A5064854485- Schizophrenia research and treatment
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Psychology of Moral and Emotional Judgment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Neuroscience and Music Perception
- COVID-19 and Mental Health
- Emotions and Moral Behavior
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Mental Health Treatment and Access
- Ethics in Business and Education
- Optimism, Hope, and Well-being
- Misinformation and Its Impacts
- Neuroendocrine regulation and behavior
- Social and Intergroup Psychology
- CO2 Sequestration and Geologic Interactions
- Electroconvulsive Therapy Studies
- Material Selection and Properties
- Olfactory and Sensory Function Studies
- Epistemology, Ethics, and Metaphysics
- Mental Health and Psychiatry
- Management of metastatic bone disease
- Sleep and related disorders
Stony Brook University
2018-2024
Icahn School of Medicine at Mount Sinai
2017-2020
Max Planck Institute for Human Development
2018
Medical University of South Carolina
2018
Instituto de Neurología Cognitiva
2018
Harvard University
2018
University of Washington
1991-2006
Dana-Farber Cancer Institute
1990
The COVID-19 global pandemic has left many feeling a sense of profound uncertainty about their world, safety, and livelihood. Sources espousing misinformation conspiracy theories frequently offer information that can help make this uncertainty. Individuals high in intolerance (IU) may be particularly impacted by the impoverished epistemic environment thus more drawn to conspiratorial thinking (CT). In present work, we show across 2 studies (
Background Our previous work revealed substantial heterogeneity in the cognitive profile of bipolar disorder (BD) due to presence three underlying subgroups characterized as: globally impaired, selectively or cognitively intact. In an effort determine whether these are differentially related genetic risk for illness, we investigated deficits were more pronounced unaffected siblings (UAS) BD probands within identified clusters. Methods Cluster analysis was used identify clusters ( N = 60)....
According to the justified true belief (JTB) account of knowledge, people can truly know something only if they have a that is both and (i.e., knowledge JTB). This was challenged by Gettier, who argued JTB does not explain attributions in certain situations, later called “Gettier-type cases,” wherein protagonists are believing be true, but their correct because luck. Laypeople may attribute with luckily beliefs. Although some research has found evidence for these so-called Gettier...
The novel coronavirus COVID-19 pandemic is associated with elevated rates of anxiety and relatively lower compliance public health guidelines in younger adults. To develop strategies for reducing increasing adherence guidelines, it important to understand the factors that contribute context COVID-19. Earlier research has shown greater perceived risk negative events their costs are increased behaviors, but unclear what role they play a surrounded by uncertainty. In present study we measured...
The COVID-19 global pandemic has left many feeling a sense of profound uncertainty about their world, safety, and livelihood. Information that can help make this is offered by both official health-organizations as well sources espousing misinformation conspiracy theories. Individuals high in intolerance (IU) may be particularly impacted the impoverished epistemic environment thus more drawn to conspiratorial thinking (CT). In present study we show endorsement COVID-19-specific theories...
Mismatch negativity (MMN) amplitude is reduced in psychotic disorders and associated with symptoms functioning. Due to these robust associations, it often considered a biomarker for illness. The relationship between MMN clinical outcomes has been examined well early onset illness; however, its stability predictive utility chronic samples are not clear.
Abstract Uncertainty has been a central concept in psychological theories of anxiety. However, this plagued by divergent connotations and operationalizations. The lack consensus hinders the current search for cognitive biological mechanisms anxiety, jeopardizes theory creation comparison, restrains translation basic research into improved diagnoses interventions. Drawing upon uncertainty decomposition Bayesian Decision Theory, we propose well‐defined conceptual structure clinical sciences,...
Despite advances in the treatment of bipolar disorder (BD), most patients do not achieve complete inter-episode recovery and functional disability is common. During periods relative remission, many continue to experience neurocognitive dysfunction, reduced daytime activity levels, sleep disturbances. This 8-week, randomized, placebo-controlled pilot study evaluated feasibility, safety preliminary efficacy wake-promoting drug, modafinil (Provigil®), on functioning, sleepiness, quality...
