A5057253736- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- LGBTQ Health, Identity, and Policy
- Sex work and related issues
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- SARS-CoV-2 detection and testing
- HIV/AIDS oral health manifestations
- Syphilis Diagnosis and Treatment
- Bacillus and Francisella bacterial research
- Reproductive tract infections research
- Global Maternal and Child Health
- Vaccine Coverage and Hesitancy
- Artificial Intelligence in Healthcare
- Immune Cell Function and Interaction
- Ethics in Clinical Research
- Bipolar Disorder and Treatment
- Family Caregiving in Mental Illness
- Mental Health and Patient Involvement
- Liver Disease Diagnosis and Treatment
Aaron Diamond AIDS Research Center
2016-2025
Columbia University
2020-2025
Columbia University Irving Medical Center
2023-2025
Rockefeller University
2009-2020
Abstract SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 have surged notably to become dominant in the United States South Africa, respectively 1,2 . These new carrying further mutations their spike proteins raise concerns that they may evade neutralizing antibodies, thereby compromising efficacy of COVID-19 vaccines therapeutic monoclonals. We now report findings from a systematic antigenic analysis these surging subvariants. is only modestly (1.8-fold) more resistant sera vaccinated...
Objective In the context of continued high rates condomless anal intercourse and HIV-1 infection, young men who have sex with (YMSM) need additional effective desirable HIV prevention tools. This study reports on willingness a racially-ethnically diverse cohort YMSM to use new biomedical approach, long-acting injectable pre-exposure prophylaxis (LAI-PrEP) agent. Methods A cross-sectional conducted between June-August 2013 recruited participants from an ongoing in NYC. Participants included...
This study evaluated the prevalence and factors associated with sleep disturbance in a large cohort of HIV-infected patients across China. A cross-sectional was conducted among on antiretroviral therapy at 20 AIDS clinics. The Pittsburgh Sleep Quality Index self-administered by subjects. Socio-demographic characteristics, medical history HIV-related clinical data were collected. 4103 had complete for analysis. disturbances observed 43.1% patients. Associated multivariable analysis included...
Abstract SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 have surged dramatically to become dominant in the United States South Africa, respectively 1,2 . These novel carrying additional mutations their spike proteins raise concerns that they may further evade neutralizing antibodies, thereby compromising efficacy of COVID-19 vaccines therapeutic monoclonals. We now report findings from a systematic antigenic analysis these surging subvariants. is only modestly (1.8-fold) more resistant...
Approval of the first long-acting injectable antiretroviral therapy (LAI ART) medication heralded a new era HIV treatment. However, years since approval have been marked by implementation challenges. The "Accelerating Implementation Multilevel Strategies to Advance Long-Acting Injectable for Underserved Populations (ALAI UP Project)" aims accelerate systematic and equitable delivery LAI ART.
Abstract Background Columbia University Irving Medical Center (CUIMC) in New York City, collaboration with the Division of Infectious Diseases and Dental School, is addressing a critical gap HIV testing to support strategy End Epidemic (EHE). This emphasizes increasing rates providing patients information about pre-exposure prophylaxis (PrEP). Objectives study aimed achieve two key objectives: (1) develop robust clinical decision system (CDSS) capable identifying who stand benefit from (2)...
Background Phase III trials of long-acting injectable (LAI) PrEP, currently underway, have great potential for expanding the menu HIV prevention options. Imagining a future in which multiple PrEP modalities are available to users biomedical prevention, we investigated factors might help direct patient-physician shared-decision making process optimize choice method. Methods Participants (n = 105; ages 19–63; 46.7% men color) were former participants demonstration project and had taken daily...
Purpose: China recently commenced several pre-exposure prophylaxis (PrEP) projects, but little work has characterized potential users. This study describes awareness of, intention to use, and uptake of PrEP in a sample men who have sex with (MSM), key population experiencing high rates HIV China. Methods: Through cross-sectional survey administered 708 MSM four cities, we mapped respondents onto Motivational Cascade. We conducted bivariable multivariable analysis examine factors associated...
Despite abundant evidence on its safety, tolerability and cost-effectiveness, post-exposure prophylaxis (PEP) has not been officially approved for non-occupational use in China. This study aims to assess awareness of, willingness use, actual experience with PEP gay, bisexual other men who have sex (GBM) China explore potential associations between demographic, behavioral, psychosocial factors PEP-related outcomes. We recruited a convenience sample through community venue-based strategies,...
We investigated transmission of human immunodeficiency virus type 1 (HIV-1) via breast-feeding by 104 Chinese mothers who acquired the infection through blood transfusion postnatally. Of 106 children, 38 (35.8%) were infected. All children survived to age 5 years, and their survival curve was similar that mothers. These findings suggest a high rate HIV-1 when infected postnatally transfusion, perhaps because higher viremia expected during acute phase infection. The course disease among...
Abstract We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases (8.4%). 3,625 enrollees who were enrollment completed least one follow-up interview, 440 follow up period: this constituted an incidence rate 7.1 per 100 person-years (95% CI: 6.4–7.7). Early treatment...
Background: Anxiety and depression continue to be significant comorbidities for people with HIV infection. We investigated the prevalence of factors associated anxiety among adult HIV-infected patients across China. Methods: In this cross-sectional study, we described clinical psychosocial variables related in 4103 persons. Doctors assessed by asking whether they had experienced or prior month. Patients also self-administered Hospital Depression (HAD) scale; those score ≥8 on HAD-A/D were...
The timing, intensity and duration of the cytokine cascade reorganized interrelations in networks are not fully understood during acute HIV-1 infection (AHI). Using sequential plasma samples collected over three years post-infection a cohort MSM seroconvertors, we determined early kinetics levels FiebigI-IV stages using Luminex-based multiplex assays. Cytokines were quantified relationships between cytokines assessed by Spearman correlation. Compared with HIV-negative MSM, HIV-infected...
Objective To identify factors associated with mother-to-child-transmission and late access to prevention of maternal child transmission (PMTCT) services among HIV-infected women; risk for infant mortality HIV-exposed infants in order assess the feasibility virtual elimination vertical pediatric HIV this setting. Design Observational study evaluating impact a provincial PMTCT program. Methods The intervention was implemented 26 counties Yunnan Province, China at municipal tertiary health care...
Uptake of and persistence on pre-exposure prophylaxis (PrEP) in the United States have been limited. The potential new PrEP modalities to increase access will be hindered if underlying structural interpersonal barriers—including, insurance coverage, initiation maintenance clinical protocols, provider bias, stigma, lack trust health care—are not adequately addressed. We conducted in-person telephone-based recorded interviews with 32 US-based nonclinical providers spanning implementation...
Introduction Some African countries plan to introduce and scale-up new long-acting pre-exposure prophylaxis methods (LA-PrEP), like the monthly dapivirine vaginal ring (PrEP ring) injectable cabotegravir. National costed implementation plans, roadmaps for successful product implementation, are often overlooked. International stakeholders engaged in oral PrEP planning, introduction an information resource of lessons learned advise LA-PrEP planning. We consulted such international synthesised...