A5104110684- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Kruppel-like factors research
- FOXO transcription factor regulation
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Nitric Oxide and Endothelin Effects
- Retinoids in leukemia and cellular processes
- Glycosylation and Glycoproteins Research
- Wnt/β-catenin signaling in development and cancer
- Photosynthetic Processes and Mechanisms
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- ATP Synthase and ATPases Research
- Congenital heart defects research
University of Chicago
2023-2025
Qingdao University
2025
Westlake University
2023-2024
Shanghai Electric (China)
2024
Sangamo BioSciences (United States)
2024
Lawrence Berkeley National Laboratory
2023
Zhejiang University
2023
Shanghai East Hospital
2023
Joint Genome Institute
2018-2023
Wuxi No.2 People's Hospital
2023
Autocrine vascular endothelial growth factor (VEGF) can regulate the survival and progression of cancers through its various receptors. But mechanisms mediators for these functions are largely uncovered, especially in breast cancer. We examined potential roles VEGF/neuropilin-1 (NRP-1) axis regulating tumorigenesis metastasis cancer found expression VEGF NRP-1 correlated with aggressiveness Knockdown or inhibited proliferation, migration invasion, but enhanced apoptosis MDA-MB-231 cells. In...
Abstract Gene functional descriptions offer a crucial line of evidence for candidate genes underlying trait variation. Conversely, plant responses to environmental cues represent important resources decipher gene function and subsequently provide molecular targets improvement through editing. However, biological roles large proportions across the phylogeny are poorly annotated. Here we describe Joint Genome Institute (JGI) Plant Atlas, an updateable data resource consisting transcript...
Glypican-3 (GPC3) is a heparan sulfate proteoglycan that has an important role in cell growth and differentiation, its function tumorigenesis tissue-dependent. In hepatocellular carcinoma (HCC), the overexpression of GPC3 been demonstrated to be reliable diagnostic indicator. However, mechanisms regulate expression remain unclear. The oncoprotein c-Myc transcription factor plays significant more than 50% human tumors. We report here transcriptional target also regulated by GPC3, thus forming...
Abstract BACKGROUND Hepatoma‐derived growth factor (HDGF) is a novel derived from hepatoma cell line. The current study was designed to elucidate the role of HDGF expression during pathogenesis hepatocellular carcinoma (HCC). METHODS in lines analyzed using reverse transcriptase–polymerase chain reaction (RT‐PCR), Western blot analysis, and immunofluorescence analysis. Immunohistochemical studies were performed examine intensity spatial distribution immunostaining 105 HCC specimens. To...
MicroRNA (miRNA or miR) expression profiles are altered in tissues under hypoxic-ischemic conditions. The of miR‑140 is downregulated >2-fold following brain damage, however, its role angiogenesis subsequent to cerebral ischemia not fully understood. present study aimed investigate the miR-140-5p and molecular mechanism mediated by vascular endothelial growth factor A (VEGFA) an vitro model for ischemia. rat middle artery occlusion (MCAO) was constructed, results from reverse...
Myocardial infarction (MI) compromises the cardiac microvascular endothelial barrier, increasing leakage and inflammation. HIF2α, predominantly expressed in cells during ischemia, has an unclear role barrier function MI. Here, we show that inducible, adult endothelial-specific deletion of Hif2α mice leads to increased mortality, leakage, inflammation, reduced heart function, adverse remodeling after In parallel, human (HCMVECs) lacking HIF2α display impaired integrity, tight-junction...
Long gap esophageal atresia (LGEA) is a rare congenital malformation. Magnamosis represents minimally invasive technique for LGEA to achieve recanalization feeding. Few cases had been reported worldwide. An infant was diagnosed as by using prenatal ultrasound imaging including the absence of gastric bubble and polyhydramnios. confirmed after birth esophagography through gastrostomy esophagus simultaneously. Laparoscopic performed on 3rd day obtain nutrition. The prolonged from proximal...
// San-Cher Chen 1, * , Tsung-Hui Hu 2, Chao-Cheng Huang 3 Mei-Lang Kung 4 Tian-Huei Chu 5 Li-Na Yi 2 Shih-Tsung 6 Hoi-Hung Chan 7 Jiin-Haur Chuang 8 Li-Feng Liu 9 Han-Chung Wu 6, 10 Deng-Chyang 11 Min-Chi Chang 12 Ming-Hong Tai 5, 1 Center for Neuroscience, National Sun Yat-Sen University, Kaohsiung 804, Taiwan Division of Hepato-Gastroenterology, Gung Memorial Hospital-Kaohsiung Medical Center, University College Medicine, 833, Department Pathology, Chemistry, Institute Biomedical...
