A5055702199- Sarcoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cardiac tumors and thrombi
- Cancer Genomics and Diagnostics
- Animal Disease Management and Epidemiology
- T-cell and Retrovirus Studies
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Vector-Borne Animal Diseases
- Gastric Cancer Management and Outcomes
- Extracellular vesicles in disease
- Viral-associated cancers and disorders
- Intraperitoneal and Appendiceal Malignancies
- Mosquito-borne diseases and control
- Cardiac Fibrosis and Remodeling
- Esophageal Cancer Research and Treatment
- Aortic Disease and Treatment Approaches
- CNS Lymphoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Adrenal and Paraganglionic Tumors
- Vascular Malformations and Hemangiomas
Istituto Oncologico Veneto
2016-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2024
University of Padua
2015
University of Cagliari
2004
University of Ferrara
2004
University of Trieste
2004
Anti-HER2 monoclonal antibody trastuzumab improves the survival of those patients with advanced gastroesophageal adenocarcinoma (GEA) exhibiting HER2/ERBB2 overexpression/amplification. The current gold standard methods used to diagnose HER2 status in GEA are immunohistochemistry (IHC) and silver or fluorescence situ hybridization (SISH FISH). However, they do not permit spatial temporal tumor monitoring, nor overcome intra-cancer heterogeneity. Droplet digital PCR (ddPCR) was implement...
Interpatient clinical variability in soft-tissue sarcomas (STS) highlights the need for novel prognostic markers supporting patient risk stratification. As might exhibit a more mesenchymal or epithelial state, we focused on epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT/MET) clues, selected three histotypes with variable aggressiveness.The expression of EMT/MET-related factors was measured by qRT-PCR 55 tumor samples from patients leiomyosarcoma, myxofibrosarcoma,...
We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation antiretroviral therapy (ART). Baseline characteristics this IRIS-KS case, within cohort 12 naïve AIDS-KS patients, were analyzed. No statistically significant differences CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load peripheral blood mononuclear cells...
Gastroesophageal adenocarcinoma (GEA) patients with the microsatellite instability (MSI) subtype emerged as optimal candidates for immunotherapy. To date, immunohistochemistry (IHC) is gold standard MSI assessment in formalin-fixed paraffin-embedded (FFPE) specimens. However, IHC, although useful diagnostic typing, cannot be used to analyze cell-free DNA (cfDNA) liquid biopsy, a tool that could overcome tumor heterogeneity and enable longitudinal monitoring. In order find an alternative...
Abstract The aim of this study was to identify circulating microRNAs (miRNAs) that could be used as biomarkers in patients at risk for or affected by AIDS‐Kaposi's sarcoma (KS). Screening 377 miRNAs performed using low‐density arrays pooled plasma samples 10 HIV/human herpesvirus 8 (HHV8)‐infected asymptomatic and AIDS‐KS before after successful combined antiretroviral therapy (cART). MiR‐375 identified a potential marker active KS, being the most down‐regulated cART up‐regulated naïve...
Adult T cell leukemia/lymphoma (ATLL) is a mature malignancy associated with human leukemia virus type 1 (HTLV-1) infection. Among its four main clinical subtypes, the prognosis of acute and lymphoma variants remains poor. The long latency (3-6 decades) low incidence (3-5%) ATLL imply involvement viral host factors in full-blown malignancy. Despite multiple preclinical studies, contribution stromal microenvironment development not yet completely unraveled. aims this study were to investigate...
Abstract Flaviviridae are an important family of viruses, responsible for widely spread diseases such as dengue and West Nile fever hepatitis C. Despite the severity related diseases, no effective antiviral treatments infection available. Following our discovery adenosine-hindered analogs potent antiflaviviridae agents, we have continued investigation on guanosine inosine derivatives, which were evaluated activity against BVDV, YFV, DENV, WNV viruses in cell-based assays. The present study...
Chromosomal instability (CIN) is very frequent in gastroesophageal adenocarcinoma (GEA) and it characterized by TP53 deletions/mutations resulting p53 nuclear accumulation, as revealed immunohistochemistry (IHC), which considers the cases with “high” staining levels to be positive. Aiming improve aberrant detection, droplet digital PCR (ddPCR) was used evaluate deletion formalin-fixed, paraffin-embedded DNA (FFPE-DNA) cell-free (cfDNA). To further investigate mutational profile,...
Abstract Intrabdominal dissemination of malignant mesothelioma (MM) and pseudomyxoma peritonei (PMP) is poorly characterized with respect to the stemness window which cells activate during their reshaping on epithelial‐mesenchymal (E/M) axis. To gain insights into properties prognostic significance in these rarer forms peritoneal metastases (PM), primary tumor cultures from 55 patients selected for cytoreductive surgery hyperthermic intraperitoneal chemotherapy were analyzed cancer stem...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited survival. Curative opportunities are only available for patients resectable cancer. Palliative chemotherapy the current standard of care unresectable tumors. Numerous efforts have been made to investigate new therapeutic strategies PDAC. Immunotherapy has found be effective in treating tumors high microsatellite instability (MSI-H), including The ability Endoscopic Ultrasound Fine Needle Biopsy (EUS-FNB)...
<title>Abstract</title> Esophageal and esophagogastric junction adenocarcinoma (EADC-EGJA) prognosis is poor, Barrett’s esophagus has increased risk of developing tumor through the carcinogenesis process from metaplasia/low-grade dysplasia to high-grade (HGD). Long interspersed nuclear element-1 (LINE-1) considered a surrogate marker global methylation, an epigenetic event contributing progression. cfDNA 90 patients with never dysplastic (NDBE), HGD/early EADC-EGJA or locally...
<p>STR profile of the primary sarcoma cell lines.</p>
<p>Flow diagram according to REMARK guidelines.</p>
<p>Characterization of primary sarcoma cell lines.</p>
<p>Univariate Cox regression models for association between molecular markers and OS.</p>
<p>Kaplan-Meier curves for OS of STS patients the screening set.</p>
<p>Characteristics of the 67 STS patients analyzed for circulating levels periostin.</p>
<p>Characterization of primary sarcoma cell lines.</p>
<p>STR profile of the primary sarcoma cell lines.</p>
<p>Flow diagram according to REMARK guidelines.</p>
<p>Univariate and multiple Cox regression models for clinical predictors of OS.</p>
<p>Univariate Cox regression models for association between molecular markers and OS.</p>