A5084589251- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- RNA modifications and cancer
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Multiple Sclerosis Research Studies
- Neurological disorders and treatments
- Cerebrovascular and Carotid Artery Diseases
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
- Circular RNAs in diseases
- Cardiomyopathy and Myosin Studies
- Plant-based Medicinal Research
- Protein Kinase Regulation and GTPase Signaling
- Advanced MRI Techniques and Applications
- Medical Image Segmentation Techniques
- Cervical and Thoracic Myelopathy
- Retinal Imaging and Analysis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- MicroRNA in disease regulation
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Ion channel regulation and function
- Prion Diseases and Protein Misfolding
University Hospital of Basel
2019-2025
University of Basel
2019-2025
University Medical Center Freiburg
2024
University of Freiburg
2024
University College London
2024
National Hospital for Neurology and Neurosurgery
2024
Baker Heart and Diabetes Institute
2012-2021
Hospital Base
2020
AimsCirculating microRNAs (miRNAs) have attracted major interest as biomarkers for cardiovascular diseases. Since RNases are abundant in circulating blood, there needs to be a mechanism protecting miRNAs from degradation. We hypothesized that microparticles (MP) represent protective transport vehicles and these specifically packaged by their maternal cells.
P2Y12 blockade improves patient outcomes after myocardial infarction. As well as antithrombotic effects, anti-inflammatory effects may contribute to this beneficial clinical outcome. Here we aimed identify potential of receptor blockers on monocytes and macrophages. Using flow cytometry, migration assays, chambers RNA microarrays, investigated the adenosine diphosphate (ADP) blood monocytes, THP-1 differentiation -expressing platelets can form aggregates with in circulating blood. Mediated...
Abstract Background With the approval of disease-modifying treatments for 5q-spinal muscular atrophy (SMA), there is an increasing need biomarkers disease course and therapeutic response monitoring. Radially sampled Averaged Magnetization Inversion Recovery Acquisitions (rAMIRA) MR-imaging enables spinal cord (SC) gray matter (GM) delineation quantification in vivo. This study aims to assess SC GM patients with 5q-SMA its associations clinical disability. Methods Twenty-one twenty-one age-...
ABSTRACT Disorders of the central nervous system, including neurodegenerative diseases, frequently affect brainstem and can present with focal atrophy. This study aimed to (1) optimize deep learning‐based segmentation for a wide range pathologies T1‐weighted image acquisition parameters, (2) conduct systematic technical clinical validation, (3) improve quality in presence lesions, (4) make an optimized tool available public use. An intentionally heterogeneous ground truth dataset ( n = 257)...
Abstract Background and purpose In amyotrophic lateral sclerosis (ALS), there is an unmet need for more precise patient characterization through quantitative, ideally operator‐independent, assessments of disease extent severity. Radially sampled averaged magnetization inversion recovery acquisitions (rAMIRA) magnetic resonance imaging enables gray matter (GM) white (WM) area quantitation in the cervical thoracic spinal cord (SC) with optimized contrast. We aimed to investigate rAMIRA‐derived...
Abstract Neurodegenerative disorders, such as Alzheimer's disease (AD) and progressive forms of multiple sclerosis (MS), can affect the brainstem are associated with atrophy that be visualized by MRI. Anatomically accurate, large‐scale assessments challenging due to lack automated, accurate segmentation methods. We present a novel method for volumetry using fully‐automated approach based on multi‐dimensional gated recurrent units (MD‐GRU), deep learning semantic employing convolutional...
Background Radially sampled averaged magnetization inversion-recovery acquisition (rAMIRA) imaging shows hyperintensity in the lateral corticospinal tract (CST) patients with motor neuron diseases. Purpose To systematically determine accuracy of sign for detecting amyotrophic sclerosis (ALS) at rAMIRA MRI. Materials and Methods This study included prospectively acquired data from participants ALS other disease studies University Hospital Basel, Switzerland. All underwent 3-T axial...
Background: MR imaging of the spinal cord (SC) gray matter (GM) at cervical and lumbar enlargements' level may be particularly informative in lower motor neuron disorders, e. g., muscular atrophy, but also other neurodegenerative or autoimmune diseases affecting SC. Radially sampled averaged magnetization inversion recovery acquisition (rAMIRA) is a novel approach to perform SC clinical settings with favorable contrast well-suited for GM quantitation. However, before applying rAMIRA studies,...
To evaluate cervical and thoracic spinal cord (SC) gray matter (GM) atrophy its association with disability in patients Amyotrophic Lateral Sclerosis (ALS).
<h3>Objective:</h3> To evaluate the association between spinal cord (SC) gray matter (GM) atrophy and Motor Unit Number Index (MUNIX) in patients with 5q-Spinal Muscular Atrophy (SMA). <h3>Background:</h3> There is an unmet need for valid imaging markers to monitor disease course therapeutic outcome SMA. The novel rAMIRA (radially sampled Averaged Magnetization Inversion Recovery Acquisitions) method enables high in-plane resolution MR-imaging improved contrast of SC GM clinically feasible...
<h3>Objective:</h3> To prospectively evaluate cervical spinal cord (SC) gray matter (GM) area and its association with upper limb function in patients 5q-Spinal Muscular Atrophy (SMA) using rAMIRA (radially sampled Magnetization Inversion Recovery Acquisitions) MR-imaging. <h3>Background:</h3> With the approval of first disease modifying treatments for SMA, there is an increasing need biomarkers that allow easy to perform, reliable, valid course- therapeutic response monitoring. The novel...
Background: Brainstem-mediated functions are impaired in neurodegenerative diseases and aging. Atrophy can be visualized by MRI. This study investigates extrinsic sources of brainstem volume variability, intrinsic anatomical the influence age sex on volumes healthy subjects. We aimed to develop efficient normalization strategies reduce effects anatomic variability volumetry. Methods: Brainstem segmentation was performed from MPRAGE data using our deep-learning-based algorithm MD-GRU. The...
Objective: To investigate medulla oblongata (MO), pons and mesencephalon atrophy on brain 3D T1-weighted images in early stage patients with Multiple Sclerosis (MS) using a fully-automated deep learning-based segmentation approach. Background: Brainstem (BS) involvement is regarded as bad prognostic sign can limit life expectancy MS. In contrast to cortical, subcortical spinal cord atrophy, BS has not been systematically investigated Design/Methods: A novel, approach (Sander et al. 2019) was...