Abstract Recent genome‐wide association studies (GWAS) have reported multiple genetic variations at 5p15.33 ( TERT‐CLPTM1L ) associated with risk of lung cancer. However, most the identified by GWAS thus far are unlikely to be actual causal variants, but may mostly marker‐single nucleotide polymorphisms tagging functional that influence gene expression. This study aimed explore function‐validated and potentially in locus conferring susceptibility A case–control including 502 cases controls...
Long noncoding RNAs (lncRNAs) are a group of nonprotein coding transcripts that play critical role in cancer progression. However, the lncRNA metformin-induced inhibition cell growth and its biological function gastric remain largely unknown. In this study, we identified an oncogenic lncRNA, Loc100506691, expression which was decreased cells with metformin treatment. Moreover, Loc100506691 significantly overexpressed compared adjacent normal tissues (p < 0.001), high correlated poor survival...
Summary Despite recent progress in the ability to manipulate genomes of eukaryotic cells 1–3 , there is still no effective and practical method precisely integrate large synthetic DNA constructs into desired chromosomal sites using a programmable integrase. Serine integrases can perform necessary molecular steps 4 but only if their natural target site first installed recipient genome by other methods. A more elegant approach would be directly reprogram serine integrase itself endogenous that...
MicroRNAs (miRNAs) function as potential novel biomarkers for disease detection due to their marked stability in the blood and characteristics of expression profile several diseases. In present study, microarray‑based serum miRNA profiling was performed on obtained from three patients with epilepsy at diagnosis healthy individuals controls. This followed by reverse transcription‑quantitative polymerase chain reaction analysis a separate cohort 35 health volunteers 90 epilepsy. The...
MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation tumor suppressors oncogenes during cancer progression. Selection 5p 3p arms miRNA mechanism that improves modulation biological functions complicates regulatory network human types cancer. However, involvement arm selection preference remains unclear. In present study, changes were comprehensively identified corresponding adjacent normal tissues by analyzing The Cancer Genome Atlas. Arm was...
We aimed to investigate the clinical significance of expression novel scaffold protein CARMA3 in non-small-cell lung cancer (NSCLC) and biological function NSCLC cell lines. observed moderate high staining 68.8% 141 specimens compared corresponding normal tissues. The overexpression was significantly correlated with TNM stage (P = 0.022) tumor status 0.013). upregulation also a shorter survival rate patients nodal N0 0.042)as well as epidermal growth factor receptor (EGFR) 0.009). In EGFR...
The prognosis of malignant melanoma is poor due to high incidence metastasis, underscoring the demand for development novel therapeutic strategies. Stress hormone pro-opiomelanocortin (POMC) precursor several anti-inflammatory peptides that hold promise management cancer-related diseases. present study evaluated antimetastatic potential and mechanism POMC therapy metastatic melanoma. Adenovirus-mediated gene delivery potently inhibited invasiveness human mouse cells. Moreover, after...
Abstract Here we report a hydroacid named DWP0016, which exhibited HDAC inhibition and induced p53 acetylation in U251 glioblastoma cells. DWP0016 effectively inhibited the cell growth of cells other four carcinoma lines but did not affect normal Cell cycle distribution analysis showed arrested at G 1 phase dose‐dependently caspase‐dependent independent apoptosis cells, was identified by flow cytometry analysis, caspases activity Western blotting assay, inhibition. Mechanisms research...
Grass biomass is comprised chiefly of secondary walls that surround fiber and xylem cells. A regulatory network interacting transcription factors in part regulates cell wall thickening. We identified Brachypodium distachyon SECONDARY WALL ASSOCIATED MYB1 (SWAM1) as a potential regulator biosynthesis based on gene expression, phylogeny, transgenic plant phenotypes. SWAM1 interacts with cellulose lignin promoters preferential binding to AC-rich sequence motifs commonly found the wall-related...
Currently, there is no effective single antigen and are only a very limited number of complex antigens for the diagnosis early-stage breast cancer (BC). In this study, we used serological analysis recombinant cDNA expression libraries (SEREX) in combination with phage display technology to screen autoantigens from sera BC patients. The library was constructed using tissue samples three patients at as early stage T1N0M0. serum ten patients, including who provided samples, well five healthy...
Malignant melanoma is one of the leading causes cancer mortality worldwide, underlining need for effective novel therapies. In this study, therapeutic efficacy and mechanism systemic pro-opiomelanocortin (POMC) therapy were evaluated in mice bearing established melanoma. Injection adenovirus encoding POMC (Ad-POMC) led to hepatic overexpression elevated adrenocorticotropin (ACTH) levels circulation. Systemic significantly attenuated growth prolonged survival tumor-bearing mice. Histological...