A5030307191- Inflammasome and immune disorders
- Streptococcal Infections and Treatments
- Oral microbiology and periodontitis research
- Hydrogen's biological and therapeutic effects
- Medical and Biological Ozone Research
- Helicobacter pylori-related gastroenterology studies
- Laser Applications in Dentistry and Medicine
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Fatty Acid Research and Health
- Immune cells in cancer
- Gastroesophageal reflux and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- interferon and immune responses
- Fungal Infections and Studies
- Cytomegalovirus and herpesvirus research
- Adipose Tissue and Metabolism
- Galectins and Cancer Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal and Maternal Infections
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
Tokyo Medical and Dental University
2018-2024
The University of Tokyo
2022-2023
Abstract Long-term infection of the stomach with Helicobacter pylori can cause gastric cancer. However, mechanisms by which bacteria adapt to environment are poorly understood. Here, we show that a small non-coding RNA H. (HPnc4160, also known as IsoB or NikS) regulates pathogen’s adaptation host well bacterial oncoprotein production. In rodent model infection, genomes isolated from possess an increased number T-repeats upstream HPnc4160-coding region, and this leads reduced HPnc4160...
Abstract Clinical studies have shown that Aggregatibacter actinomycetemcomitans ( A. ) is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis (RA). However, the mechanism poorly understood. Here, we show systemic infection triggers progression of in mice anti-collagen antibody-induced (CAIA) model following IL-1β secretion cell infiltration paws a manner dependent on caspase-11-mediated inflammasome activation macrophages. The...
Abstract Porphyromonas gingivalis is a Gram‐negative anaerobic bacterium that has been considered to be one of the bacteria associated with progression human periodontitis. Subgingival biofilms formed by bacteria, including P. , induce chronic inflammation, and activation inflammasome in gingival tissue. However, mechanisms gingivalis‐ triggering role bacteria–host interactions are controversial. In this study, we investigated potential for cells mouse models. We demonstrated secreted or...
Preventing adverse pregnancy outcomes is crucial for maternal and child health. Periodontal disease a risk factor many systemic diseases including outcomes, such as preterm birth low weight. In addition, the administration of periodontopathic bacterium
Clostridium perfringens (C. perfringens) is Gram-positive anaerobic, spore-forming rod-shaped bacterial pathogen that widely distributed in nature. This bacterium known as the causative agent of a foodborne illness and gas gangrene. While major virulence factors are alpha-toxin perfringolysin O (PFO) produced by type A strains C. perfringens, precise mechanisms how these toxins induce development gangrene still not well understood. In this study, we analyzed host responses to toxins,...
Caspase activation results in pyroptosis, an inflammatory cell death that contributes to several diseases by releasing cytokines and cellular contents. Fusobacterium nucleatum is a periodontal pathogen frequently detected human cancer bowel diseases. Studies have reported F. infection leads NLRP3 but the precise process disease association remain poorly understood. This study demonstrated exacerbates acute colitis mice activates pyroptosis through caspase-11-mediated gasdermin D cleavage...
Periodontitis is a chronic inflammatory disease caused by oral microorganisms in the subgingival biofilm. Stable aqueous ozone ultrafine bubble water (OUFBW) has recently begun to be used as an antiseptic treatment of periodontitis. The effectiveness OUFBW thought depend on bactericidal actions dissolved exerted via its oxidizing effect. On other hand, effects periodontal tissues are largely unknown. In this paper we examined cellular responses after treatment. Human primary ligament...
Group A Streptococcus (GAS) secretes deoxyribonucleases and evades neutrophil extracellular killing by degrading traps (NETs). However, limited information is currently available on the interaction between GAS NETs in pathogenicity of pharyngitis. In this study, we modified a mouse model pharyngitis revealed an essential role for DNase model. After intranasal infection, nasal mucosa was markedly damaged near cavity, at which surrounded neutrophils. When neutrophils were depleted from mice,...
<title>Abstract</title> Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobic bacterium, is the most common cause of periodontitis. P. secretes several virulence factors, such as gingipains, LPS, and OMVs, which potentially induce release inflammatory cytokines IL-1β, TNFα, IL-6 through inflammasome activation TLRs. Previous reports have suggested that host response to infection induces progression autoimmune diseases, including multiple sclerosis. We demonstrated enhancement...
Periodontitis, a chronic inflammatory disease of periodontal tissue, is often associated with group pathogenic bacteria known as the "red complex," including Tannerella forsythia (T. forsythia). Previous papers showed that T. induces many kinds cytokines IL-1β regulated by inflammasome activation. However, physiological function for periodontitis and mechanism to induce activation infection are poorly understood. In this study, we demonstrate NLRP3 caspase-4 essential infection, playing...
Buruli ulcer is an emerging chronic infectious skin disease caused by Mycobacterium ulcerans. Mycolactone, exotoxin produced the bacterium, only identified virulence factor so far, but functions of this toxin and mechanisms progression remain unclear. By interfering Sec61 translocon, mycolactone inhibits Sec61-dependent co-translational translocation newly synthesized proteins, such as induced cytokines immune cell receptors, into endoplasmic reticulum. However, in regard to IL-1β, which...
Abstract Type-1 carcinogenic Helicobacter pylori that is known to evolve during long-term infection, enters the stomach orally and causes gastric cancer using protein CagA 1 . However, little about adaptation mechanisms of H. when environment changes from outside inside living body. Here we show small non-coding RNA HPnc4160 a crucial novel molecule negatively regulates bacterial-host cancer. isolated gerbil’s stomachs eight weeks post-infection acquired mutations in increased number...
<title>Abstract</title> Clinical studies have shown that Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis (RA). However, the mechanism poorly understood. Here, we show systemic infection A. triggers progression of in mice anti-collagen antibody-induced (CAIA) model following IL-1β secretion cell infiltration paws a manner dependent on caspase-11-mediated inflammasome...
Clinical studies have shown that Aggregatibacter actinomycetemcomitans is associated with juvenile severe periodontitis and potentially aggravates rheumatoid arthritis (RA). However, the functional contribution of infection by A. poorly understood. Here, we show systemic exacerbates a change in bone density mice following IL-1β secretion macrophages caspase-11-mediated inflammasome dependent manner. We also demonstrated LPS from activates directly. Administration polymyxin B, chloroquine,...