A5041335882- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
- Inhalation and Respiratory Drug Delivery
- Inflammasome and immune disorders
- Adrenal Hormones and Disorders
- Antimicrobial Peptides and Activities
- Thermal Regulation in Medicine
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
Universitat de Barcelona
2022-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2022-2025
Hospital Clínic de Barcelona
2022-2023
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2023
Fundació Clínic per a la Recerca Biomèdica
2023
Abstract Background Streptococcus pneumoniae , a primary cause of community-acquired pneumonia (CAP), is typically treated with β-lactams and macrolides or quinolones. Corticosteroids are now recommended as adjunctive therapy in severe CAP to improve outcomes. I n this prospective randomized animal study, we evaluated the bactericidal efficacy various antibiotic regimens combined corticosteroids using porcine pneumococcal model. Results In 30 White-Landrace female pigs, was induced by...
Pseudomonas aeruginosa pneumonia is commonly treated with systemic antibiotics to ensure adequate treatment of multidrug resistant (MDR) bacteria. However, intravenous (IV) often achieve suboptimal pulmonary concentrations. We therefore aimed evaluate the effect inhaled amikacin (AMK) plus IV meropenem (MEM) on bactericidal efficacy in a swine model monolateral MDR P. pneumonia.We ventilated 18 pigs for up 102 h. At 24 h after bacterial challenge, animals were randomized receive 72 either...
The effect of systemic treatment ventilator-associated pneumonia (VAP) with telavancin, a semisynthetic lipoglycopeptide good penetration in vitro biofilms, has not been tested vivo during mechanical ventilation. This study examined the efficacy telavancin compared linezolid against endotracheal tube (ETT) biofilms porcine model methicillin-resistant Staphylococcus aureus (MRSA) VAP.
<b>Introduction:</b> We recently demonstrated the potential of engineered live bacteria against <i>Pseudomonas</i><i>aeruginosa</i><i>ex vivo</i> biofilms grown in endotracheal tubes (ETT) from patients with ventilator-associated pneumonia (VAP)<sup>1,2</sup> (Fig.1A). <b>Aim:</b> To test vivo efficacy genetically modified <i>Mycoplasma</i><i>pneumoniae</i> strain (CV8_HA_P1) <i>P. aeruginosa</i> ETT-biofilms mechanically ventilated pigs VAP. <b>Methods:</b> Fourteen previously infected...
<b>Background:</b> SARS-CoV-2 physiopathology is linked to an uncontrolled response of the immune system besides a hyper-coagulopathy status. <b>Aim:</b> To characterize phenotypes according inflammatory and cardiac biomarkers. <b>Methods:</b> Patients admitted Hospital Clinic Barcelona due COVID-19 infection between 28<sup>th</sup> January 14<sup>th</sup> June 2021 were prospectively included. A blood sample during first 48h from hospital admission was collected for each patient measure...