A5063726565- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Donation and Transplantation
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Clinical Nutrition and Gastroenterology
- Liver Diseases and Immunity
- Transplantation: Methods and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis C virus research
- Gut microbiota and health
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Gallbladder and Bile Duct Disorders
- Chromatin Remodeling and Cancer
- Statistical Methods in Clinical Trials
- Cancer Genomics and Diagnostics
- Vagus Nerve Stimulation Research
- Diet and metabolism studies
- Genetic and Kidney Cyst Diseases
- Anesthesia and Sedative Agents
University of Padua
2014-2025
Azienda Ospedaliera di Padova
2021
Yale University
2016-2017
To fully harness mesenchymal-stromal-cells (MSCs)' benefits during Normothermic Machine Perfusion (NMP), we developed an advanced NMP platform coupled with a MSC-bioreactor and investigated its bio-molecular effects clinical feasibility using rat porcine models. The study involved three work packages: 1) Development (n = 5): MSC-bioreactors were subjected to 4 h-liverless perfusion; 2) Rat model 10): livers perfused for h on the MSC-bioreactor-circuit or standard platform; 3) Porcine 6):...
Antioxidant agents have the potential to reduce ischemia/reperfusion damage organs for liver transplantation (LT). In this prospective, randomized study, we tested impact of an infusion N-acetylcysteine (NAC) during procurement on post-LT outcomes. Between December 2006 and July 2009, 140 grafts were transplanted into adult candidates with chronic disease who listed first LT, according a sequential, closed-envelope, single-blinded procedure, these patients randomly assigned in 1/1 ratio NAC...
Early everolimus (EVR) introduction and tacrolimus (TAC) minimization after liver transplantation may represent a novel immunosuppressant approach. This phase 2, multicenter, randomized, open-label trial evaluated the safety efficacy of early EVR initiation. Patients treated with corticosteroids, TAC, basiliximab were randomized (2:1) to receive (1.5 mg twice daily) on day 8 gradually minimize or withdraw TAC when was stable at >5 ng/mL continue 6-12 ng/mL. The primary endpoint proportion...
Abstract Background: Videolaparoscopic (VL) microwave ablation (MWA) is not included in most of the international guidelines as a therapeutic option for hepatocellular carcinoma (HCC). Aim this study was to assess safety VL MWA patients with HCC whom resection or percutaneous unsuitable. Methods: A retrospective analysis performed on prospective database treated at our institution from 2009 2016. Patient demographics, operational characteristics, and complications were recorded. Statistical...
Sorafenib is acknowledged as the standard therapy for advanced hepatocellular carcinoma (HCC) but in clinical practice treatment of these patients extremely complex and needs to be personalized. New evidence suggests that surgical resection-based multimodal treatments may improve outcome patients. There no strong supporting ability sorafenib downstage HCC before surgery. We presented a case 53-year-old man with well-compensated HCV-cirrhosis complicated neoplastic portal vein thrombosis. The...
Background: Butyrate protects against ischemic injury to the small intestine by reducing inflammation and maintaining structure of intestinal barrier, but is expensive, short-lived, cannot be administered easily due its odor. Lactate, both economical more palatable, can converted into butyrate microbiome. This study aimed assess in a rat model whether lactate perfusion also protect ischemia. Materials Methods: Rat segments were loaded an vitro bowel device, water absorption or secretion was...
The possibility of keeping liver grafts viable and functioning until transplantation has been explored since the 1950s. However, current modalities Normothermic Machine Perfusion (NMP) have shown several limitations, such as inability to correct electrolytes pH derangements efficiently. Combining NMP with continuous kidney replacement therapy (CKRT) might provide a promising new model overcome these issues.
In the context of spreading interest in textbook outcome (TO) evaluation different fields, we aimed to investigate an uncharted procedure, that is, laparoscopic microwave ablation (MWA) for hepatocellular carcinoma (HCC). Absence post-MWA complications, a hospital stay three days, no mortality nor readmission within 30 and complete response target lesion at CT scan defined TO achievement. Patients treated between January 2014 March 2021 were retrospectively reviewed, 521 patients eligible...
Hemoperitoneum is a possible complication of hepatocellular carcinoma that may require emergency surgery as an alternative to radiological locoregional therapies. We present case report 78-year-old white man with alcoholic-related cirrhosis and multifocal carcinoma. An abdominal computed tomography scan showed multiple bilateral foci bleeding from broken liver cancer. He was urgently transferred our radiology unit operating room for massive hemoperitoneum. A middle line laparotomy detected...
The XXL trial represents the first prospective validation of “biological downstaging” in liver transplantation (LT) for hepatocellular carcinoma. aim this study was to compare Padua downstaging protocol terms failure rates and patient outcome. A total 191 patients undergoing aggressive surgical potentially eligible LT from 2012 2018 at our center were retrospectively selected according criteria. Unlike trial, with a complete response did not receive any prioritization LT. Downstaging defined...
Objective: Historically, bile in the biliary tract has been considered sterile. Most of series are based on patients with diseases or obtained procedures susceptible to contamination. Methods: We evaluated a heterogeneous cohort liver donors and recipient patients, samples sterile way, directly from gallbladder common duct. Results: assessed microbiota six recipients after whole split adult pediatric recipients. Bile were studied using PCR sequencing 16S ribosomal RNA gene amplification...
Surgical site infections (SSI) are a significant cause of morbidity in liver transplant recipients, and the current data pediatric population limited. The goal this study was to identify incidence, classification, risk factors, outcomes SSIs among children undergoing transplantation (LT).A single-center, retrospective descriptive analysis performed patients age ≤18 years LT between September 2007 April 2017. SSI identified within first 30 days were analyzed. Primary endpoints included...
Background: Liver resection represents the first curative treatment to treat primary and secondary hepatic tumors. Thoracoscopic liver ablation is a viable minimally invasive alternative treatment, especially for patients with previous multiple abdominal surgeries. The aim of study was evaluate safety efficacy thoracoscopic Methods: Retrospective analysis prospective database tumors, treated trans-diagrammatic (MWA or RFA) at our institution from 2012 2018. endpoint post-operative mortality...