A5082577394- Liver physiology and pathology
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Sports Performance and Training
- Endoplasmic Reticulum Stress and Disease
- Pancreatitis Pathology and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Angiogenesis and VEGF in Cancer
- Drug-Induced Adverse Reactions
- High Altitude and Hypoxia
- Drug-Induced Hepatotoxicity and Protection
- ATP Synthase and ATPases Research
- Sports and Physical Education Studies
- Cell Adhesion Molecules Research
- Cardiovascular Effects of Exercise
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Air Traffic Management and Optimization
- Advanced Glycation End Products research
- Glycosylation and Glycoproteins Research
- Biochemical and Molecular Research
- Liver Disease and Transplantation
- Cell death mechanisms and regulation
- Erythrocyte Function and Pathophysiology
University of Girona
2024
Escuela Nacional de Sanidad
2023
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2018-2019
National Institute of Physical Education of Catalonia
2019
Universitat de Barcelona
2019
Institut d'Investigacions Biomèdiques de Barcelona
2010-2016
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2016
Centro de Investigación Biomédica en Red
2015
Hospital Clínic de Barcelona
2015
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010-2013
Background & AimsLiver fibrosis, an important health concern associated to chronic liver injury that provides a permissive environment for cancer development, is characterized by accumulation of extracellular matrix components mainly derived from activated hepatic stellate cells (HSCs). Axl, receptor tyrosine kinase and its ligand Gas6, are involved in cell differentiation, immune response carcinogenesis.MethodsHSCs were obtained WT Axl−/− mice, treated with recombinant Gas6 protein (rGas6),...
CD5-like (CD5L) is a soluble scavenger cysteine-rich protein that modulates inflammatory responses. We studied the involvement of CD5L in liver cancer. Immunohistochemistry (IHC) 60 hepatocellular carcinomas and 34 adjacent nontumor livers, showed staining was higher tumor than tissue (Mann-Whitney test; P = 0.0039). High correlated with elevated proliferation (Ki67, linear regression; < 0.0001) lower patient event-free survival (log-rank; 0.0185). Accordingly, expression detected cancer...
Growth arrest–specific gene 6 (GAS6) promotes growth and cell survival during tissue repair development in different organs, including the liver. However, specific role of GAS6 liver ischemia/reperfusion (I/R) injury has not been previously addressed. Here we report an early increase serum levels after I/R exposure. Moreover, unlike wild-type (WT) mice, Gas6 −/− mice were highly sensitive to partial hepatic I/R, with 90% dying within 12 hours reperfusion because massive hepatocellular...
// Milica Stefanovic 1 , Anna Tutusaus Guillermo A. Martinez-Nieto Cristina Bárcena Estefania de Gregorio Catia Moutinho 2 Elisabet Barbero-Camps Alberto Villanueva 3 Colell Montserrat Marí Carmen García-Ruiz 1, 4 Jose C. Fernandez-Checa 4, 5 Albert Morales Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, Barcelona, Catalonia, Spain Cancer Epigenetics Biology Program (PEBC), Bellvitge Biomedical Research Institute, Translational Laboratory, Catalan Institute Oncology - Liver...
Hepatocellular carcinoma (HCC) frequently develops in a pro-inflammatory and pro-fibrogenic environment with hepatic stellate cells (HSCs) remodeling the extracellular matrix composition. Molecules secreted by liver tumors contributing to HSC activation peritumoral stromal transformation remain be fully identified. Here we show that conditioned medium from HCC cell lines, Hep3B HepG2, induced primary mouse HSCs transdifferentiation, characterized profibrotic properties collagen modification,...
Chronic hepatic inflammation leads to liver fibrosis, which may progress cirrhosis, a condition with high morbidity. Our aim was assess the as yet unknown role of innate immunity protein CD5L in fibrosis.CD5L measured by ELISA plasma samples from cirrhotic (n = 63) and hepatitis 39) patients, healthy controls 7), immunohistochemistry tissue 12), quantitative RT-PCR mouse cell subsets isolated sorting. Recombinant (rCD5L) administered into murine model CCl4-induced damage, fibrosis immune...
In the air traffic management (ATM) environment, controllers (ATCos) and flight crews, (FCs) communicate via voice to exchange different types of data such as commands, readbacks (confirmation reception command) information related environment. Speech recognition can be used in these exchanges support ATCos their work; each time a identification or callsign is mentioned by controller pilot, recognised through automatic speech (ASR) highlighted on ATCo screen increase situational awareness...
Background Hypoxia-mediated HIF-1α stabilization and NF-κB activation play a key role in carcinogenesis by fostering cancer cell survival, angiogenesis tumor invasion. Gangliosides are integral components of biological membranes with an increasingly recognized as signaling intermediates. In particular, ganglioside GD3 has been characterized proapoptotic lipid effector promoting death suppression survival pathways. Thus, our aim was to analyze the hypoxia susceptibility hepatocarcinoma cells...
Consequences of running mountain races on muscle damage were investigated by analysing serum enzymes and fibre-type-specific sarcomere proteins. We studied 10 trained amateur 6 highly runners who ran a 35 km 55 trail race (MTR), respectively. Levels creatine kinase (CK), CK-MB isoform (CK-MB), sarcomeric mitochondrial CK (sMtCK), transaminases (AST ALT), cardiac troponin I (cTnI) fast (FM) slow myosin (SM) isoforms, assessed before, 1 h, 24 h 48 after the beginning MTR. Significant SM...
Objetivo: El objetivo de este estudio fue analizar si la potencia es un buen indicador del rendimiento en competiciones bicicleta todo terreno (BTT), específicamente SuperCup cross country olímpico (XCO) BTT Banyoles-España. Metodología: Se monitorizó 10 ciclistas hombres profesionales XCO-BTT durante carrera y se analizó su relación con el las subidas, bajadas los tramos llanos vuelta más rápida. Resultados: encontró una correlación fuerte entre media (Potmed) (R² = -.652, p .041), muy...