A5086389231- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Advanced Image Processing Techniques
- Cancer Research and Treatments
- Medical Device Sterilization and Disinfection
- Systemic Sclerosis and Related Diseases
- Advanced X-ray Imaging Techniques
- Glycosylation and Glycoproteins Research
- Endoplasmic Reticulum Stress and Disease
- Analytical Chemistry and Chromatography
- Spectroscopy Techniques in Biomedical and Chemical Research
- Proteoglycans and glycosaminoglycans research
Maastricht University
2016-2021
Icometrix (Belgium)
2018
Mass Spectrometry Imaging (MSI) is an established and powerful MS technique that enables molecular mapping of tissues cells finding widespread applications in academic, medical, pharmaceutical industries. As both the MSI technology have undergone rapid growth improvement, challenges associated with analyzing large datasets identifying many detected species become apparent. The lack readily available comprehensive software covering all necessary data analysis steps has further compounded this...
BACKGROUND. Although aberrant glycosylation is recognized as a hallmark of cancer, in clinical breast cancer (BC) metastasis has not yet been studied. While preclinical studies show that the glycocalyx coating cells involved adhesion, migration, and metastasis, changes from primary tumor (PT) to various metastatic sites remain unknown patients.
Abstract The large‐scale and label‐free molecular characterization of single cells in their natural tissue habitat remains a major challenge biology. We present method that integrates morphometric image analysis to delineate classify individual with single‐cell‐specific profiles. This approach provides new means study spatial biological processes such as cancer field effects the relationship between features.
Hepatocellular lipid accumulation characterizes nonalcoholic fatty liver disease (NAFLD). However, the types of lipids associated with progression are debated, as is impact their localization. Traditional lipidomics analysis using homogenates or plasma dilutes and averages concentrations, does not provide spatial information about distribution. We aimed to characterize distribution specific species related NAFLD severity by performing label-free molecular mass spectrometry imaging (MSI)....
Abstract Mass spectrometry imaging (MSI) and histology are complementary analytical tools. Integration of the two modalities can enhance spatial resolution MSI beyond its experimental limits. Patch-based super (PBSR) is a method where high features from one image modality guide reconstruction low second modality. The principle PBSR lies in redundancy aims at finding similar pixels neighborhood central pixel that then used to pixel. In this work, we employed increase MSI. We validated...
Abstract The large‐scale and label‐free molecular characterization of single cells in their natural tissue habitat remains a major challenge biology. We present method that integrates morphometric image analysis to delineate classify individual with single‐cell‐specific profiles. This approach provides new means study spatial biological processes such as cancer field effects the relationship between features.