A5047304195- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Liver physiology and pathology
- Testicular diseases and treatments
- Coronary Interventions and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Sperm and Testicular Function
- Phagocytosis and Immune Regulation
- Advanced MRI Techniques and Applications
- Cancer Mechanisms and Therapy
- Biomarkers in Disease Mechanisms
- Epigenetics and DNA Methylation
- Amino Acid Enzymes and Metabolism
- Pancreatitis Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Acute Myeloid Leukemia Research
- Chromosomal and Genetic Variations
- Hepatocellular Carcinoma Treatment and Prognosis
- Sphingolipid Metabolism and Signaling
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Multiple Myeloma Research and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- COVID-19 and healthcare impacts
- Advanced Radiotherapy Techniques
Zemun Hospital
2017-2025
Institut Català d'Oncologia
2020-2025
Institut d'Investigació Biomédica de Bellvitge
2020-2025
Duran i Reynals Hospital
2023-2024
Universitat de Barcelona
2024
Institut Català d'Ornitologia
2024
Ljubljana University Medical Centre
2016-2024
Institut d'Investigacions Biomèdiques de Barcelona
2010-2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2023
Institute for Cardiovascular Diseases of Vojvodina
2018
Background & AimsLiver fibrosis, an important health concern associated to chronic liver injury that provides a permissive environment for cancer development, is characterized by accumulation of extracellular matrix components mainly derived from activated hepatic stellate cells (HSCs). Axl, receptor tyrosine kinase and its ligand Gas6, are involved in cell differentiation, immune response carcinogenesis.MethodsHSCs were obtained WT Axl−/− mice, treated with recombinant Gas6 protein (rGas6),...
Growth arrest–specific gene 6 (GAS6) promotes growth and cell survival during tissue repair development in different organs, including the liver. However, specific role of GAS6 liver ischemia/reperfusion (I/R) injury has not been previously addressed. Here we report an early increase serum levels after I/R exposure. Moreover, unlike wild-type (WT) mice, Gas6 −/− mice were highly sensitive to partial hepatic I/R, with 90% dying within 12 hours reperfusion because massive hepatocellular...
// Anna Tutusaus 1, 2 , Milica Stefanovic 1 Loreto Boix 3 Blanca Cucarull Aynara Zamora Laura Blasco Pablo García de Frutos Maria Reig Jose C. Fernandez-Checa 4, 5 Montserrat Marí Colell Jordi Bruix and Albert Morales Department of Cell Death Proliferation, IIBB-CSIC, IDIBAPS, Barcelona, Spain Departament Biomedicina, Facultat Medicina, Universitat Barcelona Clinic Liver Cancer Group, Unit, Hospital Clínic University CIBEREHD, 4 Clinic, Research Center for Alcoholic Pancreatic Diseases, Keck...
// Milica Stefanovic 1 , Anna Tutusaus Guillermo A. Martinez-Nieto Cristina Bárcena Estefania de Gregorio Catia Moutinho 2 Elisabet Barbero-Camps Alberto Villanueva 3 Colell Montserrat Marí Carmen García-Ruiz 1, 4 Jose C. Fernandez-Checa 4, 5 Albert Morales Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, Barcelona, Catalonia, Spain Cancer Epigenetics Biology Program (PEBC), Bellvitge Biomedical Research Institute, Translational Laboratory, Catalan Institute Oncology - Liver...
Abstract Background Since cardiovascular disease is a major cause of death in patients with chronic kidney (CKD), echocardiographic risk stratification CKD may be clinically important, especially if left ventricular (LV) systolic function still preserved. Purpose To investigate the prognostic implications conventional (LV mass) and advanced parameters [global longitudinal strain (GLS) mechanical dispersion] dialysis-dependent preserved ejection fraction (LVEF). Methods A total 78 LVEF≥50%...
Cancer patients treated with radiotherapy in the abdominal and pelvic cavity develop radiation-induced enteritis, a condition that impairs their quality of life. Radiation injury depletes proliferative intestinal stem cells (ISCs); response to this, epithelium activates regenerative program facilitates healing intestine. However, mechanisms induce activation are poorly characterized. In this study, we induced enteritis mice through irradiation, mimicking clinical scenarios. Through imaging...
Hepatocellular carcinoma (HCC) frequently develops in a pro-inflammatory and pro-fibrogenic environment with hepatic stellate cells (HSCs) remodeling the extracellular matrix composition. Molecules secreted by liver tumors contributing to HSC activation peritumoral stromal transformation remain be fully identified. Here we show that conditioned medium from HCC cell lines, Hep3B HepG2, induced primary mouse HSCs transdifferentiation, characterized profibrotic properties collagen modification,...
The clinical manifestations of human metapneumovirus (hMPV) infection resemble those respiratory syncytial virus with the most severe disease occurring in infants, elderly, chronically ill, and immunocompromised hosts.We present a case 2-year-old girl undergoing intensive chemotherapy for Burkitt lymphoma who developed hMPV pneumonia. Rapid complete recovery was observed after treatment oral ribavirin intravenous immunoglobulin.As can cause pneumonia patients due to reports effective...
