A5068184462- Marine Biology and Environmental Chemistry
- Vector-borne infectious diseases
- Echinoderm biology and ecology
- Mass Spectrometry Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Meat and Animal Product Quality
- Salivary Gland Disorders and Functions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Adipose Tissue and Metabolism
- Trace Elements in Health
- Environmental Toxicology and Ecotoxicology
- Antimicrobial Peptides and Activities
- Muscle metabolism and nutrition
- Crystallization and Solubility Studies
- Photosynthetic Processes and Mechanisms
- Enzyme-mediated dye degradation
- Advanced Glycation End Products research
- Alzheimer's disease research and treatments
- X-ray Diffraction in Crystallography
- Fermentation and Sensory Analysis
- Metabolomics and Mass Spectrometry Studies
- Horticultural and Viticultural Research
- Microbial Metabolism and Applications
- Marine Ecology and Invasive Species
- Protein Hydrolysis and Bioactive Peptides
Instituto de Tecnología Química
2004-2024
Instituto de Biologia Experimental e Tecnológica
2010-2024
Universidade Nova de Lisboa
2015-2024
University of Lisbon
1993-2024
Energias de Portugal (Portugal)
2023
University of Trás-os-Montes and Alto Douro
2023
Hospital do Desterro
2022
Centro Hospitalar do Porto
2022
Karolinska Institutet
2022
Instituto Português Da Qualidade
2006-2020
Protein modification has entered the limelight of chemical and biological sciences, since, by appending small molecules into proteins surfaces, fundamental biophysical processes may be studied even modulated in a physiological context. Herein we present new strategy to modify lysine's ε-amino group protein's N-terminal, based on formation stable iminoboronates aqueous media. This functionality enables complete these amine groups, which can reversible upon addition fructose, dopamine, or...
Extracts of leaves, fruits and seeds olive tree cultivars Trás-os-Montes e Alto Douro (Portugal) were analysed by reverse phase HPLC with diode array detection mass spectrometry (MS). This methodology allowed the identification some common phenolic compounds, namely, verbascoside, rutin, luteolin-7-glucoside, oleuropein hydroxytyrosol. Moreover hyphenation MS enabled nüzhenide in seeds. An glucoside was also detected leaves. The total content determined Folin Denis reagent antioxidant...
Abstract Background Insulin is a hormone that regulates blood glucose homeostasis and central protein in medical condition termed insulin injection amyloidosis. It intimately associated with glycaemia vulnerable to glycation by other highly reactive carbonyls like methylglyoxal, especially diabetic conditions. Protein involved structure stability changes impair functionality, several human diseases, such as diabetes neurodegenerative diseases Alzheimer's disease, Parkinson's disease Familiar...
All bryophytes evolved desiccation tolerance (DT) mechanisms during the invasion of terrestrial habitats by early land plants. Are these DT still present in that colonize aquatic habitats? The bryophyte Fontinalis antipyretica Hedw. was subjected to two drying regimes and alterations protein profiles sucrose accumulation dehydration rehydration were investigated. Results show fast dehydration, there is very little variation profiles, upon proteins are leaked. On other hand, slow induces...
Colostrum intake by newborn lambs plays a fundamental role in the perinatal period, ensuring lamb survival. In this study, blood plasma samples from two groups of (Colostrum group and Delayed group) at 2 14 h after birth were treated to reduce content high abundance proteins analyzed using Two-Dimensional Differential Gel Electrophoresis MALDI MS/MS for protein identification order investigate low with immune function lambs. The results showed that four increased due colostrum intake. These...
Protein glycation by methylglyoxal is a nonenzymatic post-translational modification whereby arginine and lysine side chains form chemically heterogeneous group of advanced end-products. Methylglyoxal-derived end-products are involved in pathologies such as diabetes neurodegenerative diseases the amyloid type. As produced nonenzymatically from dihydroxyacetone phosphate d-glyceraldehyde 3-phosphate during glycolysis, its formation occurs all living cells. Understanding model systems will...
Potential biological markers for cystic fibrosis (CF) lung disease were identified by comparative proteomics profiling of nasal cells from deletion phenylalanine residue 508 (F508del)-homozygous CF patients and non-CF controls. From the 2-DE gels, 65 spots MS, a reference map was thus established. The majority those correspond to ubiquitously expressed proteins. Consistent with epithelial origin this tissue, some proteins are (e.g. cytokeratins, palate epithelium clone protein (PLUNC),...