A5000817632- Neuroinflammation and Neurodegeneration Mechanisms
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Conducting polymers and applications
- Enzyme Structure and Function
- Neuroscience of respiration and sleep
- Surgical Sutures and Adhesives
- Cell Image Analysis Techniques
- Pluripotent Stem Cells Research
- Bacterial Genetics and Biotechnology
- DNA and Nucleic Acid Chemistry
- Optical Polarization and Ellipsometry
- Medicinal Plants and Neuroprotection
- RNA Interference and Gene Delivery
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Spectroscopy Techniques in Biomedical and Chemical Research
Ludwig-Maximilians-Universität München
2022-2025
Urologische Klinik München
2024
Helmholtz Zentrum München
2023
LMU Klinikum
2022
Institute of Bioinformatics and Systems Biology
2022
Université de Bordeaux
2018
Universität Innsbruck
2013-2015
University of Vienna
1999
Traumatic brain injury leads to a highly orchestrated immune- and glial cell response partially responsible for long-lasting disability the development of secondary neurodegenerative diseases. A holistic understanding mechanisms controlling responses specific types their crosstalk is required develop an efficient strategy better regeneration. Here, we combine spatial single-cell transcriptomics chart transcriptomic signature injured male murine cerebral cortex, identify states different...
Significance The three-dimensional fold and inherent structural dynamics of RNA are critical determinants function. Although the hierarchical folding secondary structure followed by tertiary formation is well established, insights into how units impact remain elusive. Using single-molecule FRET imaging preQ 1 class II bacterial riboswitch, we reveal that employs stem–loop insertions classical pseudoknots as a tool to tune ligand response hence outcome natural gene-regulatory elements.
Neural circuit responses arise from computations across diverse synapses within a neuron, making synaptic integration crucial parameter to restore function after injury. Neuron transplantation offers promising approach for restoration injury, but our knowledge of transplanted neuron (tN) connectivity remains limited. Here, we used stab wound injury model, examine how tNs mature and integrate using multimodal read-outs. We analyzed the morphological, ultrastructural functional aspects tN...
<h3>Abstract</h3> In central respiratory circuitry, synaptic excitation is responsible for synchronizing neuronal activity in the different rhythm phases, whereas chloride-mediated inhibition important shaping pattern itself. The potassium chloride cotransporter KCC2, which serves to maintain low intraneuronal Cl<sup>–</sup> concentration and thus render signaling inhibitory, exists two isoforms, KCC2a KCC2b. KCC2 essential functional breathing motor control at birth, but specific...
Abstract The 2′‐trifluoromethylthio (2′‐SCF 3 ) modification endows ribonucleic acids with exceptional properties and has attracted considerable interest as a reporter group for NMR spectroscopic applications. However, only modified pyrimidine nucleosides have been generated so far. Here, the syntheses of 2′‐SCF adenosine guanosine phosphoramidites which latter was obtained in highly efficient manner by an unconventional Boc‐protecting strategy, are reported. RNA solid‐phase synthesis...
The oligodendrocyte progenitors (OPCs) are at the front of glial reaction to traumatic brain injury. However, regulatory pathways steering OPC as well role reactive OPCs remain largely unknown. Here, we compared a long-lasting, exacerbated adult zebrafish injury with timely restricted activation identify specific molecular mechanisms regulating reactivity and their contribution regeneration. We demonstrated that influx cerebrospinal fluid into parenchyma after simultaneously activates...
Abstract Traumatic brain injury leads to a highly orchestrated immune- and glial cell response partially responsible for long-lasting disability the development of secondary neurodegenerative diseases. A holistic understanding mechanisms controlling responses specific types their crosstalk is required develop an efficient strategy better regeneration. Here, we combined spatial single-cell transcriptomics chart transcriptomic signature injured murine cerebral cortex, identified states...
Abstract Background Direct conversion of reactive glial cells to neurons is a promising avenue for neuronal replacement therapies after brain injury or neurodegeneration. The overexpression neurogenic fate determinants in results neurons. For repair purposes, the should ideally be induced pathology-induced neuroinflammatory environment. However, very little known regarding influence injury-induced environment and released growth factors on direct process. Results We established new vitro...