A5074225322- Intraperitoneal and Appendiceal Malignancies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Ovarian cancer diagnosis and treatment
- Tissue Engineering and Regenerative Medicine
- Appendicitis Diagnosis and Management
- Neonatal Respiratory Health Research
- Pleural and Pulmonary Diseases
- Connective tissue disorders research
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Cancer Cells and Metastasis
- Hemostasis and retained surgical items
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Multiple and Secondary Primary Cancers
- Inhalation and Respiratory Drug Delivery
- Diversity and Career in Medicine
- Oral and gingival health research
- Myasthenia Gravis and Thymoma
American Academy of Otolaryngology — Head and Neck Surgery
2025
Atrium Health Wake Forest Baptist
2021-2024
Oregon Health & Science University
2024
OHSU Knight Cancer Institute
2024
Cheung Kong Graduate School of Business
2023
University of Hong Kong
2023
Yale University
2023
Louisiana State University
2023
University of California, San Francisco
2023
Gilead Sciences (France)
2023
Bioadhesives are biopolymers with potential applications in wound healing, drug delivery, and tissue engineering. Pectin, a plant-based heteropolysaccharide, has recently demonstrated as mucoadhesive the gut. Since mucoadhesion is process likely involving interpenetration of pectin polymer mucin chains, we hypothesized that may also be effective at targeting glycocalyx visceral mesothelium. To explore role mesothelial bioadhesive, studied interaction various formulations mesothelium lung,...
Resection of colorectal liver metastasis (CLM) is beneficial when feasible. However, the benefit second hepatectomy for hepatic recurrence in CLM remains unclear.The Colorectal Liver Operative Metastasis International Collaborative retrospectively examined 1004 cases from 2000 to 2018 a total 953 patients. Hepatic after initial was identified 218 Kaplan-Meier analysis performed overall survival (OS) and recurrence-free (RFS). Propensity score matching (PSM) offset selection bias. Cox...
ABSTRACT Objective Health policies affect clinical practice and outcomes, serving as an impetus for civic engagement. Voting participation among Otolaryngology–Head Neck Surgery (OHNS) trainees is poorly characterized may be afflicted by distinct barriers specific to training. This the first study evaluate voter OHNS trainees. Methods We analyzed survey data from 2020 American Academy of Otolaryngology Section Residents Fellows (AAO SRF), capturing voting practices well attitudes promoting...
Abstract Objective Little is known about emotional intelligence (EI) among otolaryngology trainees and its assessment during training. We aim to assess EI levels identify demographic training‐related factors associated with higher EI. Study Design Cross‐sectional study. Setting Survey of trainees. Methods Residents fellows completed a national single‐response survey from the Governing Council Section for Fellows‐in‐Training (November 7 December 31, 2018). The Trait Emotional Intelligence...
The axial connective tissue system is a fiber continuum of the lung that maintains alveolar surface area during changes in volume. Although molecular anatomy remains undefined, central to contemporary models micromechanics and regeneration. To provide detailed structure system, we examined extracellular matrix murine lungs. lungs were decellularized using 24 hr detergent treatment protocol. Systematic evaluation demonstrated no residual cellular debris; morphometry mean 39 ± 7% reduction...
Healthy human skin tissue is often used as a control for comparison to diseased in patients with pathologies, including cancers or other inflammatory conditions such atopic dermatitis psoriasis. Although non-affected from these more appropriate choice comparison, there paucity of studies examining tissue. This lack exacerbated by the difficulty processing experimental analysis. In addition, choosing protocol which preserves cell viability and identity while sufficiently dissociating cells...
Pleural injury and associated air leaks are a major influence on patient morbidity healthcare costs after lung surgery. Pectin, plant-derived heteropolysaccharide, has recently demonstrated potential as an adhesive binding to the glycocalyx of visceral mesothelium. Since bioadhesion is process likely involving interpenetration pectin-based polymer with glycocalyx, we predicted that may also be effective sealant for pleural injury. To explore role equal (weight%) mixture high-methoxyl pectin...
