve (CD44lo), foreign antigen-specific memory, and self antigen-driven memory-phenotype (MP; both CD44hi) cells at homeostasis. We recently showed that self-reactive MP spontaneously proliferate differentiate into the T-bet+ subset. How excess proliferation Th1 differentiation are inhibited in steady state remains unclear. Regulatory (Tregs) can inhibit several immune responses, posing a possibility same may suppress spontaneous cell...
Memory-phenotype (MP) CD4 + T lymphocytes develop from naïve cells via self-recognition at homeostasis. While previous studies defined MP as a heterogeneous population that comprises helper 1 (T H 1)/17–like subsets, functional significance of the T-bet − Rorγt subpopulation remains unknown. Here we show whole can differentiate into 1/17/regulatory reg ) to mediate mild and persistent inflammation in lymphopenic environments, whereas exhibit strong, 1-dominated responses. Moreover,...
Background: Platinum derivatives play important roles in salvage chemotherapy of malignant lymphoma, but may cause renal dysfunction. We examined the influence pretransplant platinum-based on function and outcomes after allogeneic hematopoietic cell transplantation (HCT) for lymphoma. Methods: This retrospective study cohort included 229 adult patients with lymphoma who had a first HCT between 2000 2014 at our center. collected cumulative doses cisplatin (CDDP) carboplatin (CBDCA) before...