A5050844950- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Acupuncture Treatment Research Studies
- Endometriosis Research and Treatment
- Ferroptosis and cancer prognosis
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Nutrition and Health in Aging
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Gut microbiota and health
- Apelin-related biomedical research
- GDF15 and Related Biomarkers
- Intensive Care Unit Cognitive Disorders
- Biochemical Acid Research Studies
- Muscle Physiology and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Healthcare and Venom Research
- Reproductive Physiology in Livestock
- Oral health in cancer treatment
- Dietary Effects on Health
- Biomedical Ethics and Regulation
- Metabolism, Diabetes, and Cancer
- Reproductive Health and Technologies
Shuguang Hospital
2022-2025
Shanghai University of Traditional Chinese Medicine
2022-2025
Hunan Academy of Traditional Chinese Medicine
2024
Shanghai Jiao Tong University
2020-2022
Shanghai First People's Hospital
2020-2022
Human amniotic fluid stem cell-derived exosome (HuAFSC-exosome) transplantation is considered a promising treatment for premature ovarian failure (POF). However, its mechanism remains unclear. In this study, exosomes were isolated and enriched from HuAFSC subsets of CD44+/CD105+, the transplanted into POF model in vitro vivo. Our results confirmed that produced by CD44+/CD105+ HuAFSCs could achieve therapeutic effects mouse model. research also showed HuAFSC-exosomes carrying miR-369-3p...
Renal cell carcinoma (RCC) is the most common type of primary renal parenchymal malignancy in adults, with a high degree and poor prognosis.Human cancer stem cells (HuRCSCs) are reported to be main cause drug resistance, metastasis, recurrence, prognosis.Erianin low molecular-weight bibenzyl natural product extracted from Dendrobium chrysotoxum, which inhibits vitro vivo activity variety cells.However, molecular mechanisms Erianin's therapeutic effect on HuRCSCs unknown.Here, we isolated...
The morbidity and mortality rates associated with non-small-cell lung carcinoma (NSCLC) are increasing every year, placing new demands on existing therapies drugs. Ammonium ferric citrate (AFC) is often used as a food additive for iron supplementation; however, to our knowledge, no studies have investigated whether AFC can induce ferroptosis in NSCLC. In this study, we demonstrated that specific concentrations of effectively inhibit the proliferation invasion cancer cell lines vitro using...
Context: As a flavonoid compound, kaempferol has great potential in anti-lung cancer therapy, but the mechanism of its therapeutic effect needs further exploration.Objective: To explore on lung cancer, as well capability to regulate gut microbiota and stimulate immune function.Materials & methods: Twenty-four BALB/c mice were divided into four groups.The first two groups, consisting 12 normal mice, administered either PBS or Kaempferol (Kaem) via gavage.The remaining which subcutaneously...
Abstract Objective Thymopentin (5TP) significantly improved typical murine premature ovarian failure (POF) symptoms induced by a high‐fat and high‐sugar (HFHS) diet. However, its effect mechanism remain unclear. Materials methods RNA‐Seq was used to detect the differentially expressed genes among each group. HFHS‐induced POF mouse model generated injected with siRNA using Poly (lactic‐co‐glycolic acid) (PLGA) as carrier. Results suggested that 5TP promoted expression of Yin Yang 2 (YY2) in...
Premature ovarian failure (POF) is the leading cause of female infertility, and there no optimal treatment or medication available currently. For POF, electroacupuncture (EA) has been considered a promising therapeutic approach, but mechanism for this not clear. In study, we explored effects EA (CV4, ST36, SP6) on oxidative stress intestinal microbiota high-fat high-sugar- (HFHS-) induced POF mice. The development mice follicles was observed by hematoxylin eosin (HE) staining. serum levels...
Gastric cancer is a highly malignant tumor. stem cells (GCSCs) are the main causes of drug resistance, metastasis, recurrence, and poor prognosis. As secondary metabolite lichen, Atranorin has variety biological effects, such as antibacterial, anti-inflammatory, analgesic, wound healing; however, its killing effect on GCSCs not been reported. In this study, we constructed complexes comprising superparamagnetic iron oxide nanoparticles (SPION) (Atranorin@SPION). vitro in vivo experiments...
Premature ovarian failure (POF) is a typical form of pathological aging with complex pathogenesis and no effective treatment.Meanwhile, recent studies have reported that high-fat high-sugar (HFHS) diet adversely affects function ovum quality.Here, we investigated the therapeutic effect thymopentin (TP-5) as treatment for murine POF derived from HFHS its target.Pathological examination hormone assays confirmed TP-5 significantly improved symptoms.And, could reduce oxidative stress injury...
Preeclampsia, a multisystem disorder of unknown etiology, is one the leading causes maternal and perinatal morbidity mortality. Identifying sensitive, noninvasive markers can aid its prevention improve prognosis. microRNAs (miRs), which function as negative regulators gene expression, are closely related to preeclampsia occurrence development. Herein we investigated relationship between DLK1-Dio3 imprinted miR cluster derived from placental peripheral blood exosomes pregnant women with...
Premature ovarian failure (POF) is a type of pathological aging, which seriously interferes with the fertility affected women. Electroacupuncture (EA) may have beneficial effect; however, its mechanism action unknown. The purpose this study was to determine effect EA on function in granulosa cells (OGCs) cyclophosphamide (CTX)-induced mouse model POF.Mice were divided into three groups: wild (WT) group, CTX group and + group. administered under isoflurane anesthesia at CV4, ST36 SP6 for 30...
Chinese herbal medicines are effective for treating colon cancer (CC). CC development is reportedly associated with gut microbiota dysbiosis and immune function dysregulation. Herein we explored the therapeutic effects of a medicine anticancer cocktail soup (CHMACS) on mice also its regulatory microbiota. In vivo experiments indicated that CHMACS significantly inhibited proliferation tumorigenicity cells. Further, treatment decreased proportion CD8 + T, natural killer, Th17 HPLC/MS analysis...
Abstract Background Dysmobility syndrome based on osteoporosis (ODS) is a disease characterized by low bone mass and muscle mass. Its features are high fracture fall risk. Falls fractures the most important factors affecting quality of life lifespan ODS. However, there no serum marker for evaluation ODS patients. Our previous studies have shown that expression circulating miRNA stable good diagnosis. Therefore, this study aims to explore potential markers Methods A total 78 subjects were...
<title>Abstract</title> Objective Through a systematic review, compare the differences in characteristic indicators of muscle atrophy commonly used mouse models, including mass, strength, fiber cross-sectional area, and genes such as Murf-1 Atrogin-1. Qualitatively quantitatively explore characteristics various models atrophy. Methods A computer search was conducted databases Pubmed, Embase, Cochrane, CNKI, VIP, Wanfang, Sinomed to collect all literature related sarcopenia with time limit...
Cinobufagin, the primary active compound in toad venom, is commonly used for anti-tumor, anti-inflammatory, and analgesic purposes. However, its specific bone-protective effects remain uncertain. This research aims to ascertain properties of cinobufagin investigate underlying mechanisms.
Ninety-nine percent of alpha-synuclein (α-syn) in the human body is distributed erythrocytes. However, role that α-syn plays erythropoiesis remains unclear. To determine effect on erythroid differentiation, cells, derived from CD34+ progenitors umbilical cord, were cultured a system composed series cytokines and harvested after 6 days. Our work showed inhibition-promoted as characterized by altered activity surface markers development such CD49d, CD36, CD71; different methylation status...