A5087299832- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Kidney Stones and Urolithiasis Treatments
- Congenital Anomalies and Fetal Surgery
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Testicular diseases and treatments
- Intestinal Malrotation and Obstruction Disorders
- Gastrointestinal disorders and treatments
- Hernia repair and management
- Sexual function and dysfunction studies
- Pediatric Hepatobiliary Diseases and Treatments
- Pain Mechanisms and Treatments
- Bladder and Urothelial Cancer Treatments
- Genital Health and Disease
- Ion channel regulation and function
- Renal and related cancers
- Esophageal and GI Pathology
- Appendicitis Diagnosis and Management
- Sexual Differentiation and Disorders
- Pediatric Pain Management Techniques
- Anesthesia and Pain Management
- Congenital Diaphragmatic Hernia Studies
Hôpital Pellegrin
2014-2025
Université de Bordeaux
1999-2025
Centre Hospitalier Universitaire de Bordeaux
2011-2023
Hôpital des Enfants
2009-2019
Neurocentre Magendie
2010
Inserm
2005-2010
Laboratoire de Biologie du Développement
2002
The maintenance of chronic pain states requires the regulation gene expression, which relies on an influx calcium. Calcium through neuronal L-type voltage-gated calcium channels (LTCs) plays a pivotal role in excitation-transcription coupling, but involvement LTCs remains unclear. We used peptide nucleic acid (transportan 10-PNA conjugates)-based antisense strategy to investigate LTC subtypes Ca(V)1.2 and Ca(V)1.3 long-term sensitization rat model neuropathy (spinal nerve ligation). Our...
L-type calcium channels in the CNS exist as two subunit forming channels, Cav1.2 and Cav1.3, which are involved short- long-term plasticity. We demonstrate that Cav1.3 but not is essential for wind-up. These results identify a key conductance responsible short-term sensitization physiological pain transmission. confirm role of model plasticity associated with neuropathic pain. Up-regulation down-regultation underlies switch from physiology to pathology. Finally, present study reveal...
Abstract Aims This study evaluated whether one (or more) of three doses onabotulinumtoxinA were safe and effective to treat neurogenic detrusor overactivity (NDO) in children. Methods was a 48‐week prospective, multicenter, randomized, double‐blind children (aged 5–17 years) with NDO urinary incontinence (UI) receiving treatment (50, 100, or 200 U; not exceed 6 U/kg). Primary endpoint: change from baseline daytime UI episodes. Secondary endpoints: urine volume at first morning...
OnabotulinumtoxinA is an approved treatment for neurogenic detrusor overactivity in adults inadequately managed with anticholinergics, and more recently was children on the basis of a phase 3, 48-week, single-treatment study (NCT01852045). Given paucity long-term pediatric data, we report continued safety these patients after repeated onabotulinumtoxinA treatment.This multicenter, double-blind, repeat-treatment extension (NCT01852058) who entered from preceding study. Data were integrated...
Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management PUV is prenatal prediction postnatal function. Fetal ultrasound and fetal urine biochemistry are currently employed this prediction, but clearly lack precision. We previously developed a peptide signature that predicted utero with high precision function fetuses PUV. describe here objectives design prospective international multicentre ANTENATAL (multicentre validation...
Abstract Deep dorsal horn neurons are involved in the processing of nociceptive information spinal cord. Previous studies revealed a role intrinsic bioelectrical properties (plateau potentials) deep neuron neuronal hyperexcitability, indicating their function pain sensitization. These were considered to rely on L ‐type calcium currents. Two different isotypes channel alpha 1 subunit have been cloned (Ca V 1.2 and Ca 1.3). Both known be expressed However, no data available subcellular...
Conservative management of splenic rupture in haemodynamically stable children is now generally accepted. However, during follow-up, many complications can occur. The aim this study was to describe the we observed and propose a standardised follow-up adapted them.Between March 1992 December 2002 managed 65 (aged between 3 15 years old) with accidental rupture. Follow-up treatment consisted 10-day bed rest sonogram Doppler controls on 5th 10th day subsequently every month until complete...
The authors present a series of six anal canal duplications (ACD), the alimentary tract located along posterior side canal, with perineal opening just behind anus. Five asymptomatic were diagnosed before age one year, by simple inspection. A twelve-year-old girl presented and pains diarrhoea. Fistulography revealed tubular structure in five cases cystic case, normal case communicating it. presacral sacrococcygeal teratoma was found two children it visualised preoperative US an infant...
Posterior urethral valves are leaflets that cause Lower Urinary Tract Obstruction (LUTO) in boys and associated with congenital renal dysplasia abnormal bladder function. They affect 1:4,000 to 1:25,000 births can be responsible for End-Stage Renal Failure childhood. There have been several studies on the effect of pop-off mechanisms posterior valves, but results contradictory. We aimed assess discuss function a large cohort patients.Boys PUV without (urinoma, VURD or giant diverticula) were...
Nm23 has been identified as a gene family encoding different isoforms of nucleoside diphosphate kinase (NDPK). This protein is key enzyme in nucleotide metabolism and shown to play important roles various cellular functions. In the present study, we have investigated expression three isotypes mouse dorsal root ganglia. situ hybridization reverse transcriptase-polymerase chain reaction analysis demonstrated high levels nm23-M1, -M2, -M3 mRNA peripheral nervous tissue. Moreover, also displayed...
While familial forms of complex disorders/differences sex development have been widely reported, data regarding isolated hypospadias are sparse and a family history is thought to be less frequent. We aimed determine the frequency in families boys with hypospadias, establish whether these exhibit particular phenotype evaluate prevalence genetic defects main candidate genes.A total 395 were prospectively screened for standardized questionnaire, extensive clinical description, tree sequencing...
The treatment of acute appendicitis in children is sometimes followed by complications including intra-abdominal abscess, for which the traditional surgical drainage. We evaluated efficacy antibiotic management compared to classic treatment. This retrospective study investigated 22 from 5 13 years age with one or many abscesses after appendectomy, treated between 1992 and 2002. Eleven received surgery other 11 were triple antibiotherapy. two groups comparable. Surgery was efficient 36% cases...
Boys with posterior urethral valves (PUV) present an increased risk of febrile urinary tract infection (fUTI). Identifying specific factors could allow for tailoring UTI prevention. The aim this study was to use the data from CIRCUP randomized controlled trial identify patient characteristics associated a higher fUTI.We performed secondary analysis which included boys PUV, circumcision and antibiotic prophylaxis vs. alone followed 2 years. There only 1 episode fUTI in group 17 uncircumcised...
We participate in humanitarian missions Madagascar during which we treat severe hypospadias. report our experience and results with these patients, conditions, discuss choice of technique this particular setting.We retrospectively reviewed the data 27 patients operated for hypospadias between November 2006 September 2009. Twenty one underwent a modified Koyanagi procedure, three Duckett urethroplasty, two an onlay island flap, augmented tubularised plate urethroplasty. Two who repair also...