A5005451978- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Intramuscular injections and effects
- Blood groups and transfusion
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Renal cell carcinoma treatment
- Central Venous Catheters and Hemodialysis
- Parvovirus B19 Infection Studies
- Hemoglobinopathies and Related Disorders
- Genomics and Rare Diseases
- Protein Kinase Regulation and GTPase Signaling
Thomas Jefferson University Hospital
2019-2021
Thomas Jefferson University
2020
University of Pennsylvania
2014-2017
Cleveland Clinic
2012-2016
Penn Center for AIDS Research
2014-2016
Cancer Institute (WIA)
2015
Mutational inactivation in cancer of key apoptotic pathway components, such as TP53/p53, undermines cytotoxic therapies that aim to increase apoptosis. Accordingly, TP53 mutations are reproducibly associated with poor treatment outcomes. Moreover, treatments destroy normal stem cells intact p53 systems, a problem especially for myeloid neoplasms, these reverse the low blood counts cause morbidity and death. Preclinical studies suggest noncytotoxic concentrations DNA methyltransferase 1...
The Na+-HCO3- cotransporter NBC1 is located exclusively on the basolateral membrane and mediates vectorial transport of bicarbonate in a number epithelia, including kidney pancreas. To identify motifs that direct targeting to membrane, wild type various carboxyl-terminally truncated mutants were generated, fused translationally in-frame GFP, transiently expressed epithelial cells. GFP was linked NH2 terminus NBC1, labeling examined by confocal microscopy. Full-length (1035 aa) with deletion...
Introduction Cerebral microbleeds ( CMB s) represent clinically silent haemorrhagic events. portend negative neurovascular and cognitive outcomes in the general population are associated with impairment persons haemophilia PWH ). Prevalence, patterns, risk factors for s have not been directly compared to without coagulopathy. Aim To examine prevalence, vs normal controls. Methods Adults A or B haemostatically controls were recruited. Subjects excluded if taking an antithrombotic agent other...
The clinical diagnosis of qualitative platelet disorders (QPDs) based on light transmission aggregometry (LTA) requires significant blood volume, time, and expertise, all which can be barriers to utilization in some populations settings. Our objective was develop a more rapid assay function by measuring platelet-mediated clot contraction small volumes (35 µL) whole using T2 magnetic resonance (T2MR).We established normal ranges for T2MR, used these study patients with known dysfunction, then...
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