A5017151176- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Congenital Heart Disease Studies
- Central Venous Catheters and Hemodialysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Takotsubo Cardiomyopathy and Associated Phenomena
- Coronary Artery Anomalies
- Vascular anomalies and interventions
- Cardiovascular Syncope and Autonomic Disorders
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- COVID-19 and healthcare impacts
- Renal and Vascular Pathologies
- Vascular Procedures and Complications
- Lipoproteins and Cardiovascular Health
- COVID-19 Clinical Research Studies
Tehran University of Medical Sciences
2015-2025
Tehran Heart Center
2017-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2022-2023
Newcastle University
2022-2023
Freeman Hospital
2022-2023
University of Tehran
2007-2021
Shahid Beheshti University of Medical Sciences
2017
Imam Khomeini Hospital
2007
The optimal treatment of intermediate-high-risk pulmonary embolism (PE) remains unknown.To assess the effect conventional catheter-directed thrombolysis (cCDT) plus anticoagulation vs monotherapy in improving echocardiographic measures right ventricle (RV) to left (LV) ratio acute PE.The Catheter-Directed Thrombolysis Anticoagulation Patients with Acute Intermediate-High-Risk Pulmonary Embolism (CANARY) trial was an open-label, randomized clinical patients PE, conducted 2 large...
Abstract Background Acute kidney injury (AKI) is one of the preventable complications percutaneous coronary intervention (PCI). This study aimed to develop machine learning (ML) models predict AKI after PCI in patients with acute syndrome (ACS). Methods was conducted at Tehran Heart Center from 2015 2020. Several variables were used design five ML models: Naïve Bayes (NB), Logistic Regression (LR), CatBoost (CB), Multi-layer Perception (MLP), and Random Forest (RF). Feature importance...
Acute myocardial infarction (AMI) remains a leading global cause of mortality. This study explores predictors in-hospital mortality among AMI patients using advanced machine learning (ML) techniques. Data from 7422 treated with percutaneous coronary intervention (PCI) at Tehran Heart Center (2015-2021) were analyzed. Fifty-eight clinical, demographic, and laboratory variables evaluated. Seven ML algorithms, including Random Forest (RF), logistic regression LASSO, XGBoost, implemented. The...
Ischemia following acute myocardial infarction (AMI) increases the level of pro-fibrotic and inflammatory cytokines, including transforming growth factor (TGF)-β tumor necrosis (TNF)-α. N-acetylcysteine (NAC) has therapeutic benefits in management patients with AMI. To best our knowledge, this is first study that evaluated effect NAC on TNF-α TGF-β levels Following confirmation AMI, 88 were randomly administered 600 mg (Fluimucil®, Zambon, Ticino, Switzerland) or placebo orally twice daily...
We aimed to demonstrate the clinical utility of CHA2DS2-VASc score in risk assessment patients with STEMI regarding adverse outcomes particularly no-reflow phenomenon. designed a retrospective cohort study using data Tehran Heart Center registry for acute coronary syndrome. The included 1331 consecutive who underwent primary angioplasty. Patients were divided into two groups according low and high score. Angiographic results reperfusion inspected evaluate association likelihood suboptimal...
Identification of pulmonary thromboembolism (PTE), as a cause syncope, is important and may be life saving. We prospectively analyzed data on 335 patients with acute PTE. Relationships between syncope secondary to PTE clinical findings, risk factors, imaging modalities were analyzed. Of the patients, 36 (10.7%) had at presentation. Compared without those higher frequency right ventricular (RV) dysfunction (94.3% vs 72.1%, respectively; P value = .004) saddle embolism (24.2% 10.9%, .044)....
Pulmonary thromboembolism (PE) is the third leading cause of cardiovascular events. The conventional modeling methods and severity risk scores lack multiple laboratories, paraclinical imaging data. Data science machine learning (ML) based prediction models may help better predict outcomes.In this retrospective registry-based design, all consecutive hospitalized patients diagnosed with pulmonary (based on CT angiography) from 2011 to 2019 were recruited. ML algorithms [Gradient Boosting (GB)...
Abstract Background Acute ST‐elevation myocardial infarction (STEMI) is a leading cause of mortality and morbidity worldwide, primary percutaneous coronary intervention (PCI) the preferred treatment option. Hypothesis Machine learning (ML) models have potential to predict adverse clinical outcomes in STEMI patients treated with PCI. However, comparative performance different ML for this purpose unclear. Methods This study used retrospective registry‐based design recruit consecutive...
High-intensity interval training (HIIT) appears to be safe and effective in cardiovascular diseases. However, there is a paucity of data on the effect HIIT for patients with acute pulmonary embolism (PE). The present randomized controlled trial (RCT) therefore examined efficiency safety PE.In single-center parallel open-label RCT, 24 (5 women) discharged recently diagnosis intermediate-high-risk PE were (1:1) supervised (n = 12) or control group. primary outcomes exercise capacity evaluated...
Abstract: Primary percutaneous coronary intervention (PPCI) is the gold standard of treatment in patients with acute ST-elevation myocardial infarction (STEMI). The no-reflow phenomenon (NRP) a detrimental consequence STEMI. Colchicine an anti-inflammatory drug that may help prevent NRP and improve patient outcomes. In randomized, double-blind, placebo-controlled clinical trial, 451 STEMI who were candidates for PPCI eligible enrollment randomized into colchicine group (n = 229) control...
The value of urinary albumin excretion in the prediction myocardial ischemia men and women with type 2 diabetes is not well understood. We questioned whether gender influences albuminuria-ischemic heart disease relationship patients diabetes.We designed a matched case-control study 926 albuminuria (cases) age body mass index without (controls). Ischemic was defined as presence (1) history angina pectoris or equivalent symptoms critical care unit admission, (2) infarction and/or...
We studied the predictors and patterns of high-sensitivity cardiac troponin T (hs-cTnT) elevation in patients with paroxysmal supraventricular tachycardia (PSVT) presence absence ischemic heart disease. During calendar year 2013, we enrolled 70 72 consecutive adult PSVT who presented at our center within 4 hours after onset tachycardia. On basis increased hs-cTnT either 2 initial measurements, divided into groups (hs-cTnT-positive hs-cTnT-negative), to study enzyme elevation. then...
We compare the early and midterm outcomes of pulmonary thromboembolism (PTE) in patients with without syncope our single-center registry.Between December 2006 May 2013, 351 consecutive (mean age = 60.21 ± 16.91 years, 55.3% male) confirmed acute symptomatic PTE were divided groups. Groups compared terms effect on 30-day mortality adverse events, a median follow-up time 16.9 months.From patients, 39 (11.1%) had 312 (88.9%) did not. Syncope group less frequently chest pain (30.8% vs 51.4%; P...
Abstract Background Considerable number of people still use opium worldwide and many believe in opium’s health benefits. However, several studies proved the detrimental effects on body, especially cardiovascular system. Herein, we aimed to provide first evidence regarding one-year major adverse events (MACE) patients with ST-elevation MI (STEMI) who underwent primary PCI. Methods We performed a propensity score matching 2:1 (controls: users) that yielded 518 users 1036 controls. Then,...