A5069338616- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Non-Invasive Vital Sign Monitoring
- Muscle and Compartmental Disorders
- Hospital Admissions and Outcomes
- Emergency and Acute Care Studies
- Appendicitis Diagnosis and Management
- Trauma and Emergency Care Studies
- Electrical and Bioimpedance Tomography
- Renal Transplantation Outcomes and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Climate Change and Health Impacts
- Healthcare Decision-Making and Restraints
- Disaster Response and Management
- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Long-Term Effects of COVID-19
- Ultrasound in Clinical Applications
- Metabolomics and Mass Spectrometry Studies
- Abdominal Surgery and Complications
- Neonatal and Maternal Infections
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- Immune cells in cancer
Hospital Sepaco
2021-2025
Universidade Federal de São Paulo
2005-2024
Hospital São Paulo
2020-2024
Evidence (Italy)
2021
Brazilian Research in Intensive Care Network
2021
Latin American Sepsis Institute
2020
Objective: Outcomes of low-risk patients may be affected by the overall acuity ICU to which they were admitted. Studies addressing this topic are very scarce and underlying mechanisms supporting association remain incompletely understood. Here, we investigated effects (defined as mean Simplified Acute Physiology Score 3 all admitted in bimester a given patient was admitted) organizational factors on outcomes with low risk dying ICUs. Design: Retrospective cohort study. Setting: One hundred...
Slower intravenous fluid infusion rates could reduce the formation of tissue edema and organ dysfunction in critically ill patients; however, there are no data to support different during challenges for important outcomes such as mortality.To determine effect a slower rate vs control on 90-day survival patients intensive care unit (ICU).Unblinded randomized factorial clinical trial 75 ICUs Brazil, involving 11 052 requiring at least 1 challenge with risk factor worse were from May 29, 2017,...
Rationale: Although proposed as a clinical prompt to sepsis based on predictive validity for mortality, the Quick Sepsis-related Organ Failure Assessment (qSOFA) score is often used screening tool, which requires high sensitivity.Objectives: To assess accuracy of qSOFA mortality in Brazil, focusing sensitivity.Methods: We prospectively collected data from two cohorts emergency department and ward patients. Cohort 1 included patients with suspected infection but without organ dysfunction or...
Sepsis is a global health emergency, which caused by various sources of infection that lead to changes in gene expression, protein-coding, and metabolism. Advancements "omics" technologies have provided valuable tools unravel the mechanisms involved pathogenesis this disease. In study, we performed shotgun mass spectrometry peripheral blood mononuclear cells (PBMC) from septic patients (N=24) healthy controls (N=9) combined these results with two public microarray leukocytes datasets....
Hypoxia inducible factor 1 alpha (HIF-1α) is linked to the metabolic and immune alterations in septic patients. Stabilization of HIF-1α by hypoxia or inflammation promotes expression several genes related glycolytic metabolism, angiogenesis, coagulation, cell proliferation, apoptosis. Here, we analyzed public available blood transcriptome datasets from patients evaluated PCR array other responsive peripheral mononuclear cells with sepsis secondary community acquired infections. Samples were...
Purpose of review Herein, we conducted a the literature to better understand issue prolonged emergency department (ED) boarding by providing an overview current evidence on available causes, consequences, and mitigation strategies. Recent findings Severely ill patients awaiting transfer intensive care units (ICU) imposes additional burdens team from both clinical management perspective. The reasons for ED are multifactorial. compromises patients’ safety outcomes, is associated with increased...
The optimal amount for initial fluid resuscitation is still controversial in sepsis and the contribution of non-resuscitation fluids balance unclear. We aimed to investigate main components intake both survivors non-survivor patients with septic shock within first 72 hours. In this prospective observational study two intensive care units, we recorded all administered intravenously, orally, or enterally, losses during specific time intervals from vasopressor initiation: T1 (up 24 hours), T2...
After the early phase of sepsis, excessive fluid administration may worsen pulmonary edema and prolong mechanical ventilation [1]. Accurately predicting responsiveness obviates unnecessary loading, helps to detect patients who benefit from a volume expansion. Pulse pressure variation (DPP) is reliable predictor in mechanically ventilated only when tidal at least 8 ml/kg [2]. The aim this study was evaluate predictive value DPP for after maneuver change with 6 ml/kg.
To evaluate whether changes in central venous pressure during fluid expansion and baseline cyclic respiratory variation the amplitude (RespCVP) curve could be used to discriminate between responders nonresponders.
RESUMO Objetivo: Avaliar se as variações na pressão venosa central durante a expansão volêmica e variação respiratória cíclica basal curva de amplitude da poderiam ser usadas para discriminar entre pacientes responsivos não fluidos. Métodos: Trata-se um estudo observacional prospectivo que incluiu adultos em estado crítico foram submetidos à forma infusão ou desafio volêmico cristaloides. Todos os estavam ventilação mecânica devidamente sedados. Determinamos (PVCT0) 5 (ΔPVCT5), 10 (ΔPVCT10)...
To describe the effects of balanced solution use on short-term outcomes patients with traumatic brain injury enrolled in BaSICS trial.
Background: Reliable surveillance methods are indispensable for benchmarking of healthcare-associated infection rates.The National Healthcare Safety Network (NHSN) recently introduced ventilator-associated events (VAE), including conditions (VAC) [1].This new algorithm is amenable to automated implementation and strives more consistent interpretation.We assess the feasibility reliability implementation.Materials methods: Retrospective analysis an ICU cohort with prospective assessment...
Introduction Neutrophils play a major role in sepsis-induced organ dysfunction, especially the lung.HMGB1 has emerged as late cytokine and is implicated perpetuation of inflammatory stimulus dysfunction development well.There are limited data about neutrophil response patterns to HMGB1 septic patients, whether those could be different from following LPS exposure.Objectives To evaluate differences gene expression activation NF-κB, Akt, p38MAPK blood neutrophils patients exposed LPS; compare...
Introduction Septic patients frequently develop critical illness myopathies (CIMs) that may represent a crucial factor for prolonged intensive care unit treatment and ventilator weaning delay.Experimental fi ndings have identifi ed oxidative stress plays role in causing muscle depletion chronic pathological states like sepsis.It is well documented regular moderate physical exercise can decreased enhance antioxidant functions.Objective To investigate whether training reduces damage septic...