Abstract Pulmonary “air leaks,” typically the result of pleural injury caused by lung surgery or chest trauma, in accumulation air space (pneumothorax). Air leaks are a major source morbidity and prolonged hospitalization after pulmonary surgery. Previous work has demonstrated structural heteropolysaccharide (pectin) binding to mouse glycocalyx. The similar lectin‐binding characteristics ultrastructural features human glycocalyx suggested potential application these polymers humans. To...
In patients with primary hyperparathyroidism (PHPT), bilateral neck exploration is necessary for multigland disease (MGD), whereas minimally invasive parathyroidectomy often preferred single-gland (SGD). An existing system (the 4D-CT MGD score) differentiating SGD from the use of preoperative parathyroid CT considers size only largest candidate lesion.
Radiotherapy, an essential modality in cancer treatment, frequently induces fibrotic processes the skin, including accumulation of extracellular matrix. Transforming growth factor-β is regulating matrix gene expression and dependent on Smad3, intracellular mediator/transcription factor. Our study characterized genetic involved during radiation-induced fibrosis. We performed Smad3 silencing attempt to abrogate effects radiation.Laboratory research.University laboratory.C57 murine dermal...
In most mammals, removing one lung (pneumonectomy) results in the compensatory growth of remaining lung. mice, stereological observations have demonstrated an increase number mature alveoli; however, anatomic evidence early phases alveolar has remained elusive. To identify changes microstructure associated with neoalveolarization, we used tissue histology, electron microscopy, and synchrotron imaging to examine configuration duct after murine pneumonectomy. Systematic histological...
Objectives: The mesothelium, the surface layer of heart, lung, bowel, liver and tunica vaginalis, is a complex tissue implicated in organ-specific diseases regenerative biology; however, mechanism mesothelial repair after surgical injury unknown. Previous observations indicated seeding denuded mesothelium by free-floating cells may contribute to healing. In this study, we investigated prevalence pleural fluid during 7 days following pulmonary surgery. Study design: Flow cytometry was...
Since bone repair and regeneration depend on vasculogenesis osteogenesis, both of these processes are essential for successful vascularized engineering. Using adipose-derived stem cells (ASCs), we investigated temporal gene expression profiles, as well nodule endothelial tubule formation capacities, during osteogenic vasculogenic ASC lineage commitment. Osteoprogenitor-enriched cell populations were found to express RUNX2, MSX2, SP7 (osterix), BGLAP (osteocalcin), SPARC (osteonectin), SPP1...
In many mammals, including rodents and humans, removal of one lung results in the compensatory growth remaining lung; however, mechanism is unknown. Here, we investigated changes morphology phenotype pleural cells after pneumonectomy. Between days 1 3 pneumonectomy, expressing α-smooth muscle actin (SMA), a cytoplasmic marker myofibroblasts, were significantly increased pleura compared to surgical controls (p < .01). Scanning electron microscopy surface post-pneumonectomy demonstrated...
In many mammals, including humans, removal of one lung (pneumonectomy) results in the compensatory growth remaining lung. Compensatory involves not only an increase size, but also number alveoli peripheral lung; however, process neoalveolarization remains poorly understood. Here, we show that expression α-smooth muscle actin (SMA)-a cytoplasmic protein characteristic myofibroblasts-is induced pleura following pneumonectomy. SMA induction appears to be dependent on pleural deformation...
Hyperthermic intraperitoneal chemotherapy (HIPEC) during cytoreductive surgery (CRS) is typically reserved for a complete or optimal cytoreduction. There the potential therapeutic effect of HIPEC with an incomplete cytoreduction, particularly near cytoreductions.Retrospective review cytoreductions (R2b, R2c) appendiceal and colorectal primaries. Primary endpoints were overall survival (OS) progression-free (PFS). Subgroup analysis primary etiology specific score.A total 121 cases CRS, 74 CRS...