A5055595091- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Long-Term Effects of COVID-19
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Nutritional Studies and Diet
- Sodium Intake and Health
- Galectins and Cancer Biology
- RNA and protein synthesis mechanisms
- Systemic Lupus Erythematosus Research
- Protein Degradation and Inhibitors
- Venous Thromboembolism Diagnosis and Management
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Immune responses and vaccinations
- Genomics, phytochemicals, and oxidative stress
- COVID-19 and healthcare impacts
- Monoclonal and Polyclonal Antibodies Research
- Single-cell and spatial transcriptomics
- Microfluidic and Bio-sensing Technologies
Hebei North University
2025
Tsinghua University
2024-2025
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2022
ORCID
2020-2021
Central Hospital of Wuhan
2020
Zhongnan Hospital of Wuhan University
2020
Huazhong University of Science and Technology
2020
<title>Abstract</title> The Oxidative Balance Score (OBS) serves as a comprehensive metric that amalgamates 17 dietary and lifestyle elements to evaluate antioxidant status. Thi research aims investigate the association between OBS prevalence of chronic kidney disease (CKD) in individuals diagnosed with type 2 diabetes mellitus (T2DM). This cross-sectional study included data from National Health Nutrition Examination Survey (NHANES) conducted 2007 2018. CKD was determined using...
Abstract Antigen‐specific B cells play a crucial role in the long‐term immune response following infection or vaccination, differentiating into antibody‐secreting (ASCs) and memory (MBCs). However, profiling ASCs is challenging primarily due to their lack of membrane‐bound surface cell receptors. In this study, Modular Superhydrophobic Microwell Array Chip (MoSMAR‐chip) introduced as versatile, cost‐effective, high‐throughput platform for identifying characterizing individual...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related mortality worldwide. The oncogenic role Matrin-3 (MATR3), an a nuclear matrix protein, in HCC remains largely unknown. Here, we document biological function MATR3 based on integrated bioinformatics analysis and functional studies. According to TCGA database, expression was found be positively correlated with clinicopathological characteristics HCC. receiver operating characteristic (ROC) curve Kaplan-Meier (KM)...
Leukemia is a group of hematopoietic malignancies characterized by the accumulation and infiltration abnormal stem cells or early progenitor cells. T cell acute lymphoblastic leukemia (T-ALL) hematologic malignancy occurring in 15 % pediatric 25 adult ALL cases. Infiltration metastasis leukemic to specific organs are consequences disease relapse dismal prognosis. Long non-coding RNAs (lncRNAs) have been identified function migration, invasion tumors regulating gene expression. Our previous...
The ongoing evolution and immune escape of SARS-CoV-2, alongside the potential threat SARS-CoV-1 other sarbecoviruses, underscore urgent need for effective strategies against their infection transmission. This study highlights discovery nanobodies from immunized alpacas, which demonstrate exceptionally broad potent neutralizing capabilities recently emerged more divergent SARS-CoV-2 Omicron subvariants including JD.1.1, JN.1, KP.3, KP.3.1.1, as well coronaviruses bats pangolins utilizing...
Abstract Purpose The overexpression of Matrin-3 (MATR3) is associated with tumor progression in several human tumors. However, the role MATR3 hepatocellular carcinoma (HCC) still remains unclear. In this study, we investigated expression HCC and elucidated potential functions cells. Methods differential its association were analyzed using UALCAN database, Human Protein Atlas (HPA) GSE datasets gene profiling interaction analysis2 (GEPIA2) database. Furthermore, performed CCK-8 assays, colony...
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of the lymphoid progenitor cells contributing to ∼ 20% total ALL cases with higher prevalence in adults than children. Despite important role human T-ALL cell lines understanding biology and treatment options, a detailed comparison tumorigenic potential two commonly used lines, MOLT4 JURKAT still lacking. In present study, we compared leukemogenic potentials (MOLT4 JURKAT) NOD-PrkdcscidIL2rgdull...
Abstract Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that the most common cause morbidity and mortality. At present, definitive therapies towards LN remains to be elucidated, so illuminating molecular mechanism behind disease has become an urgent task for researchers. This study set out screen hub genes LN. Methods The microarray expression profile dataset GSE32591 from Gene Expression Omnibus (GEO) database with 15 normal 32 samples was...
Abstract Background： Lung adenocarcinoma (LUAD) is the main histological subtype of lung cancer. However, molecular mechanism underlying LUAD not yet clearly defined, but elucidating this process in detail would be great significance for clinical diagnosis and treatment. Our aim to identify candidate key genes pathways associated with prognosis LUAD. Methods： In study, three gene expression profiles GSE118370, GSE32863 GSE43458 were retrieved from Gene Expression Omnibus database (GEO),...
Purpose: The recognition of new diagnostic and prognostic biological markers for lung cancer is an essential eager study. It’s shown that ion channels play important roles in regulating various cellular processes have been suggested to be associated with patient survival. However, tweety family member 3 (TTYH3), as a maxi-Cl- channel, its role remains elusive.Methods: expression, diagnosis efficacy TTYH3 were analyzed by public databases clinical samples. Cell functional experiments used...
Purpose: The recognition of new diagnostic and prognostic biological markers for lung cancer is an essential eager study. It’s shown that ion channels play important roles in regulating various cellular processes have been suggested to be associated with patient survival. However, tweety family member 3 (TTYH3), as a maxi-Cl- channel, its role remains elusive.Methods: expression, diagnosis efficacy TTYH3 were analyzed by public databases clinical samples. Cell functional experiments used...
Abstract Background: Lung adenocarcinoma (LUAD) is the main histological subtype of lung cancer. However, molecular mechanism underlying LUAD not yet clearly defined, but elucidating this process in detail would be great significance for clinical diagnosis and treatment. Methods: Gene expression profiles were retrieved from Expression Omnibus database (GEO), common differentially expressed genes (DEGs) identified by online GEO2R analysis tool. Subsequently, enrichment function signaling...
Abstract Background Lung adenocarcinoma (LUAD) is the main histological subtype of lung cancer. However, molecular mechanism underlying LUAD not yet clearly defined, but elucidating this process in detail would be great significance for clinical diagnosis and treatment. Methods Gene expression profiles were retrieved from Expression Omnibus database (GEO), common differentially expressed genes (DEGs) identified by online GEO2R analysis tool. Subsequently, enrichment function signaling...