A5079906205- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Glycosylation and Glycoproteins Research
- Helicobacter pylori-related gastroenterology studies
- Polysaccharides Composition and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Biosensing Techniques and Applications
- Dysphagia Assessment and Management
- Immunotherapy and Immune Responses
- Esophageal Cancer Research and Treatment
- Cell Adhesion Molecules Research
- Molecular Biology Techniques and Applications
- Respiratory and Cough-Related Research
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Skin and Cellular Biology Research
- Ion Channels and Receptors
- Virus-based gene therapy research
- Congenital gastrointestinal and neural anomalies
- Plant Virus Research Studies
Camden and Campbelltown Hospitals
2017-2025
Western Sydney University
2017-2025
Yale University
2016-2025
Systems Biology Institute
2024
Yale Cancer Center
2023
Yale New Haven Health System
2023
University of Illinois Chicago
2023
Scripps Research Institute
2022
Baylor College of Medicine
2022
The University of Sydney
2009-2017
Abstract The emergence of SARS-CoV-2 variants concern has prompted the need for near real-time genomic surveillance to inform public health interventions. In response this need, global scientific community, through unprecedented effort, sequenced and shared over 10 million genomes GISAID, as May 2022. This extraordinarily high sampling rate provides a unique opportunity track evolution virus in real-time. Here, we present outbreak.info , platform that currently tracks 40 combinations PANGO...
Non-erosive reflux disease (NERD) and esophageal adenocarcinoma (EAC) are often regarded as bookends in the gastroesophageal spectrum. However, there is limited clinical evidence to support this paradigm while underlying mechanisms of progression remain unclear. In study, we used 16S rRNA sequencing mass-spectrometer-based proteomics characterize microbiota host mucosa proteome, respectively. A total 70 participants from four patient groups (NERD, esophagitis, Barrett’s esophagus, EAC) a...
The pleiotropic effects of human disease and the complex nature gene-interaction networks require knock-in mice allowing for multiplexed gene perturbations. Here we describe a series with C57BL/6 background conditional or constitutive expression LbCas12a high-fidelity enhanced AsCas12a, which were inserted at Rosa26 locus. Cas12a in did not lead to discernible pathology enabled efficient genome engineering. We used retrovirus-based immune-cell engineering CD4+ CD8+ T cells, B cells...
Motility disorders are prevalent, often leading to disrupted regional or whole gut transit times. In this study, we conducted a comparative analysis between the wireless motility capsule and an innovative gas-sensing evaluate times in individuals with diagnosed disorders.
Abstract The emergence of SARS-CoV-2 variants concern has prompted the need for near real-time genomic surveillance to inform public health interventions. In response this need, global scientific community, through unprecedented effort, sequenced and shared over 11 million genomes GISAID, as May 2022. This extraordinarily high sampling rate provides a unique opportunity track evolution virus in real-time. Here, we present outbreak.info, platform that currently tracks 40 combinations PANGO...
The low socioeconomic region of Greater Western Sydney (GWS) has higher than average rates gastrointestinal symptoms. relationship between prescription drug usage and constipation not been explored. aim this study was to investigate the impact use on in elderly population GWS (NSW, Australia). A random selection residents completed a postal questionnaire for (response 30.7%). Bivariate associations number with adverse effect were compared. For multivariate analysis multiple logistic...
The current prognosis and classification of CRC relies on staging systems that integrate histopathologic clinical findings. However, in the majority cases, cell dysfunction is result numerous mutations modify protein expression post-translational modification1. A number surface antigens, including cluster differentiation (CD) have been identified as potential prognostic or metastatic biomarkers CRC. These antigens make ideal their often changes with tumour progression interactions other...
Home-based healthcare provides a viable and cost-effective method of delivery for resource- labour-intensive therapies, such as rehabilitation including anorectal biofeedback. However, existing systems home biofeedback are not able to monitor patient compliance or assess the quality exercises performed, result have yet see wide spread clinical adoption. In this paper, we propose new Internet Medical Things (IoMT) system provide home-based therapy, facilitating remote monitoring by physician....
Dietary fibres are an integral part of a balanced diet. Consumption high-fibre diet confers many physiological and metabolic benefits. However, fibre is generally avoided by individuals with gastrointestinal motility disorders like gastroparesis due to increased likelihood exacerbated symptoms. Low-viscosity soluble have been identified as possible source tolerable for these individuals. The aim this study determine the rheological properties 10 common commercially available in chemically...
Cas9 transgenic animals have drastically accelerated the discovery of novel immune modulators. But due to its inability process own CRISPR RNAs (crRNAs), simultaneous multiplexed gene perturbations using remains limited, especially by pseudoviral vectors. Cas12a/Cpf1, however, can concatenated crRNA arrays for this purpose. Here, we created conditional and constitutive LbCas12a knock-in mice. With these mice, demonstrated efficient editing surface protein knockdown within individual primary...
Gastroesophageal reflux disease (GORD) is caused by gastric contents refluxing back into the oesophagus and oral cavity. It can lead to injuries mucosa in form of erosion ulcers. Our past research have shown acid severity progression associated with alternations microbiota distal oesophagus. The aim this study was explore whether changes occurred GORD patients establish any associations severity.
Gastroparesis is a motility disorder that causes severe gastric symptoms and delayed emptying, where the majority of sufferers are females (80%), with 29% also diagnosed Type-1 or Type-2 diabetes. Current clinical recommendations involve stringent dietary restriction includes avoidance minimization fibre. Dietary fibre lowers glycaemic index food, reduces inflammation provides laxation. Lack in diet can affect long-term gastrointestinal health. Our previously published rheological study...
"Soluble" type dietary fibre contains polysaccharides with monomer constituents that play a major role in lowering the glycemic index of food ("low-GI") and improving colonic health through gut microbiome fermentation. Soluble fibres such as partially hydrolysed guar gum (PHGG), Arabic psyllium husk are particular interest gastrointestinal research, exploring their effects motility disorders gastroparesis, constipation, diarrhea irritable bowel syndrome (IBS) is important. The primary aim...
Anticholinergic drugs are well-known to cause adverse effects, such as constipation, but their effects on baseline contractile activity in the gut driven by slow waves is not well established. In a video-based gastrointestinal motility monitoring (GIMM) system, mouse's small intestine was placed Krebs solution and recorded using high definition camera. Untreated controls were for each specimen, then treated with therapeutic concentration of drug, finally, supratherapeutic dose drug. Next,...