A5063900168- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Colorectal Cancer Screening and Detection
- Genetic Associations and Epidemiology
- Advanced MRI Techniques and Applications
- Cardiovascular Effects of Exercise
- Gastric Cancer Management and Outcomes
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Pregnancy and preeclampsia studies
- Colorectal Cancer Surgical Treatments
- Fault Detection and Control Systems
- Computational Drug Discovery Methods
- Cardiomyopathy and Myosin Studies
- Birth, Development, and Health
- Connexins and lens biology
- Body Contouring and Surgery
- Radiology practices and education
- Case Reports on Hematomas
- Viral Infections and Immunology Research
- Bariatric Surgery and Outcomes
Imperial College London
2014-2024
Lung Institute
2022-2024
Maastricht University
2024
Imperial College Healthcare NHS Trust
2023
St Mark's Hospital
2014-2019
British Heart Foundation
2012-2018
Northwick Park Hospital
2018
University College London
2014-2017
St George's Hospital
2017
St George's Hospital
2017
Importance Hypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity observationally associated with future risk cardiovascular disease. However, observational results may be subject to residual confounding bias. Objective To investigate the association HDPs multiple diseases. Design, Setting, Participants A genome-wide genetic study using mendelian randomization (MR) was performed from February 16 March 4, 2022. Primary analysis conducted...
Maternal cardiovascular risk factors have been associated with adverse maternal and fetal outcomes. Given the difficulty in establishing causal relationships using epidemiological data, we applied Mendelian randomization to explore role of on developing preeclampsia or eclampsia, low birthweight.
Background: Gaining access to the peritoneal cavity is a critical step in laparoscopic surgeries and associated with risk of complications. The two most commonly used techniques for pneumoperitoneum creation are open (Hasson cannula) closed (Veress needle) methods. This study aims compare these terms procedural efficiency, intraoperative postoperative complications, long-term outcomes. Methods: randomized controlled trial included 50 patients undergoing elective at tertiary care hospital....
Background— The mechanisms of reduced angina on second exertion in patients with coronary arterial disease, also known as the warm-up phenomenon, are poorly understood. Adaptations within and systemic circulations have been suggested but never demonstrated vivo. In this study we measured central hemodynamics during serial exercise. Methods Results— Sixteen (15 male, 61±4.3 years) a positive exercise ECG exertional completed protocol. During cardiac catheterization via radial access, they...
The features of the hypertrophic cardiomyopathy (HCM) ECG make it a challenge for subcutaneous implantable cardioverter-defibrillator (S-ICD) screening. We aimed to investigate causes screening failure at rest and on exercise inform optimal S-ICD vector development.One hundred thirty-one HCM patients (age, 50±16 years; 92 males 39 females) with ≥1 risk factor sudden death underwent exercise. Fifty (38%) were ineligible because in every lead vector: 33 (66%) failed supine position, 12 (24%)...
There is increasing focus on applying deep learning methods to electrocardiograms (ECGs), with recent studies showing that neural networks (NNs) can predict future heart failure or atrial fibrillation from the ECG alone. However, large numbers of ECGs are needed train NNs, and many currently only in paper format, which not suitable for NN training. We developed a fully-automated online digitisation tool convert scanned into digital signals. Using automated horizontal vertical anchor point...
It remains unclear whether the association between obstructive sleep apnoea (OSA), a form of sleep-disordered breathing (SDB), and atrial fibrillation (AF) is causal or mediated by shared co-morbidities such as obesity. Existing observational studies are conflicting limited confounding reverse causality. We performed Mendelian randomisation (MR) to investigate relationships SDB, body mass index (BMI) AF. Single-nucleotide polymorphisms associated with SDB (n = 29) BMI 453) were selected...
Abstract Introduction Colorectal cancer (CRC) is uncommon in patients under the age of 40 years and its association with poor histological features survival uncertain. This study aimed to evaluate age‐related differences clinicopathological prognosis diagnosed CRC. Method A single‐centre retrospective review all CRC between 2004 2013 was performed. Patients were stratified into three groups: (1) 18–40 years, (2) 41–60 (3)> 60 years. Clinicopathological characteristics outcomes compared...
Background and study aims Colonic polypectomy is acknowledged to be a technically challenging part of colonoscopy. Training in recognized often inconsistent. This aimed ascertain worldwide practice training. Patients methods An electronic survey was distributed endoscopic trainees trainers 19 countries asking about their experiences receiving delivering Participants were also asked whether formal training guidance existed country. Results Data obtained from 610 colonoscopists. Of these...
Observational studies suggest that electrocardiogram (ECG) indices might be influenced by obesity and other anthropometric measures, though it is difficult to infer causal relationships based on observational data due risk of residual confounding. We utilized mendelian randomization (MR) explore relevance multiple measures P-wave duration (PWD), PR interval, QRS duration, corrected QT interval (QTc).Uncorrelated (r2 < 0.001) genome-wide significant (p 5 × 10-8) single nucleotide...
Abstract Aims Although electrical activity of the normal human heart is well characterized by electrocardiogram, detailed insights into within-subject and between-subject variations ventricular activation recovery noninvasive electroanatomic mapping are lacking. We epicardial within between subjects using non-invasive electrocardiographic imaging (ECGI) as a basis to better understand pathology. Methods results Epicardial were assessed ECGI in 22 subjects, 4 with bundle branch block (BBB)...
Understanding the mechanism sustaining cardiac fibrillation can facilitate personalization of treatment. Granger causality analysis be used to determine existence a hierarchical that is more amenable ablation treatment in time-series data. Conventional based on linear predictability may fail if assumption not met or given sparsely sampled, high-dimensional More recently developed information theory-based measures could potentially provide accurate estimate nonlinear coupling. However,...
Although obesity, defined by body mass index (BMI), has been associated with a higher risk of hospitalisation and more severe course illness in Covid-19 positive patients amongst the British population, it is unclear if this translates into increased mortality. Furthermore, given that BMI an insensitive indicator adiposity, effect adipose volume on outcomes also unknown.We used UK Biobank repository, which contains clinical anthropometric data linked to Public Health England healthcare...
Background Survivors of myocardial infarction are at increased risk late ventricular arrhythmias, with infarct size and scar heterogeneity being key determinants arrhythmic risk. Gap junctions facilitate the passage small ions morphogenic cell signaling between myocytes. We hypothesized that gap enhancement during infarction-reperfusion modulates structural electrophysiological remodeling reduces arrhythmogenesis. Methods Results Infarction-reperfusion surgery was carried out in male...
Obesity is associated with electrophysiological remodeling, which manifests as detectable changes on the surface electrocardiogram (ECG).To develop neural networks (NN) to predict body mass index (BMI) from ECGs and test hypothesis that discrepancies between NN-predicted BMI measured are indicative of underlying adiposity and/or concurrent cardiometabolic ill-health.NN models were developed using 36,856 12-lead resting UK Biobank. Two architectures for continuous categorical estimation...
Background A minority of acute coronary syndrome (ACS) cases are associated with ventricular arrhythmias (VA) and/or cardiac arrest (CA). We investigated the effect VA/CA at time ACS on long-term outcomes. Methods and Results analyzed routine clinical data from 5 National Health Service trusts in United Kingdom, collected between 2010 2017 by Institute for Research Informatics Collaborative. total 13 444 patients ACS, 376 (2.8%) whom had concurrent VA, survived to hospital discharge were...