A5012924512- Chemokine receptors and signaling
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Microtubule and mitosis dynamics
- Metabolism and Genetic Disorders
- Vascular Malformations Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Selenium in Biological Systems
- Cancer Treatment and Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- Trace Elements in Health
- Advanced Nanomaterials in Catalysis
- Cancer, Hypoxia, and Metabolism
- Multiple Myeloma Research and Treatments
- Synthesis and Biological Evaluation
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Nanocluster Synthesis and Applications
Tsinghua University
2019-2024
Guangdong Ocean University
2024
Chinese Institute for Brain Research
2023
Center for Life Sciences
2019
Peking University
2014
Abstract Cerebral cavernous malformations (CCMs) and spinal cord (SCCMs) are common vascular abnormalities of the CNS that can lead to seizure, haemorrhage other neurological deficits. Approximately 85% patients present with sporadic (versus congenital) CCMs. Somatic mutations in MAP3K3 PIK3CA were recently reported CCM, yet it remains unknown whether mutation is sufficient induce Here we analysed whole-exome sequencing data for CCM found ∼40% them have a single, specific [c.1323C>G...
Abstract Introduction: CXCR4 is a member of chemokine receptor and G protein coupled (GPCR) families. Its interaction with the chemotactic ligand stromal cell-derived factor 1 (SDF-1 or CXCL12) plays important roles in physiological pathological processes. Recent studies have showed that blockade CXCL12-CXCR4 by small molecules can be used several clinical applications, including sensitizing cancer cells to chemotherapy, mobilizing hematopoietic stem (HSCs) blood for HSC collection,...
Lipid phosphate phosphohydrolase 1 (LPP1), a membrane ectophosphohydrolase regulating the availability of bioactive lipid phosphates, plays important roles in cellular signaling and physiological processes such as angiogenesis endothelial migration. However, regulated expression LPP1 remains largely unknown. Here, we aimed to examine role peroxisome proliferator-activated receptor γ (PPAR ) transcriptional control gene expression. In human umbilical vein cells (HUVECs), quantitative reverse...
Significal challenges exist to bacterial infection wound healing. The and inflammation generated by oxidative stress inevitably hinder the process of Ag6Cu2 nanoclusters in this study were successfully prepared displayed excellent physiological stability. Noticeably, exhibited efficient therapeutic potentials for accelerating healing, which had good biosafety under appropriate concentration. treatment was able suppress proliferation destructing bacterial, resulting secondary release contents...
Acute myeloid leukemia (AML) is a blood cancer characterized by uncontrolled proliferation of leukemic stem/progenitor cells. The retention and chemoresistance AML cells in the bone marrow microenvironment are mediated stromal cell-derived factor-1(SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis. We recently developed novel small molecule CXCR4 antagonist (designated HF51116) with higher affinity than AMD3100 specifically for improving chemotherapy. Competitive binding assays...
Introduction: CXCR4 is a member of chemokine receptor and G protein coupled (GPCR) families. Its interaction with the chemotactic ligand stromal cell-derived factor 1 (SDF-1 or CXCL12) plays important roles in physiological pathological processes. Recent studies have showed that blockade CXCL12-CXCR4 by small molecules can be used several clinical applications, including sensitizing cancer cells to chemotherapy, mobilizing hematopoietic stem (HSCs) blood for HSC collection, inhibiting tumor...