A5047769516- Reproductive Biology and Fertility
- Prenatal Screening and Diagnostics
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Cervical Cancer and HPV Research
- Sperm and Testicular Function
- Endometrial and Cervical Cancer Treatments
- Genetic Syndromes and Imprinting
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Sexual Differentiation and Disorders
- Reproductive Health and Technologies
- Genomic variations and chromosomal abnormalities
- Cancer Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hypothalamic control of reproductive hormones
- Congenital Anomalies and Fetal Surgery
- Molecular Biology Techniques and Applications
- Ectopic Pregnancy Diagnosis and Management
- Immunodeficiency and Autoimmune Disorders
- Cancer-related molecular mechanisms research
- Preterm Birth and Chorioamnionitis
- Reproductive Physiology in Livestock
- Ovarian cancer diagnosis and treatment
Gdańsk Medical University
2005-2024
Aarhus University Hospital
2020
Sapienza University of Rome
2020
Copenhagen University Hospital
2020
Johns Hopkins University
2020
University of Copenhagen
2020
University of Gdańsk
2020
Rutgers, The State University of New Jersey
2007
Wojewódzki Szpital Specjalistyczny Nr 2
1998
Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in oocytes from females aged 9 to 43 years report that aneuploidy follows a U-curve. Specific error types show different age dependencies, providing quantitative explanation for the Whole-chromosome nondisjunction events are preferentially associated with increased young girls, whereas centromeric more...
Abstract The field of preimplantation genetic testing (PGT) is evolving fast, and best practice advice essential for regulation standardisation diagnostic testing. previous ESHRE guidelines on PGD, published in 2005 2011, are considered outdated, the development new papers outlining recommendations good PGT was necessary. current paper provides technical aspects embryo biopsy covers procedure, cryopreservation laboratory issues training, addition to strengths limitations specific currently...
The aim of the study was to assess granulocyte colony-stimulating factor (G-CSF) effects on unresponsive thin (<7 mm) endometrium in women undergoing vitro fertilization (IVF). We included thirty-seven subjects who had day triggering ovulation. These patients also failed achieve an adequate endometrial thickness at least one their previous IVF cycles. In all time infusion G-CSF, 6,74 ± 1,75 mm, and, after infusion, it increased significantly 8,42 1,73 mm. When we divided group into two...
The aim of the study was to assess granulocyte-colony stimulating factor (G-CSF) effect on unresponsive thin (<7 mm) endometrium in women undergoing frozen-thawed embryo transfer at blastocyst stage. A total 62 with were included study, which, 29 received a G-CSF infusion and 33 who opted out served as controls. Patients both groups had similar endometrial thickness time initial evaluation: 6.50 mm (5.50-6.80) 6.40 (5.50-7.0) control group. However, after increased significantly group...
Human follicular fluid (hFF) is a natural environment of oocyte maturation, and some components hFF could be used to judge capability for fertilization further development. In our pilot small-scale study three samples from four donors (12 in total) were analyzed determine which proteins/peptides differentiate individual oocytes are patient-specific. Ultrafiltration was fractionate high-molecular-weight (HMW) proteome (>10 kDa) low-molecular-weight (LMW) peptidome (<10 fractions. HMW LMW...
Female somatic X-chromosome inactivation (XCI) balances the X-linked transcriptional dosages between sexes, randomly silencing maternal or paternal X chromosome in each cell of 46,XX females. Skewed XCI toward one parental has been observed association with ageing and some female carriers diseases. To address problem non-random XCI, we quantified skew different biological samples naturally conceived females age groups girls after vitro fertilization (IVF). Generally, differed saliva, blood,...
Has PGD-HLA been successful relative to diagnostic and clinical efficacy?The efficacy of protocols was found lower in this study comparison published that reported for general PGD by ESHRE (78.5 vs 94.1% 92.6%, respectively), while the has proven very difficult assess due inadequate follow-up both ART/PGD HSCT procedure outcomes.The first cases were 2001. It is now a well-established procedure, with an increasing number cycles performed every year. However, still offered relatively few...
ABSTRACT Integration of human papillomavirus (HPV) DNA into host genome occurs early in cancer development and is probably an important event malignant transformation cervical cancer. The HPV integration usually disrupts E2 gene open reading frames. It results the lack suppressor synthesis E6 E7 products which, turn, leads to overexpression genes. oncogenic types (HPV16, -18, -45, -58) can be present as episomes or may integrate chromosomes. Sixty-six patients positive for HPV16 were tested...
Summary Presence of vacuoles and degree sperm DNA damage are considered to be the basic factors used for assessment fertilization capacity. We aimed investigate link between these two parameters. According our knowledge, this is first study where Comet assay was assess fragmentation categorized by Motile Sperm Organelle Morphology Examination ( MSOME ) Grades. Semen samples from 10 patients were assessed. Spermatozoa graded into four groups according Vanderzwalmen's criteria. A total 3930...
Preimplantation genetic diagnosis (PGD) is well established method for treatment of problems associated with infertility. Moreover, PGD next-generation sequencing (NGS) provide new possibilities and parameters evaluation in, example, aneuploidy screening. The aim the study was to report successful pregnancy outcome following NGS as 24 chromosome screening in case Robertsonian translocation. Day 3 embryos chromosomal performed two consecutive vitro fertilization (IVF) cycles, first...
1. Handyside AH. 24-chromosome copy number analysis: a comparison of available technologies. Fertil Steril. 2013; 100: 595–602. Google Scholar
Sperm tail morphology and motility have been demonstrated to be important factors in determining sperm quality for vitro fertilization. However, many existing computer-aided analysis systems leave the out of analysis, as detecting a few pixels is challenging. Moreover, some publicly available datasets classifying morphological defects contain images limited only head. This study focuses on segmentation full sperm, which consists head parts, appear alone groups. We re-purpose Feature Pyramid...
The purpose of this prospective study was to describe the incidence and distribution pattern human papillomavirus (HPV) DNA in intraoperative dissected lymph nodes relate pathological confirmation metastasis.