A5107658269- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Dark Matter and Cosmic Phenomena
- Cosmology and Gravitation Theories
- Computational Physics and Python Applications
- Neutrino Physics Research
- Astrophysics and Cosmic Phenomena
- Black Holes and Theoretical Physics
- Medical Imaging Techniques and Applications
- Particle Accelerators and Free-Electron Lasers
- Distributed and Parallel Computing Systems
- Gamma-ray bursts and supernovae
- Nuclear reactor physics and engineering
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cell Adhesion Molecules Research
- Atomic and Subatomic Physics Research
- International Science and Diplomacy
- Radiation Detection and Scintillator Technologies
- Radiation Therapy and Dosimetry
- Scientific Computing and Data Management
- Genomic variations and chromosomal abnormalities
- Cancer and Skin Lesions
European Organization for Nuclear Research
2016-2025
University of Zurich
2020-2025
Institute of High Energy Physics
2015-2024
University of Antwerp
2024
A. Alikhanyan National Laboratory
2014-2024
National Central University
2023
University of Turin
2002-2019
University of Belgrade
2016
Vinča Institute of Nuclear Sciences
2009-2016
Instituto de Física de Cantabria
2015
The discovery by the ATLAS and CMS experiments of a new boson with mass around 125 GeV measured properties compatible those Standard-Model Higgs boson, coupled absence discoveries phenomena beyond Standard Model at TeV scale, has triggered interest in ideas for future factories. A circular e+e- collider hosted 80 to 100 km tunnel, TLEP, is among most attractive solutions proposed so far. It clean experimental environment, produces high luminosity top-quark, W Z studies, accommodates multiple...
Abstract Approximately 8% of breast cancers show increased copy numbers chromosome 17 centromere (CEP17) by fluorescence in situ hybridization (FISH) (ie average CEP17 >3.0 per nucleus). Currently, this pattern is believed to represent polysomy 17. HER2 ‐amplified have been shown harbour complex patterns genetic aberrations 17, particular involving its long arm. We hypothesized that aberrant FISH assays may not necessarily true polysomy. Eighteen randomly selected polysomic cases and a...
Power sector companies are crucial in global decarbonization, accounting for 32% of greenhouse gas emissions. Despite frameworks like the Science-Based Targets initiative (SBTi), there is ongoing debate about adequacy current target-setting methods and emissions allocation. This paper focuses on Brazil’s diverse, renewable-heavy energy mix complex regulatory environment. It highlights challenges faced by vertically integrated predominantly renewable meeting SBTi goals, despite their...
The MCF7 (ER+/HER2-), T47D BT474 (ER+/HER2+) and SKBR3 (ER-/HER2+) breast cancer cell lines are widely used in research as paradigms of the luminal HER2 phenotypes. Although they have been subjected to cytogenetic analysis, their chromosomal abnormalities not carefully characterized, differential profiles yet established. In addition, techniques such comparative genomic hybridization (CGH), microarray-based CGH multiplex ligation-dependent probe amplification (MLPA) described specific...
Abstract Background. The primary objectives of this study on carcinomas with equivocal HER2 expression were to assess the impact distinct recommendations regard identifying patients eligible for anti-HER2 agents by fluorescence in situ hybridization (FISH) and elucidate whether multiplex ligation-dependent probe amplification (MLPA) may be support assessing gene status. Methods. A cohort 957 immunohistochemistry-evaluated HER2-equivocal cases was analyzed dual-color FISH. results assessed...
Gastric cancer shows intratumoral heterogeneity for human epidermal growth factor receptor 2 expression. We evaluated whether the number of tissue blocks analyzed or antibodies used may influence immunohistochemical results in gastrectomy specimens. Clinicopathologic data from 148 patients receiving gastric surgery were collected. One block each 88 primary tumors and 60 paired metastases was examined status by immunohistochemistry using 3 different (HercepTest, CB11, 4B5) fluorescent situ...
Immunohistochemistry (IHC) and fluorescent-in situ hybridization (FISH) are standard methods to assess human epidermal growth factor receptor 2 (HER2) status in breast cancer (BC) patients. Real-time quantitative polymerase-chain-reaction (qRT-PCR) is able detect HER2 overexpression. Here we compared FISH, IHC, PCR (qPCR), qRT-PCR determine the concordance rates evaluate their relative roles determination. We determined 153 BC patients, using Q-PCR qRT-PCR. In discordant cases, directly...
Higher-grade meningiomas (WHO grade II and III) represent a diagnostic prognostic challenge. We assessed the pathological molecular characteristics of 94 higher-grade (85 II, 9 to identify novel parameters. Higher mitotic count (p = 0.018), diffuse (≥50%) prominent nucleoli < 0.001), sheeting 0.001) were associated with recurrence. Lower SSTR2a-positive cells median rate 0.048) TERT promoter mutations 0.014) recurrence patient death, respectively; further analyses did not other outcome...
Abstract Following axotomy, cerebellar Purkinje cells (PCs) do not elongate their axons, even in a favourable environment, and are resistant to death. They have no constitutive presence of common growth‐associated proteins, such as GAP‐43 c‐Jun Previous experiments show that injured transgenic PCs overexpressing exhibit profuse sprouting along the axon at its severed end. Nevertheless, lesioned axons unable regenerate either spontaneously or into growth‐permissive environments. In addition,...
On July 4, 2012, the discovery of a new boson, with mass around 125 GeV/c2 and properties compatible those standard-model Higgs was announced at CERN. In this context, high-luminosity electron-positron collider ring, operating in LHC tunnel centre-of-mass energy 240 GeV called LEP3, becomes an attractive opportunity both from financial scientific point views. The performance suitability CMS detector are evaluated, emphasis on accurate measurement boson properties. precision expected for...
The prospective analyses for the search of Standard Model (SM) Higgs boson decaying in to ZZ * → 4 leptons (4e, 4µ or 2e2µ) WW lνl ′ ν (l l' = e µ) with ATLAS and CMS detectors at CERN LHC pp collider are presented.Signal background datasets obtained a detailed Monte Carlo simulation response treated using complete reconstruction chain.An evaluation expected 95% C.L. exclusion limit early searches is presented.It showed that these two channels alone should allow excluding SM mass range...