A5015620408- Cardiac, Anesthesia and Surgical Outcomes
- Cutaneous lymphoproliferative disorders research
- Anesthesia and Pain Management
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Pain Management and Opioid Use
- Viral-associated cancers and disorders
- Maternal and fetal healthcare
- Cytomegalovirus and herpesvirus research
- Pregnancy and preeclampsia studies
- Bariatric Surgery and Outcomes
- Infection Control and Ventilation
- Maternal and Perinatal Health Interventions
- Endoplasmic Reticulum Stress and Disease
- Pain Mechanisms and Treatments
- Enhanced Recovery After Surgery
- COVID-19 and healthcare impacts
- Lipid metabolism and biosynthesis
- Building Energy and Comfort Optimization
- Global Health Workforce Issues
- Histiocytic Disorders and Treatments
- Calcium signaling and nucleotide metabolism
- Global Maternal and Child Health
- Cardiac Health and Mental Health
- Extracellular vesicles in disease
University of Toronto
2023-2024
University of Alberta
2021-2024
Kingston Health Sciences Centre
2024
Queen's University
2022-2024
First Affiliated Hospital of Jinan University
2024
University Health Network
2023
St. Michael's Hospital
2023
University of Ottawa
2023
Toronto General Hospital
2023
Ottawa Hospital
2023
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19) pandemic and there an urgent need to understand cellular response SARS-CoV-2 infection. Beclin 1 essential scaffold autophagy protein that forms two distinct subcomplexes with modulators Atg14 UVRAG, responsible autophagosome formation maturation, respectively. In present study, we found infection triggers incomplete response, elevated but impaired declined by genetic...
Chronic postsurgical pain is a common complication of surgery. The role psychologic risk factors like depression and anxiety substantially understudied in cardiac This study sought to identify perioperative associated with chronic at 3, 6, 12 months after authors hypothesize that baseline vulnerabilities have negative influence on pain.The prospectively collected demographic, psychologic, cohort 1,059 patients undergoing surgery the Toronto General Hospital between 2012 2020. Patients were...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leads to the accumulation of lipid droplets (LD), central hubs metabolism, in vitro or type II pneumocytes and monocytes from coronavirus disease 19 (COVID-19) patients blockage LD formation by specific inhibitors impedes SARS-CoV-2 replication. Here, we showed that ORF3a is necessary sufficient trigger during infection, leading efficient virus Although highly mutated evolution, ORF3a-mediated modulation conserved most...
The physiology of diabetes mellitus can increase the risk perioperative aspiration, but there is limited and contradictory evidence on incidence "full stomach" in fasting diabetic patients. aim this study to assess baseline gastric content (using ultrasound) nondiabetic patients scheduled for elective surgery who have followed standard preoperative instructions.
ABSTRACT Objective To elucidate the regional distribution of metabolic dysfunction‐associated steatohepatitis (MASH) fibrosis within liver and to identify potential therapeutic targets for MASH fibrosis. Methods Liver sections from healthy controls, patients with simple steatosis were analysed using spatial transcriptomics integrated single‐cell RNA‐seq. Results Spatial analysis tissues revealed that fibrotic region (Cluster 9) was primarily distributed in lobules, some also found...
RSK1, an essential cellular kinase for Kaposi’s sarcoma-associated herpesvirus (KSHV) replication, is highly phosphorylated and SUMOylated during KSHV lytic cycle, which determine the substrate phosphorylation specificity of respectively. However, SUMO E3 ligase responsible attaching to RSK1 has not yet been identified. By genome-wide screening, we found that ORF45 necessary sufficient enhance SUMOylation. Mechanistically, binds SUMOs via two classic SUMO-interacting motifs (SIMs) functions...
There is substantial evidence showing that medical student wellness a worsening problem in Canada. It apparent students' deteriorates throughout their training. Medical schools and governing bodies are responding by integrating into competency frameworks accreditation standards through combination of system- individual-level approaches. System-level strategies consider how policies, culture, the "hidden curriculum" impact wellness, essential for reducing burnout prevalence achieving optimal...
BACKGROUND: The Affordable Care Act has been associated with increased Medicaid coverage for childbirth among low-income US women. We hypothesized that expansion was use of labor neuraxial analgesia. METHODS: performed a cross-sectional analysis women singleton live births who underwent vaginal delivery or intrapartum cesarean between 2009 and 2017. Data were sourced from in 26 states used the 2003 Revised Birth Certificate. Difference-in-difference linear probability models to compare...
Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma, which in early patch/plaque stages runs an indolent course. However, ~25% of patients with MF develop skin tumours, a hallmark progression to advanced stage, associated high mortality. The mechanisms involved stage are poorly elucidated.We sought address hypothesis cell trafficking between lesions by comparing transcriptomic profiles samples different clinical MF.We performed whole-transcriptome and whole-exome sequencing...
RSK1, a downstream kinase of the MAPK pathway, has been shown to regulate multiple cellular processes and is essential for lytic replication variety viruses, including Kaposi’s sarcoma-associated herpesvirus (KSHV). Besides phosphorylation, it not known whether other post-translational modifications play an important role in regulating RSK1 function. We demonstrate that undergoes robust SUMOylation during KSHV at lysine residues K110, K335, K421. SUMO modification does alter activation...
Background: Reducing the prevalence of eclampsia, a major cause maternal and perinatal morbidity, is health priority. However, sparse data exist examining trends in USA eclampsia. Objective: The aim this study was to assess temporal eclampsia among live births United States from 2009 2017. Study design: This population-based cross-sectional included 41 states District Columbia between all women, women with chronic hypertension hypertensive disorders pregnancy were reported by 1000 births....
Abstract The COVID-19 pandemic has led to persistent supply shortages of respiratory protective equipment in many jurisdictions. Reusable industrial respirators have been proposed and deployed as an alternative, but also face severe limitations. In addition, do not filter the user’s expired breath, a major limitation health care settings where bidirectional protection is required. We present development quantitative testing reusable silicone respirator that can be locally manufactured using...