A5100712380- Zebrafish Biomedical Research Applications
- Angiogenesis and VEGF in Cancer
- Erythrocyte Function and Pathophysiology
- Elbow and Forearm Trauma Treatment
- Characterization and Applications of Magnetic Nanoparticles
- Cerebrovascular and genetic disorders
- Immune cells in cancer
- Immune Cell Function and Interaction
- 3D Printing in Biomedical Research
- Epigenetics and DNA Methylation
- Neurobiology and Insect Physiology Research
- Facial Trauma and Fracture Management
- Immune responses and vaccinations
- Streptococcal Infections and Treatments
- Facial Rejuvenation and Surgery Techniques
- Pluripotent Stem Cells Research
- Vascular Malformations Diagnosis and Treatment
- Shoulder Injury and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Developmental Biology and Gene Regulation
- Invertebrate Immune Response Mechanisms
- Eosinophilic Disorders and Syndromes
- Periodontal Regeneration and Treatments
- Blood disorders and treatments
- Phagocytosis and Immune Regulation
RIKEN
2024
University of Sheffield
2018-2022
Immunité et Cancer
2018
Guangzhou Medical University
2018
Guangzhou Institutes of Biomedicine and Health
2018
Novartis (China)
2016
Wuhan Puai Hospital
2015
Huazhong University of Science and Technology
1990-2015
Xijing Hospital
2014
Air Force Medical University
2014
Abstract Angiogenesis requires co-ordination of multiple signalling inputs to regulate the behaviour endothelial cells (ECs) as they form vascular networks. Vascular growth factor (VEGF) is essential for angiogenesis and induces downstream pathways including increased cytosolic calcium levels. Here we show that transmembrane protein 33 ( tmem33 ), which has no known function in multicellular organisms, mediate effects VEGF both zebrafish human ECs. We find localises endoplasmic reticulum ECs...
Several studies have shown a clear association between periodontal disease and increased risk of cardiovascular disease. Porphyromonas gingivalis (Pg), key oral pathogen, its cell surface-expressed gingipains, induce oedema in zebrafish larvae infection model although the mechanism these vascular effects is unknown. Here, we aimed to determine whether Pg-induced damage mediated by gingipains. In vitro, human endothelial cells from different beds were invaded wild-type (W83) but not...
The class III PI3-kinase (PIK3C3) is an enzyme responsible for the generation of phosphatidylinositol 3-phosphate (PI3P), a critical component vesicular membrane. Here, we report that PIK3C3 deficiency in zebrafish results intestinal injury and inflammation. In pik3c3 mutants, gut tube forms but fails to be maintained. Gene expression analysis reveals barrier-function-related inflammatory bowel disease (IBD) susceptibility genes (e-cadherin, hnf4a, ttc7a) are suppressed, while response...
Abstract Transplant rejection remains a major challenge, driven primarily by the activation of alloreactive T cells. While enhancement PD‐L1 checkpoint molecules has exhibited potential in inhibiting cell activity, its efficacy is often hindered limited specificity and inadequate efficiency. Herein, novel dual‐phase immune modulation strategy developed which CTLA4‐Ig provide distinct, non‐redundant inhibitory signals during initial phase post‐activation stably expressed on macrophages...
The transcriptional repressors Gfi1(a) and Gfi1b are epigenetic regulators with unique overlapping roles in hematopoiesis. In different contexts, Gfi1 restrict or promote cell proliferation, prevent apoptosis, influence fate decisions, essential for terminal differentiation. Here, we show primitive red blood cells (prRBCs) that they can also set the pace cellular zebrafish, prRBCs express 2 of 3 zebrafish Gfi1/1b paralogs, Gfi1aa Gfi1b. recently identified gfi1aa gene trap allele qmc551...
Following the formation of new blood vessels, vascular remodelling ensues to generate a hierarchical network tubes with optimal connections and diameters for efficient perfusion tissues. How transitions in endothelial cell (EC) number shape are coordinated define vessel diameter during development remains an open question. In this study, we discovered EC deformations, rearrangements transient self-seam junctions as key mechanisms that explain negative relationship between diameter....
Abstract Nascent vascular networks adapt to the increasing metabolic demands of growing tissues by expanding via angiogenesis. As expand, blood vessels remodel, progressively refining connectivity generate a more haemodynamically efficient network. This process is driven interplay between endothelial cell (EC) signalling and flow. While much known about angiogenesis, considerably less understood mechanisms underlying vessel remodelling Here we employ zebrafish sub-intestinal venous plexus...
Objective To investigate the effect of cosmetic surgery on facial soft tissue injuries. Methods The clinical data 52 patients with injuries from June 2013 to 2014 were analyzed retrospectively. And plastic surgical techniques applied early treatment in patients, according size defect and degree deformity different was chosen, such as skin flap or graft repair wound surfaces. In this process, one must follow sterile noninvasive principle strictly emphasis technique entire debridement,...
Objective: To investigate whether excessive erythroid cell apoptosis and/or suppression of proliferation would be implicated in the pathogenesis anemia associated with lymphoma. Methods: Bone marrow (BM) (CD71+, GPA+ (annexin V) and (Ki-67) were measured by flow cytometry lymphoma patients normal donors. Results: BM CD71+ cells showed a significantly greater proportion apoptotic than samples. Proliferation rate was also increased Conclusion: Increased may contribute to characteristic this...