Abstract Background: Verbal memory (VM) impairment is prominent in bipolar disorder (BD) and linked to functional outcomes. However, the intricacies of VM have not yet been studied a large sample BD patients. Moreover, some proposed deficits that may be mediated by organizational strategies, such as semantic or serial clustering. Thus, exact nature break-down patients well understood, limiting remediation efforts. We investigated versus healthy controls (HCs) examined whether verbal learning...
According to the Justified True Belief account of knowledge (JTB), a person can only truly know something if they have belief that is both justified and true (i.e., belief). This was challenged by Gettier (1963), who argued JTB does not explain attributions in certain situations, later called Gettier-type cases, wherein protagonist believing be but their correct due luck. Lay people may attribute protagonists with luckily beliefs. While some research has found evidence for these so-called...
Cognitive impairment is a prominent and difficult to treat symptom in schizophrenia (SZ), which directly related functional disability. A variant the gene coding for alpha 1C subunit of L-type voltage gated calcium channel (CACNA1C) has been shown negatively affect several neurocognitive domains. We conducted 4-week, open label, pilot study isradipine, blocker, determine its feasibility, safety, efficacy improving cognition SZ patients. Ten adults with stable were started on flexible dose...
Recent work has shown that emotional arousal influences decision-making in sacrificial moral dilemmas, with heightened levels of associated increased aversion to committing transgressions maximize utilitarian outcomes. Patients anxiety disorders experience pathologically states and thus may be expected exhibit reduced responding on such dilemmas. Extant evidence been mixed, however, regarding whether anxious patients differ their decisions from controls, no study conducted a careful...
Abstract Background Life events (LEs) are a risk factor for first onset and relapse of psychotic disorders. However, the impact LEs on specific symptoms – namely reality distortion, disorganization, negative symptoms, depression, mania remains unclear. Moreover, differential effects v. positive poorly understood. Methods The present study utilizes an epidemiologic cohort patients ( N = 428) ascertained at first-admission psychosis followed decade thereafter. Symptoms were assessed 6-, 24-,...
Self-stigma has been associated with reduced accuracy of face emotion recognition in individuals at clinical high risk for psychosis (CHR). Stigma may also relate to slowing performance during cognitive tasks which a negative stereotype is relevant. This study aimed investigate the association mental illness stigma among CHR individuals. Participants were 143 identified using Structured Interview Psychosis-Risk Syndromes (SIPS). Face was assessed Penn Emotion Recognition Task (ER-40)....
Anomalous beliefs exist on a continuum ranging from conventional to delusions. Recent work proposes that delusions may be formed via acquiescence, in which intuitive arise and persist despite awareness they conflict with rationality. Cognitive control theory can similarly explain how we fail detect delusional rationality, and/or marshal cognitive (analytic) resources override them. We measured processes using decision-making task analytic Stroop reflection (CRT) tasks. Stronger intuition...
Background: Mismatch negativity (MMN) is reduced in psychotic disorders and associated with symptoms functioning. Several studies have posited the MMN as an index of prediction error (PE), a neural signal theorized to give rise deficits illness. This mechanism has been examined well early onset illness; however, its stability predictive utility chronic samples are not clear. Method: We five-year amplitude individuals established (cases; N=132) never-psychotic participants (NP; N=170),...
Hallucinations are characterized by disturbances in perceptual decision-making about environmental stimuli. When integrating across multiple stimuli to form a decision, typical observers engage "robust averaging" down-weighting extreme evidence, akin statistician excluding outlying data. Furthermore, adapt contexts with more unreliable evidence increasing this strategy. Here, we test the hypothesis that hallucination-prone individuals (n = 38 high vs n 91 low) would show decrease robust...