A5041279988- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Cervical Cancer and HPV Research
- Estrogen and related hormone effects
- Angiogenesis and VEGF in Cancer
- Molecular Biology Techniques and Applications
- Urticaria and Related Conditions
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- AI in cancer detection
- Cancer Genomics and Diagnostics
Agostino Gemelli University Polyclinic
2022-2025
Mayo Clinic
2024-2025
WinnMed
2024-2025
Mayo Clinic in Arizona
2024-2025
Università Cattolica del Sacro Cuore
2022-2024
Sapienza University of Rome
2020
This study aimed to evaluate the prevalence of concurrent endometrial cancer in patients pre-operatively diagnosed with atypical hyperplasia undergoing hysterectomy. Additionally, we assessed occurrence high intermediate-risk and high-risk tumors according ESGO-ESTRO-ESP classification. The also compared surgical outcomes complications between simple hysterectomy those sentinel lymph node biopsy. In this multicenter retrospective study, a pre-operative diagnosis were identified divided into...
Alimentary nickel (Ni) may result in allergic contact mucositis (ACM), whose prevalence is >30% and present with IBS-like extra-intestinal symptoms. These symptoms are also frequent endometriosis, Ni dermatitis has already been observed endometriosis. Therefore, intestinal endometriosis depend on a ACM, low-Ni diet could improve We studied the of ACM focused effects gastrointestinal, extra-intestinal, gynecological recruited 84 women symptomatic for gastrointestinal disorders. Thirty-one...
Endometrial cancer (EC) is the most diagnosed gynecologic malignancy, and its incidence mortality are increasing. The prognosis highly dependent on disease spread. Surgical staging includes retroperitoneal evaluation to detect potential lymph node metastases. In recent years, systematic lymphadenectomy has been replaced by sentinel (SLN) biopsy ultrastaging, allowing for detection of macrometastases, micrometastases, isolated tumor cells (ITCs). Micrometastases ITCs have grouped as...
It is unclear whether isolated tumor cells (ITCs) in sentinel lymph nodes (SLNs) adversely affect prognosis, especially low-risk endometrial cancer. In a retrospective study, we showed worse recurrence-free survival for cancer with ITCs than the node-negative group. Our aim to evaluate likelihood of disease recurrence differs between prospective cohort patients and an historical negative SLNs. We hypothesize that will have who are node-negative. This prospective, multi-center, single-arm...
Objective To evaluate the diagnostic performance of one-step nucleic acid amplification (OSNA) method for detection sentinel lymph node (SLN) metastases in women with apparent early-stage endometrial cancer compared standard ultrastaging. Methods Prospective, multicentric, interventional study. Patients who underwent primary surgical staging SLN mapping were included. SLNs serially sectioned 2 mm slices perpendicular to longest axis node: odd submitted ultrastaging, whereas even OSNA...
<h3>Objectives</h3> The goal of this study was to evaluate the depth myometrial invasion as a predictor distant recurrence in patients with node-negative stage IB endometrioid endometrial cancer. <h3>Methods</h3> A retrospective multicenter study, including surgically staged cancer at Mayo Clinic, Rochester (MN, USA) between January 1999 and December 2017, Fondazione Policlinico Universitario A. Gemelli (Rome, Italy) March 2002 conducted. Patients without lymph node assessment were excluded....
Objective Understanding ovarian involvement incidence and risk factors in women with endometrial cancer may inform the decision of ovary preservation. Methods Our retrospective study included all consecutive fully surgically staged patients who underwent primary surgery between January 2005 November 2021, assessing metastasis, its role as a prognostic factor for recurrence death, evaluated predictors adnexal involvement. Results Women International Federation Gynecology Obstetrics (FIGO)...
<h3>Introduction/Background</h3> Transvaginal ultrasound (TVUS) is a method used to triage patients experiencing postmenopausal bleeding (PMB). TVUS detects endometrial atypical hyperplasia (EAH) and cancer (EC). We aimed develop evaluate an Artificial Intelligence (AI) pipeline on images of PMB automatically segment classify them as EAH/EC or benign. <h3>Methodology</h3> Our study included 480 with who underwent biopsy at Mayo Clinic (01/2016–09/2023). For each patient, two static were...
<h3>Introduction/Background</h3> The new molecular classification of endometrial cancer (EC) has been shown to improve prognosis prediction and it recently incorporated in the 2023 FIGO staging. However, exact risk type metastases at time diagnosis their prognostic value each subgroup are currently unknown. <h3>Methodology</h3> EUGENIE is an ongoing prospective multicentre study, aiming traditional surgery-based staging by use classification. 1000 EC patients will receive a complete surgical...
Objectives: Sentinel lymph node biopsy is considered a crucial step in endometrial cancer staging. Cervical injection has become the most favored technique and indocyanine green been demonstrated to be more accurate than other tracers. Different near-infrared camera systems are currently being used detect sentinel nodes have compared different patients. The present study aimed determine number site of detected same patients with two technologies. Methods: This prospective, single-center,...
<h3>Introduction/Background</h3> The molecular classification of endometrial cancer (EC) has been shown to surpass histological subtyping and grading more efficiently predict prognosis. However, not affected our surgical approach only a few studies investigated the relationship between four subgroups tumor spread beyond uterus. We aim improve current risk system by integrating disease stage into classification. <h3>Methodology</h3> EUGENIE is prospective multicentre study aiming include 1000...
<h3>Introduction/Background</h3> Mismatch repair deficiency (MMRd) accounts for 20–30% of all endometrial cancers (EC). MMRd ECs are characterized by the loss at least one MMR proteins (MLH1/PMS2/MSH2/MSH6) immunohistochemistry (IHC), with MLH1-PMS2 and MSH2-MSH6 occurring mostly as heterodimers. The group has been associated a good-intermediate prognosis. However, value different patterns not explored. We aim characterizing how protein expression clinicopathological data....
<h3>Introduction/Background</h3> Approximately 40% of complex atypical hyperplasia (CAH) are finally upstaged to invasive endometrial carcinoma (EC).The aim this study was identify pre-operative variables that can predict the presence concomitant EC at final histopathological analysis, so as a population increased risk and help clinician in preoperative surgical management patients with CAH. <h3>Methodology</h3> Multicenter-retrospective analysis diagnosis CAH who underwent total...
<h3>Introduction/Background</h3> The role of sentinel lymph node mapping in patients with complex atypical hyperplasia (CAH) is a debated topic literature and needs to be clarified.The aim this study was describe the surgical outcomes, intra-postoperative complications CAH undergoing radical staging or without sentinel-lymph-node (SLN) biopsy, incidence histopathological features endometrial cancer (EC) diagnosed each group. <h3>Methodology</h3> All pre-operative diagnosis were...
<h3>Introduction/Background</h3> To assess the incidence of endometrial cancer (EC) FIGO stage IIIA, and evaluate predictors adnexal involvement, its role as prognostic factor recurrence death in EC. <h3>Methodology</h3> Records all consecutive EC patients who underwent primary surgery between January 2005 November 2021 at Fondazione Policlinico A. Gemelli, Rome, were retrospectively reviewed. Potential predictive factors involvement assessed by logistic regression models. Overall survival...