A5100337910- Immune Cell Function and Interaction
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- Radiomics and Machine Learning in Medical Imaging
- Immunodeficiency and Autoimmune Disorders
- Ergonomics and Musculoskeletal Disorders
- Statistical Methods in Clinical Trials
- Cancer-related molecular mechanisms research
- Bone Tumor Diagnosis and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Resilience and Mental Health
- Hepatocellular Carcinoma Treatment and Prognosis
- Intestinal Malrotation and Obstruction Disorders
- Protease and Inhibitor Mechanisms
- Polyomavirus and related diseases
- Cancer survivorship and care
- Ginseng Biological Effects and Applications
- Soft tissue tumor case studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiovascular Disease and Adiposity
Sichuan University
2018-2023
West China Hospital of Sichuan University
2018-2023
Fujian Medical University
2023
First Affiliated Hospital of Xiamen University
2023
Xiamen University
2023
Princess Margaret Cancer Centre
2020-2023
University Health Network
2020-2023
University of Toronto
2020-2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023
Liaoning Normal University
2023
Abstract Background The elevation of plasma D‐dimer levels may predict a higher risk thrombosis and play role in the pathological process patients after spontaneous intracerebral hemorrhage (ICH). However, its function predicting prognosis ICH has not been verified on large cases. Patients Methods Retrospective cohort study 1,332 consecutive with at an academic medical center was conducted. Functional outcome three months dichotomized using modified Rankin Scale (0–2 versus 3–6). level blood...
Background. Multiple organ failure (MOF) may lead to an increased mortality rate of moderately severe (MSAP) or acute pancreatitis (SAP). This study is aimed use machine learning predict the risk MOF in course disease. Methods. Clinical and laboratory features with significant differences between patients without were screened out by univariate analysis. Prediction models developed for selected through six methods. The internally validated a five-fold cross-validation, series optimal feature...
Patient perspectives are fundamental to defining tolerability of investigational anti-neoplastic therapies in clinical trials. Phase I trials present a unique challenge designing tools for efficiently collecting patient-reported outcomes (PROs) given the difficulty anticipating adverse events relevance. However, phase also offer an opportunity investigators optimize drug dosing based on future larger-scale and eventual practice. Existing comprehensively capturing PROs generally cumbersome...
Summary Post‐transplant lymphoproliferative disorder (PTLD) may arise after solid organ transplantation, and the most common subtype resembles diffuse large B cell lymphoma (DLBCL). In DLBCL‐type PTLD, anti‐CD20 antibody rituximab (R) be combined with chemotherapy (R‐CHOP) or use a strategy (R‐primary; similar to PTLD‐1 clinical trial) consisting of induction four weekly doses R‐alone, without any sequential R‐CHOP follow‐up. Here we report on multicentre retrospective cohort transplant...
Abstract There is currently no standard therapeutic regimen available for patients with advanced colorectal cancer in whom the disease continues to progress after 2 or more lines of chemotherapy. The purpose this study investigate efficacy and safety apatinib at least two prior chemotherapy had failed. Twenty seven who failed were treated (500 mg/day). As a comparison control, 26 comparable clinical baseline characteristics including age, sex, Eastern Cooperative Oncology Group (ECOG) score,...
We sought to characterize and assess differences in compositions of intestinal flora between patients with rheumatoid arthritis (RA) their respective spouses. 80 volunteers were recruited, including 30 pairs RA spouses, 20 healthy individuals. Fresh stool samples collected, processed, 16S rRNA-sequencing was performed. Data analysed using an operational taxonomic units-based method, community structure assessments Community composition analysis indicated that there similar microbiota...
IgG4-related disease (IgG4-RD) is a recently recognized systemic fibro-inflammatory of unknown cause involving many organs including pancreas, salivary glands, and lymph nodes. Chronic tuberculosis (TB) infection has been reported in IgG4-RD, but the prevalence TB not evaluated IgG4-RD. Characterization patient with IgG4-RD by physical examination, laboratory tests, magnetic resonance imaging (MRI) histological examination. was medical history, radiological examinations, sputum tubercular...
Objectives: To measure the resilience of elderly patients with first ischemic stroke in mainland China and to identify variables that may be correlated at acute stage hospitalization.Methods: A cross-sectional survey was carried out departments neurology two tertiary hospitals, where a convenience sample one hundred forty-seven voluntarily participated our study. Resilience assessed using Chinese version Connor-Davidson Scale three dimensions (tenacity, strength, optimism). The General...
Background and purposeTo evaluate longitudinal patient-reported distress in cervical cancer patients treated with definitive chemoradiation (CRT).Materials methodsBetween 2011 2016, consenting CRT who completed ≥ 2 revised Edmonton Symptom Assessment System (ESAS-r) questionnaires at clinical visits, including baseline, were included. A linear mixed model was used to assess the trend ESAS-r. minimal clinically important difference (MCID) for total ESAS-r score defined as a change of 3-points...
Abstract This study examined the impact of an attractive voice compared to unattractive in economic game. Results showed that proposers with were perceived as more reasonable their monetary allocations and less likely receive punishment for unfair allocation.
BACKGROUND: Staggered seats are a solution for the Flying-V aircraft, where cabin’s longitudinal axis has 26 degrees angle with respect to direction of flight, compensate an otherwise oblique sitting position. However, little is known on acceptable pitches in this staggered configuration. OBJECTIVE: The goal research evaluate comfort different that relative axis. METHODS: Two rows positioned at three (27, 29 and 31 inches). 53 participants were seated each setup. For each, questionnaire was...
Background: The pathogenesis of common variable immunodeficiency disorder (CVID) is complex, especially when combined with autoimmunity. Genetic factors may be potential explanations for this complex situation, and whole genome sequencing (WGS) provide the basis potential. Methods: information patients CVID autoimmunity, together their first-degree relatives, was collected through WGS. association between genetic clinical phenotypes studied using analysis strategies such as sporadic...
Antibody deficiency is a type of primary immunodeficiency that often manifests as hypogammaglobulinemia, with or without repeated infections. Although appears to be contrary autoimmunity, they usually occur simultaneously, and the specific pathogenesis remains unknown. We herein describe an adult patient autoimmune manifestations recurrent The case was characterized by sustained decrease in serum immunoglobulin A, accompanied decreased T lymphocytes, B monocytes, platelets peripheral blood...
Objective To explore the risk factors of postoperative pulmonary infection in patients with craniocerebral injury and establish a nomogram model to predict after injury. Methods The clinical data 169 injury, admitted underwent craniotomy our hospital from January 2013 December 2018, were retrospectively analyzed. The without compared. analyzed by multivariate Logistic regression. R language was used injury. Receiver operating characteristic (ROC) curve prediction efficiency for...
2014 Background: Typically symptomatic adverse events (sy-AEs) on clinical trials are reported by clinicians using the CTCAE. To complement clinician collected sy-AEs and understand tolerability better, patient report outcome version of CTCAE (PRO-CTCAE) has been developed to provide (pt) perspective severity AEs (graded scale 0-4) their interference in daily life (scale 0-4). The aim this study was correlate PRO responses with grade (G) AEs, dose interruptions/reductions limiting toxicities...
Objective To investigate the correlations of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with ischemic stroke and hyperuricemia in Chinese Han population Shandong, China. Methods The patients acute age- sex-matched controls China were enrolled. Polymerase chain reaction amplification microarray hybridization used to detect MTHFR polymorphism, serum uric acid concentration was measured. Results A total 145 age-and The proportion diabetes (26.90% vs. 6.89%;...