Tumor microenvironment-induced ultrasmall nanodrug generation (TMIUSNG) is an unprecedented approach to overcome the drug penetration barriers across complex biological systems, poor circulation stability and limited loading efficiency (DLE). