A5100781187- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Statistical Methods in Clinical Trials
- PARP inhibition in cancer therapy
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
- BRCA gene mutations in cancer
- Pancreatic and Hepatic Oncology Research
- Pluripotent Stem Cells Research
- Histone Deacetylase Inhibitors Research
- Workplace Health and Well-being
- Gynecological conditions and treatments
- Cancer Treatment and Pharmacology
- Liver Disease Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Cancer Research and Treatments
- Gene expression and cancer classification
- Reproductive Health and Contraception
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic function and diabetes
- Vascular Malformations and Hemangiomas
- Drug-Induced Hepatotoxicity and Protection
- Dupuytren's Contracture and Treatments
- Cell Image Analysis Techniques
- Art Therapy and Mental Health
Jining Medical University
2025
Wenzhou Medical University
2024
Ruian People's Hospital
2024
Changchun University of Chinese Medicine
2021-2024
Chongqing University
2024
Second Affiliated Hospital of Zhejiang University
2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Bayer (United States)
2013-2022
People's Hospital of Bishan District
2022
ABSTRACT Hepatocyte-like cells (HLCs) are derived from human pluripotent stem (hPSCs) in vitro, but differentiation protocols commonly give rise to a heterogeneous mixture of cells. This variability confounds the evaluation vitro functional assays performed using HLCs. Increased efficiency and more accurate approximation vivo hepatocyte gene expression profile would improve utility hPSCs. Towards this goal, we demonstrate purification subpopulation HLCs surface marker asialoglycoprotein...
Abstract Survivin is an essential mitotic gene, and this has been speculated to reflect its primary function in development cancer. Here, we generated a knock-in transgenic mouse (SVVp-GFP) which green fluorescent protein (GFP) reporter gene was placed under the control of survivin promoter that regulates transcription at mitosis. The expression endogenous widespread tissues during shortly after birth. In contrast, GFP reactivity undetectable embryos, largely limited postnatally cells...
When analyzing time-to-event data in a non-parametric setting without considering covariates, the Kaplan-Meier estimator is widely used to estimate survival function. Cox proportional hazards model account for covariates effects. In this setting, baseline function, most commonly approach Breslow method, which estimates function as an exponential of cumulative hazard However, unnatural and undesirable feature that, its estimated probability will never reaches zero even if last observation...
In designing a clinical trial for comparing two or more treatments with respect to overall survival (OS), proportional hazards assumption is commonly made. However, in many cancer trials, patients pass through various disease states prior death and because of this may receive other than originally assigned. For example, crossover from the control treatment experimental at progression. Even without crossover, pattern after progression be very different The will not hold these situations...
Clinical trials in the era of precision cancer medicine aim to identify and validate biomarker signatures which can guide assignment individually optimal treatments patients. In this article, we propose a group sequential randomized phase II design, updates signature as trial goes on, utilizes enrichment strategies for patient selection, uses Bayesian response-adaptive randomization treatment assignment. To evaluate performance new addition commonly considered criteria type I error power,...
Severe fever with thrombocytopenia syndrome (SFTS), which is caused by a novel Bunyavirus, has gradually become threatening infectious disease in rural areas of Asia. Studies have identified severe cytokine storm and impaired humoral immune response SFTS. However, the cellular to SFTS virus (SFTSV) infection remains largely unknown. Here we report that patients had accompanied high levels chemokines. CD8+ T cells peripheral blood mononuclear exhibited more activated phenotype enhanced...
Limited research has examined the factors associated with female permanent contraception procedures. This study evaluated temporal trend in use of hysteroscopic sterilization (HS) vs laparoscopic (LS) and characteristics commercially insured Medicaid-insured women US who have had procedures.Women aged 15-49 years claims for HS LS procedures were identified from two MarketScan databases, one consisting commercial other Medicaid claims, during time period January 1, 2003 to December 31, 2012...
As a high-value bulk chemical, ethylene glycol plays an important role in many fields such as energy, the chemical industry, and automobile manufacturing. At same time, methanol, economical efficient raw material, has shown great potential promoting innovation of bio-based chemicals fuels. In view this, this study focused on excavation innovative application enzymes, successfully designed artificial cascade catalytic system. The system cleverly converts methanol into glycol, core is composed...
A bronchogenic cyst (BC) is a rare congenital lesion that may cause life-threatening organ compression in children, but generally asymptomatic adults unless there are other complications. In the present report, 34-year-old woman whom BC was complicated by tuberculosis infection described. Due to small size of BC, it and could not be diagnosed until she treated with antituberculosis medications.
Introduction: Nail stem cell (NSC) differentiation plays a vital role in maintaining nail homeostasis and facilitating digit regeneration. Recently, onychofibroblasts (OFs), specialized mesenchymal cells beneath the matrix, have emerged as potential regulators of NSC differentiation. However, limited understanding OFs’ cellular properties transcriptomic profiles hinders our comprehension their role. This study aims to characterize human OFs investigate involvement Methods: Human were...