A5064778795- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Angiogenesis and VEGF in Cancer
- Animal Disease Management and Epidemiology
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Adipose Tissue and Metabolism
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Poxvirus research and outbreaks
- Muscle Physiology and Disorders
- Tuberculosis Research and Epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Inflammatory Bowel Disease
- Ubiquitin and proteasome pathways
- Invertebrate Immune Response Mechanisms
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Viral gastroenteritis research and epidemiology
- Calcium signaling and nucleotide metabolism
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
2020-2024
University of Milan
2022
Marche Polytechnic University
2014-2016
University of Chieti-Pescara
2011-2014
Sapienza University of Rome
2014
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2011
Ghrelin is an acylated peptidyl gastric hormone acting on the pituitary and hypothalamus to stimulate appetite, adiposity, growth release, through activation of secretagogue receptor (GHSR)-1a receptor. Moreover, ghrelin features several activities such as inhibition apoptosis, regulation differentiation, stimulation or proliferation cell types. acylation absolutely required for both GHSR-1a binding its central endocrine activities. However, unacylated form, des-acyl ghrelin, which does not...
Diacylglycerol kinases (DGKs) metabolize diacylglycerol to phosphatidic acid. In T lymphocytes, DGKα acts as a negative regulator of TCR signaling by decreasing levels and inducing anergy. this study, we show that upon costimulation the with CD28 or lymphocyte activation molecule (SLAM), DGKα, but not DGKζ, exits from nucleus undergoes rapid regulation its enzymatic activity. Inhibition is dependent on expression SAP, an adaptor protein mutated in X-linked lymphoproliferative disease, which...
ErbB-3 (HER-3) receptor is involved in tumor progression and resistance to therapy. Development of specific inhibitors impairing the activity an attractive tool for cancer therapeutics. MP-RM-1, a murine monoclonal antibody targeting human ErbB-3, has shown anticancer preclinical models. With aim provide novel candidates clinical use, we have successfully generated humanized version MP-RM-1. The antibody, named EV20, abrogates both ligand-dependent ligand-independent signaling several cell...
Accumulating evidence indicates that serum and tissue levels of lectin, galactoside-binding soluble 3 binding protein (LGALS3BP), a secreted glycoprotein, are elevated in human cancers. Recently, we have identified LGALS3BP as factor capable stimulating angiogenesis microvascular endothelial cells vitro well vivo. However, the potential therapeutic implications function blockade not been explored yet. Here, tested ability an anti-LGALS3BP mouse monoclonal antibody, SP-2, to antagonize...
Diacylglycerol kinases (Dgk) phosphorylate diacylglycerol (DG) to phosphatidic acid (PA), thus turning off and on, respectively, DG-mediated PA-mediated signaling pathways. We previously showed that hepatocyte growth factor (HGF), vascular endothelial factor, anaplastic lymphoma kinase activate Dgkα in leukemia cells through a Src-mediated mechanism activation of is required for chemotactic, proliferative, angiogenic vitro. Here, we investigate the downstream events pathways regulated by...
Epizootic haemorrhagic disease (EHD), caused by the EHD virus (EHDV), is a vector-borne viral transmitted through Culicoides biting midges. EHDV comprises seven serotypes (1, 2, and 4-8), with EHDV-8 having recently emerged spread in Europe over last two years. Such event has raised concerns about significant threat posed to livestock industry. In this study, an inactivated vaccine against (vEHDV8-IZSAM) was developed. Safety efficacy of were evaluated calves clinical, serological,...
Few data exist regarding the long-term effectiveness of golimumab in ulcerative colitis. No have been reported on real-world continuous clinical response.This study aimed to describe outcomes a large cohort patients who had colitis.Consecutive with active colitis, started golimumab, were enrolled and prospectively followed up. The primary end point was evaluate persistence therapy.A total 173 colitis studied. Of these, 79.2% steroid dependent, 46.3% naïve anti-tumour necrosis factor alpha...
