A5074658386- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Innovations in Medical Education
- Genomics and Chromatin Dynamics
- Acute Myeloid Leukemia Research
- Oral health in cancer treatment
- Immune Cell Function and Interaction
- Silymarin and Mushroom Poisoning
- Ocular Infections and Treatments
- HER2/EGFR in Cancer Research
- Religion, Spirituality, and Psychology
- Epigenetics and DNA Methylation
- Healthcare Quality and Management
- Medical and Biological Ozone Research
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Muscle metabolism and nutrition
- Glycosylation and Glycoproteins Research
- Global Health Workforce Issues
- Metabolism and Genetic Disorders
- Retinoids in leukemia and cellular processes
Mashhad University of Medical Sciences
2025
Washington University in St. Louis
2015-2024
Shahid Beheshti University of Medical Sciences
2013-2023
University of Kashan
2022
Islamic Azad University Boroujerd Branch
2019
Royal Derby Hospital
2016-2018
University of Kurdistan
2018
Isfahan University of Medical Sciences
2017
Iranshahr University
2017
Islamic Azad University, Karaj
2017
Abstract Despite over 20 years of clinical use, IL-2 has not fulfilled expectations as a safe and effective form tumour immunotherapy. Expression the high affinity IL-2Rα chain on regulatory T cells mitigates anti-tumour immune response its expression vascular endothelium is responsible for life threatening complications such diffuse capillary leak pulmonary oedema. Here we describe development recombinant fusion protein comprised cowpox virus encoded NKG2D binding (OMCP) mutated with poor...
Background: Antimicrobial resistance (AMR) has been a concerning public health issue even before the coronavirus disease 2019 (COVID-19) outbreak. However, impact of COVID-19 pandemic on AMR not comprehensively investigated. Objectives: The main objective this study was to investigate patterns before, during, and after pandemic. Methods: Data from hospital records cancer patients in hematology ward were obtained for cross-sectional using census sampling method January 2018 July 2023....
Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low resolution strategies (i.e., karyotypes, microarrays). We present the first large-scale whole-genome sequencing (WGS) study of 100 individuals from families with 9p-related including 85 unrelated probands through 9P-ARCH (Advanced Research in Chromosomal Health: Genomic, Phenotypic, Functional Aspects 9p-Related syndromes) research network. analyzed architecture these syndromes, highlighting...
Nectins are Ca(2+)-independent immunoglobulin-like cell adhesion molecules that compose a family of four members regulate several cellular activities such as movement, proliferation, survival, differentiation, polarization, and the entry viruses. Nectin-4 has recently emerged metastatis-associated protein in cancers. Here, we have evaluated association between expression clinical outcome patients with node-negative, T1/T2 breast cancers.The study group consisted 197 presenting primary...
// Laura Lupini 1, * , Felice Pepe 2, 8, Manuela Ferracin 3 Chiara Braconi 4 Elisa Callegari 1 Sara Pagotto 8 Riccardo Spizzo 5 Barbara Zagatti Paola Lanuti 6 Francesca Fornari 7 Reza Ghasemi 2 Renato Mariani-Costantini Luigi Bolondi Gramantieri George A. Calin 9 Silvia Sabbioni 10 Rosa Visone Angelo Veronese Massimo Negrini Department of Morphology, Surgery and Experimental Medicine, University Ferrara, Italy Unit General Pathology, Aging Research Center (Ce.S.I.), G. d'Annunzio Foundation,...
The present study aimed to investigate the antifungal activity of Nanoparticles (NPs) against amphotericin B-resistant Candida glabrata (C. glabrata) strains.Twelve resistant strains were isolated from archived clinical isolates. Antifungal was conducted according Clinical and Laboratory Standards Institute's (CLSI) guidelines, document M27-A3/S4. Scanning Electron Microscope (SEM) used observe morphological changes exposed each nanoparticle.Minimum Inhibitory Concentration (MIC)...
Abstract Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy worldwide. Development of chemoresistance and peritoneal dissemination EOC cells are major reasons for low survival rate. Targeting signal transduction pathways which promote therapy resistance metastatic key to successful treatment. Members ErbB family receptors over-expressed in play roles invasiveness. Despite this, single-targeted inhibitors have demonstrated limited activity chemoresistant EOC. In this...
ErbB-3 (HER-3) receptor is involved in tumor progression and resistance to therapy. Development of specific inhibitors impairing the activity an attractive tool for cancer therapeutics. MP-RM-1, a murine monoclonal antibody targeting human ErbB-3, has shown anticancer preclinical models. With aim provide novel candidates clinical use, we have successfully generated humanized version MP-RM-1. The antibody, named EV20, abrogates both ligand-dependent ligand-independent signaling several cell...
