A5106484073- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Sarcoma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Prenatal Screening and Diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Regional Development and Environment
- Bone Tumor Diagnosis and Treatments
- Myasthenia Gravis and Thymoma
- Lung Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Neonatal Health and Biochemistry
- Genetic and rare skin diseases.
- Shoulder and Clavicle Injuries
- Pregnancy and preeclampsia studies
- Fetal and Pediatric Neurological Disorders
- Diet and metabolism studies
- Hair Growth and Disorders
Zhongda Hospital Southeast University
2025
Shanghai Skin Disease Hospital
2023
Tongji University
2023
Guangzhou University of Chinese Medicine
2023
China Pharmaceutical University
2022
People's Hospital of Bishan District
2022
East China Jiaotong University
2021
University of Alberta
2016
Zhejiang University
2015
Children's Hospital of Zhejiang University
2011-2015
Background: Diabetic nephropathy is a primary cause of kidney failure. Persistent hyperglycemia causes metabolic perturbations epigenetically dysregulating gene expression in renal cells, thereby leading to diabetic pathogenesis. On analyzing the GEO database by using machine learning algorithms, our preliminary results demonstrated that growth arrest and DNA damage-inducible 45α (GADD45α) might serve as key regulators nephropathy. Furthermore, emerging evidence has shown R-loops,...
Progressive loss and dysfunction of islet β-cells has not yet been solved in the treatment diabetes. Regenerating protein (Reg) identified as a trophic factor which is demonstrated to be associated with pancreatic tissue regeneration. We previously produced recombinant Reg3α (rReg3α) proved that it protects against acute pancreatitis mice. Whether rReg3α diabetes elusive. In present study, stimulated MIN6 cell proliferation resisted STZ-caused death. The protective effect was also found...
AbstractThis study investigated the protective effect of dapagliflozin on H9c2 cardiomyocyte function under high glucose and hypoxia/reoxygenation (HG-H/R) conditions identified underlying molecular mechanisms. Dapagliflozin reduced level lactate dehydrogenase reactive oxygen species in cardiomyocytes HG-H/R was accompanied by a decrease caspase-3/9 activity. In addition, significantly mitochondrial permeability transition pore opening increased ATP content, upregulation OPA1 with...
Rationale: Investigators have postulated that mediastinal granulomatous inflammation is associated with prolonged overall survival in patients cancer.Objectives: We sought to determine whether affects a history of treated cancer.Methods: Patients cancer who underwent endobronchial ultrasound–transbronchial needle aspiration (EBUS-TBNA) for evaluation or hilar lymphadenopathy were grouped based on they had benign without granulomas. Overall from the date EBUS-TBNA cancer-related death last...
<i>Aims:</i> To determine whether administration of long-acting polyethylene glycol moiety covalently linked to recombinant human growth hormone (PEG-rhGH) can be efficacious in the treatment small for gestational age (SGA) rats and characterize its effects on metabolic parameters. <i>Methods:</i> 20 pregnant were randomly divided into undernourished standard nourished groups. SGA or appropriate (AGA) offspring from each then assigned receive either PEG-rhGH normal...
Aims
Maturity-onset diabetes of the young(MODY), a monogenic form diabetes, has more than 8 well-known subtypes: MODY1(hepatocyte nuclear factor-4A, HNF4A), MODY2(glucokinase, GCK), MODY3(hepatocyte factor-1A, HNF1A), MODY4(pancreatic and duodenal homeobox, PDX), MODY5(hepatocyte factor-1B, HNF1B), MODY6(neuronal differentiation 1, NEUROD1), MODY7(carboxyl ester lipase, CEL) MODY8(insulin, INS). The molecular pathology, clinical manifestations treatment MODYs are different reviewed. Key...
This study was aimed to evaluate the diagnostic performance of ultrasound (US) in differentiating trichilemmal cysts (TCs) from epidermoid (ECs).Based on clinical and features, a prediction model established validated. 164 pilot cohort another 69 validation diagnosed with TCs or ECs histopathologically were evaluated. The same radiologist performed all examinations.For clinic tended occur females compared (66.7 vs 28.5%; P < .001). In addition, prone hairy area (77.8 13.1%; For internal...
患儿,女,14天,因发热伴气促2天收入新生儿重症监护室(NICU).患儿入院前2天出现发热,体温波动于38.5℃左右,伴气促明显,无咳嗽,无皮肤巩膜黄染,无吐奶,无哭吵不安,至当地医院就诊,查血气电解质提示pH值7.114,二氧化碳分压17.1 mm Hg(1 Hg=0.133 kPa),氧分压56.4mm Hg,随机血糖39 mmol/L,碳酸氢根离子5.2 mmol/L,实际碱剩余22 mmol/L,血钠141 mmol/L,血钾4.8 mmol/L,血氯120mmol/L,予生理盐水扩容后转入本院NICU.患儿系第1胎第1产,孕39周,剖宫产,出生体重3 450 g,出生身长50 cm,生后配方奶喂养,奶量约550 ml/d,尿量多,约500 ml/d,大便正常。
Objective:To analyse the prenatal diagnostic value of ultrasound in umbilical cord knot(UCK) and correlation UCK fetal perinatal outcome.Methods:Firstly, retrospective analysis was conducted on clinical data newborns or induced fetuses with UCK.Secondly,the incidence its relationship outcome were summarized analyzed.Then,the image characteristics diagnosing analyzed.Finally,fetuses who diagnosed as after delivery group, control group 200 cases randomly selected from other normal fetuses.The...