Bluetongue (BT) is non-contagious, vector-borne viral disease of domestic and wild ruminants, transmitted by midges (Culicoides spp.) caused virus (BTV). BTV the type species Orbivirus genus within Reoviridae family possesses a genome consisting 10 double-stranded RNA segments encoding 7 structural 4 nonstructural proteins. Viral Protein (VP7) major sera group-specific protein good antigen candidate for immunoenzymatic assays BT diagnosis. In our work, BTV-2 recombinant VP7 (BTV-2 recVP7),...
Background: Lumpy skin disease virus (Poxviridae family—Capripoxvirus genus) is the aetiological agent of LSD, a primarily transmitted by hematophagous biting, affecting principally cattle. Currently, only live attenuated vaccines are commercially available, but their use limited to endemic areas. There need for safer vaccines, especially in LSD-free countries. This research aims develop and test safe efficacious inactivated vaccine. Moreover, this study, we used keyhole limpet hemocyanin...
Abstract Background: Pancreatic cancer (PC) is one of the most lethal cancers and there an urgent need to find out new therapeutic approaches. Deregulated signaling through ErbB-1 ErbB-2, members epidermal growth factor receptor family, frequently occurs in PC. However, attempts aiming at inhibiting ErbB-2 have revealed only a modest impact on disease outcome. A growing body evidence suggests that ErbB-3 its ligand NRG-1β are key players driving oncogenic resistance targeted therapy We...
Abstract Background: The signaling network downstream of the human epidermal growth factor receptors ErbB-1 and ErbB-2 have been extensively targeted by cancer therapeutics. Although initially efficacious in a subset patients, drugs targeting these led invariably to resistance which is often associated with reactivation ErbB-3/PI3K-Akt axis. This may be overcome ErbB-3 ligands that abrogates receptor-mediated signaling. Methods: murine MP-RM-1 monoclonal antibody specifically binds...
e13538 Background: The ErbB receptors, such as ErbB-1 and ErbB-2, have been intensely pursued targets for cancer therapeutics. Although initially efficacious in a subset of patients, drugs targeting these receptors led invariably to resistance which is often associated with reactivation the ErbB-3-PI3K-Akt signaling. This may be overcome by an ErbB-3 ligand binding molecule that abrogates mediated Methods: we generated mouse monoclonal antibody, MP-RM-1, against extracellular domain (ECD)...
In this report, we describe eight complete genome sequences of African horse sickness virus (AHSV) strains belonging to four different serotypes, namely, AHSV-5, AHSV-6, AHSV-8, and AHSV-9. Samples were collected in Namibia South Africa from infected horses between 2000 2011. As expected, phylogenetic analyses the variable outer capsid protein VP2 genomic AHSV-6 AHSV-8 show higher nucleotide identity isolated viruses than that relevant reference strains. The full-genome sequence AHSV will...
<div>Abstract<p>Accumulating evidence indicates that serum and tissue levels of lectin, galactoside-binding soluble 3 binding protein (LGALS3BP), a secreted glycoprotein, are elevated in human cancers. Recently, we have identified LGALS3BP as factor capable stimulating angiogenesis microvascular endothelial cells <i>in vitro</i> well vivo</i>. However, the potential therapeutic implications function blockade not been explored yet. Here, tested ability an...
<p>PDF file - 48KB, SP-2 inhibits growth of ovarian cancer and melanoma xenografts.</p>
<p>PDF file - 67KB</p>
<div>Abstract<p>Accumulating evidence indicates that serum and tissue levels of lectin, galactoside-binding soluble 3 binding protein (LGALS3BP), a secreted glycoprotein, are elevated in human cancers. Recently, we have identified LGALS3BP as factor capable stimulating angiogenesis microvascular endothelial cells <i>in vitro</i> well vivo</i>. However, the potential therapeutic implications function blockade not been explored yet. Here, tested ability an...
<p>PDF file - 48KB, SP-2 inhibits growth of ovarian cancer and melanoma xenografts.</p>