A5029895164- CAR-T cell therapy research
- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Cytomegalovirus and herpesvirus research
- Fungal Infections and Studies
- Viral Infections and Outbreaks Research
- Bacillus and Francisella bacterial research
- Iron Metabolism and Disorders
- Bacteriophages and microbial interactions
- Breastfeeding Practices and Influences
- Toxoplasma gondii Research Studies
- Trace Elements in Health
- Viral Infections and Vectors
- Healthcare Decision-Making and Restraints
- Nosocomial Infections in ICU
- Gastrointestinal motility and disorders
- Malaria Research and Control
- Zoonotic diseases and public health
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- Milk Quality and Mastitis in Dairy Cows
National Institute of Allergy and Infectious Diseases
2018-2024
National Institutes of Health
2007-2024
Antwerp University Hospital
2018
University of Antwerp
2017
Johns Hopkins Medicine
2002-2015
Johns Hopkins University
2001-2015
Johns Hopkins Hospital
2013
University of Maryland, Baltimore
2007
Abstract Background The epidemiology of invasive mold infections ( IMI ) in transplant recipients differs based on geography, hosts, preventative strategies, and methods diagnosis. Methods We conducted a retrospective observational study to evaluate the proven probable , using prior definitions, among all adult hematopoietic stem cell HSCT solid organ SOT era “classic” culture‐based diagnostics (2000–2009). Epidemiology was evaluated before after an initiative begun increase bronchoscopy...
Abstract B-cell–depleting therapies may lead to prolonged disease and viral shedding in individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) this persistence raises concern for evolution. We report sequencing of early late samples from a 335-day infection an immunocompromised patient. The virus accumulated unique deletion the amino-terminal domain spike protein, complete ORF7b ORF8, first its kind Unique mutations found study highlight importance analyzing...
Diagnosing ventilator-associated pneumonia (VAP) is difficult, and misdiagnosis can lead to unnecessary prolonged antibiotic treatment. We sought quantify characterize unjustified antimicrobial use for VAP identify risk factors continuation of antibiotics in patients without after 3 days.Patients suspected having were identified 6 adult intensive care units (ICUs) over 1 year. A multidisciplinary adjudication committee determined whether the ICU team's diagnosis therapy justified, using...
Toxoplasmosis is the most common cause of infectious uveitis in Brazil, with a higher frequency South country. We have collected samples from porcine tongue and diaphragm obtained both large small abattoirs used molecular biological technique to determine prevalence infection RFLP analysis type parasites. Seventeen out 50 (34%) 33 (66%) demonstrated positive PCR reaction for T. gondii restriction four revealed that all had I genotype at SAG2. However, when other unlinked loci were analyzed,...
Human cytomegalovirus (CMV) infection and disease remains a significant cause of morbidity mortality for hematopoietic cell transplantation (HCT) recipients. Disruption or weak reconstitution virus-specific cellular immune function, such as with certain HCT approaches, poses risk CMV-related complications. The incidence factors CMV the nature were evaluated retrospectively among 356 consecutive recipients transplanted at National Institutes Health using all graft sources, including bone...
ABSTRACT Anemia is an important complication of malaria, and its pathogenesis not well understood. To gain insight into potential age-related relationships between tumor necrosis factor alpha (TNF-α), interleukin 10 (IL-10), erythropoietin, anemia during acute 273 children ages 12 to 120 months presenting with acute, uncomplicated malaria in Kampala, Uganda, were monitored at enrollment 3 7 days later. Younger had higher geometric mean TNF-α, α 1 -acid glycoprotein (AGP) concentrations than...
B-cell depleting therapies may lead to protracted disease and prolonged viral shedding in individuals infected with SARS-CoV-2. Viral persistence the setting of immunosuppression raises concern for evolution.Amplification sub-genomic transcripts E gene (sgE) was done on nasopharyngeal samples over course 355 days a patient SARS-CoV-2 who had previously undergone CAR T cell therapy persistently positive swabs. Whole genome sequencing performed from patient's original presentation 10 months...
ObjectivesThe optimal duration of antibiotic therapy for uncomplicated Gram-negative bacteraemia remains undefined. Our objective was to compare clinical outcomes receiving short (7–10 days) versus prolonged (>10 durations children with bacteraemia.
Abstract Prototheca wickerhamii is a rare cause of cutaneous and systemic infection that requires long treatment courses with potentially toxic medications. We describe patient protothecosis refractory to triazole monotherapy who experienced clinical radiographic improvement the novel oral lipid nanocrystal formulation amphotericin B without experiencing toxicity.
We evaluated 222 hospitalized patients whose clinical isolates were tested using standard methods and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF). MALDI-TOF could have reduced time to appropriate therapy for 28.8% 44.6% based on the treating physician's choices stewardship team recommendations, respectively. Clinicians should be aware of scenarios in which can optimize antibiotic therapy.
Serious bacterial infections (SBI) can lead to devastating complications with CD19 CAR T cells and cytokine release syndrome (CRS). Little is known about consequences of risk factors for SBI novel T-cell constructs or CRS complicated by HLH-like toxicities. We report on three patients B-cell acute lymphoblastic leukemia treated CD22 who developed CRS-associated HLH. Serum profiling revealed sustained elevations well beyond resolution, suggesting ongoing systemic inflammation. Heightened...
The epidemiology and microbiology of subclinical mastitis, a risk factor for perinatal HIV transmission, have not been well characterized. In all, 250 HIV-infected women were followed from two weeks to 12 months postpartum in Blantyre, Malawi, mastitis was assessed by breast milk leukocyte counts. point prevalence at 2, 4, 6, 10, 14 weeks, 9, 12.2%, 7.8%, 6.8%, 3.7%, 10.6%, 5.1%, 4.9%, 1.9%, respectively ( P = 0.002), 27.2% had least one episode mastitis. There no significant relationship...