A5064544089- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Molecular Biology Techniques and Applications
- Pluripotent Stem Cells Research
- Neurotransmitter Receptor Influence on Behavior
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Renal and related cancers
- Sperm and Testicular Function
- Hormonal Regulation and Hypertension
- Gene expression and cancer classification
- CRISPR and Genetic Engineering
- Cannabis and Cannabinoid Research
- Adrenal and Paraganglionic Tumors
- Neuroscience and Neural Engineering
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
Ludwig-Maximilians-Universität München
2022-2025
LMU Klinikum
2022-2024
Helmholtz Zentrum München
2022-2024
Max Planck Institute for Biological Intelligence
2024
Urologische Klinik München
2024
Institute of Bioinformatics and Systems Biology
2022
University of Patras
2018
Traumatic brain injury leads to a highly orchestrated immune- and glial cell response partially responsible for long-lasting disability the development of secondary neurodegenerative diseases. A holistic understanding mechanisms controlling responses specific types their crosstalk is required develop an efficient strategy better regeneration. Here, we combine spatial single-cell transcriptomics chart transcriptomic signature injured male murine cerebral cortex, identify states different...
Abstract Spatially resolved transcriptomics has revolutionized RNA studies by aligning abundance with tissue structure, enabling direct comparisons between histology and gene expression. Traditional approaches to identifying signature genes often involve preliminary data grouping, which can overlook subtle expression patterns in complex tissues. We present Spatial Gradient Screening, an algorithm facilitates the supervised detection of histology-associated without prior grouping. Utilizing...
Abstract Astrocyte heterogeneity has been well explored, but our understanding of white matter (WM) astrocytes and their distinctions from gray (GM) remains limited. Here, we compared cortical GM WM/corpus callosum (WM/CC) using single-cell RNA sequencing spatial transcriptomics the murine forebrain. The comparison revealed similarities also significant differences between WM astrocytes, including cytoskeletal metabolic hallmarks specific to with molecular properties shared human astrocytes....
Primary aldosteronism is frequently caused by an adrenocortical aldosterone-producing adenoma (APA) carrying a somatic mutation that drives aldosterone overproduction. APAs with in KCNJ5 (APA-KCNJ5MUT) are characterized heterogeneous CYP11B2 (aldosterone synthase) expression, particular cellular composition and larger tumor diameter than those wild-type (APA-KCNJ5WT). We exploited these differences to decipher the roles of transcriptome metabolome reprogramming pathogenesis. Consecutive...
Neonatal handling is an experimental model of early life experience associated with resilience in later challenges, altering the ability animals to respond stress. The endocannabinoid system brain modulates neuroendocrine and behavioral effects stress, while this also capable being modulated by stress exposure itself. present study has addressed question whether neonatal rats could affect cannabinoid receptors, age- sex-dependent manner, using
The oligodendrocyte progenitors (OPCs) are at the front of glial reaction to traumatic brain injury. However, regulatory pathways steering OPC as well role reactive OPCs remain largely unknown. Here, we compared a long-lasting, exacerbated adult zebrafish injury with timely restricted activation identify specific molecular mechanisms regulating reactivity and their contribution regeneration. We demonstrated that influx cerebrospinal fluid into parenchyma after simultaneously activates...
Peritubular cells of the human testis form a small compartment surrounding seminiferous tubules. They are crucial for sperm transport, and they emerge as contributors to spermatogonial stem cell niche. among least known types body. We employed single-cell RNA sequencing cultured testicular peritubular (HTPCs), which had been isolated from samples donors with normal spermatogenesis. The significant overlap between our results recently published ex vivo data indicates that HTPCs highly...
Abstract Astrocytes exhibit dual roles in central nervous system (CNS) recovery, offering both beneficial and detrimental effects. Following CNS injury, a subset of astrocytes undergoes proliferation, de-differentiation, acquires self-renewal neurosphere-forming capabilities vitro. This represents promising target for initiating brain repair processes holds potential neural recovery. However, studying these rare plastic is challenging due to the absence distinct markers. In our study, we...
ABSTRACT Astrocytes play key roles in brain function, but how these are orchestrated by transcription factors (TFs) the adult and aligned with astrocyte heterogeneity is largely unknown. Here we examined localization function of novel TF Trps1 (Transcriptional Repressor GATA Binding 1) well‐known Sox9 Cas9‐mediated deletion using Mokola‐pseudotyped lentiviral delivery into cerebral cortex. levels showed among cortical astrocytes, which prompted us to explore effects deleting either or alone...
Abstract Traumatic brain injury leads to a highly orchestrated immune- and glial cell response partially responsible for long-lasting disability the development of secondary neurodegenerative diseases. A holistic understanding mechanisms controlling responses specific types their crosstalk is required develop an efficient strategy better regeneration. Here, we combined spatial single-cell transcriptomics chart transcriptomic signature injured murine cerebral cortex, identified states...