Patients treated with vincristine predictably develop peripheral neuropathy. The aim of our study was to investigate the pattern vincristine-induced neuropathy in children by nerve conduction studies and somatosensory-evoked potentials (SSEPs). We included data from 39 who received for various pediatric malignancies, we performed initial follow-up (after a minimum 4 doses 1.5 mg/m) 27 patients SSEPs 34 patients. On most prevalent symptoms were paresthesias (44%) constipation (22%), common...
The multikinase inhibitor regorafenib, approved as second-line treatment for hepatocellular carcinoma (HCC) after sorafenib failure, may induce mitochondrial damage. BH3-mimetics, inhibitors of specific BCL-2 proteins, are valuable drugs in cancer therapy to amplify mitochondrial-dependent cell death.
Purpose: To investigate the genetic basis of cisplatin resistance as efficacy cisplatin-based chemotherapy in treatment distinct malignancies is often hampered by intrinsic or acquired drug tumor cells.Experimental Design: We produced 14 orthoxenograft transplanting human nonseminomatous testicular germ cell tumors (TGCT) mice, keeping primary features terms genotype, phenotype, and sensitivity to cisplatin. Chromosomal alterations were evaluated matched cisplatin-sensitive their counterpart...
The aim of this multicentric study was to assess the impacts oxidative stress, inflammation, and presence small, dense, low-density lipoproteins (sdLDL) on antioxidative function high-density lipoprotein (HDL) subclasses distribution paraoxonase-1 (PON1) activity within HDL in patients with ST-segment elevation acute myocardial infarction (STEMI). In 69 STEMI 67 healthy control subjects, lipoproteins’ were separated using polyacrylamide gradient (3–31%) gel electrophoresis. relative...
We investigated circulating levels of inflammatory biomarkers pentraxin-3 (PTX3), cyclophilin A (CypA), and heparin-binding epidermal growth factor-like factor (HB-EGF); oxidative stress; antioxidant status markers in the patients with ST-segment elevation acute myocardial infarction (STEMI) to better understand a relationship between inflammation stress. examined impact stress on high values parameters. The study included 87 STEMI 193 controls. observed positive correlation PTX3 HB-EGF (ρ =...
OBJECTIVE To compare cardiac computed tomography (CT) with invasive coronary angiography (ICA) as the initial strategy in patients diabetes and stable chest pain. RESEARCH DESIGN AND METHODS This prespecified analysis of multicenter DISCHARGE trial (NCT02400229) 16 European countries was performed pain intermediate pretest probability artery disease. The primary end point a major adverse event (MACE) (cardiovascular death, nonfatal myocardial infarction, or stroke), secondary expanded MACE...
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Coronary bifurcation atherosclerosis depends on its angles, flow, and extensive branching. We investigate the ability of CT coronary angiography (CTCA) to determine atherosclerotic plaque characteristics "true" compared with intravascular ultrasound (IVUS) influence side branch (SB) fate after percutaneous intervention (PCI).The study included 70 patients 72 bifurcations. Most bifurcations were in left anterior descending-diagonal (Dg) territory [50 out (69.4%)]. Longitudinal evaluation at...
Introduction Telomeres are protective chromosomal ends. Short telomeres a proven biomarker of biological aging. We aimed to find an association telomere length and telomerase activity in circulating leukocytes thromboaspirates patients with acute myocardial infarction. Furthermore, the telomere-telomerase system oxidative stress markers (as common risk factors for coronary artery disease (CAD)) was tested. Material methods Patients were selected from admitted intensive care unit infarction...
<h3>Introduction/Background</h3> Treatment of locally advanced cervical cancer (LACC) is based on radical external beam radio-chemotherapy (EBRT/CHT) or exclusive chemotherapy (CT) in stage IVB. EBRT fields can be pelvic extended depending lymph node involvement. Paraaortic lymphadenectomy(PAL) the 'Gold Standard' to asses paraaortic Positron Emission Tomography ([18]FDG-PET/CT) plays a role diagnosing retroperitoneal involvement and distant metastases. We aimed evaluate contribution...
<h3>Introduction/Background</h3> In high-grade endometrial cancer (HGEC), the accuracy of tumor staging plays a pivotal role in determining therapeutic strategies and influencing patient prognoses. This study aimed to describe changes assess concordance International Federation Gynecology Obstetrics (FIGO-2009) before after surgery HGEC. <h3>Methodology</h3> A retrospective conducted at University Hospital Bellvitge (HUB), including 119 patients diagnosed with HGEC (grade-3 tumors), between...
<h3>Introduction/Background</h3> Despite the development of new targeted therapies for patients with ovarian cancer, surgery remains a fundamental cornerstone in its treatment, particularly management recurrences. Our objective is to present highly complex surgical case managed multidisciplinary, from indication postoperative care. <h3>Methodology</h3> A 61-year-old patient was suspected recurrence 21 months disease-free survival after completing her first-line treatment NACT+IDS+Adjuvant...