Transcriptional regulation of the HOXA genes is thought to involve CTCF-mediated chromatin loops and opposing actions COMPASS Polycomb epigenetic complexes. We investigated role these mechanisms at cluster in AML cells with common NPM1c mutation, which express both HOXB genes. CTCF binding locus conserved across primary samples, regardless gene expression, defines a continuous domain marked by COMPASS-associated histone H3 trimethylation NPM1-mutant samples. Profiling three-dimensional...
Glioblastoma multiforme remains one of the most devastating human malignancies because its high infiltrative capacity. This study aimed to investigate effects silibinin on glioblastoma U87MG cells. The microculture tetrazolium test, bromodeoxyuridine cell proliferation assay, cell-based nuclear factor kappa B (NF-[kappa]B) activation assessment, cathepsin activity gelatin zymography, and quantitative real-time reverse transcription-PCR were performed appraise metabolic activity, DNA...
Abstract Hepatocellular carcinoma (HCC) is the most common sort of primary liver malignancy with poor prognosis. This study aimed at examining effects silibinin (a putative antimetastatic agent) on some transcriptional markers mechanistically related to HCC recurrence and metastasis in HepG-2 [hepatitis B virus (HBV)-negative P53 intact) PLC/PRF/5 (HBV-positive mutated) cells. The expression 27 genes response was evaluated by real-time RT-PCR. MMP gelatinolytic assay microculture tetrazolium...
ErbB-3 and its ligand NRG-1β are key players in driving oncogenic signaling resistance to therapy through the activation of PI3K/Akt pathway. We have recently reported that EV20, a humanized anti-ErbB3 antibody, possesses marked antitumor activity variety human tumor models, including pancreatic cancer (PC). Here, we report despite epidermal growth factor receptor overexpression, PC cells more sensitive than EGF terms Akt cell proliferation. Using stable ErbB-3-knocked down EV20 combination...
The use of high-dose interleukin-2 (IL-2) has fallen out favor due to severe life-threatening side effects. We have recently described a unique way directly targeting IL-2 cytotoxic lymphocytes using virally encoded immune evasion protein and an mutant that avoids off-target effects such as activation regulatory T cells vascular endothelium.
PURPOSE Persistent molecular disease (PMD) after induction chemotherapy predicts relapse in AML. In this study, we used whole-exome sequencing (WES) and targeted error-corrected to assess the frequency mutational patterns of PMD 30 patients with MATERIALS AND METHODS The study cohort included adult AML younger than 65 years who were uniformly treated standard chemotherapy. Tumor/normal WES was performed for all at presentation. analysis evaluated bone marrow samples obtained during...
Epithelial ovarian cancer (EOC) is the most fatal gynecological malignancy due to its high proliferative and invasive capacities. A heregulin (HRG)/HER3 autocrine loop increases metastatic properties of EOC cells, suggesting that modulators this signaling pathway may prove effective trammel growth motility these cells. This study aimed evaluate effects multi-tyrosine kinase inhibitor silibinin on characteristics cell lines OVCAR8 SKOV3 through suppression HRG/HER3 pathway. To achieve this,...
New Findings What is the central question of this study? The role FGF21 as an exercise‐induced myokine remains controversial. aim study was to determine whether eccentric exercise would augment release and/or its regulatory enzyme, fibroblast activation protein α (FAP), from skeletal muscle tissue into systemic circulation healthy human volunteers. main finding and importance? Eccentric does not total or bioactive muscle. However, releases FAP, tissue(s) other than muscle, which might play a...
Increasing skeletal muscle carnitine availability alters metabolism during steady‐state exercise in healthy humans. We investigated whether elevating carnitine, and thereby the acetyl‐group buffering capacity, altered metabolic physiological adaptations to 24 weeks of high‐intensity interval training ( HIIT ) at 100% maximal capacity (Watt max ). Twenty‐one male volunteers (age 23±2 years; BMI 24.2±1.1 kg/m 2 performed × 3 minute bouts cycling Watt , separated by 5 minutes rest. Fourteen...
Background and Purpose: Oropharyngeal candidiasis (OPC) is a fungal infection of the oral cavity caused by members C. albicans complex. Although africana, as part complex, considered to be mostly responsible for development vulvovaginal candidiasis, it may associated with wider clinical spectrum. Case report: This report described two cases diagnosed during receipt treatment malignancies. Conventional molecular tests were performed on samples collected from patients’ cavities. The test...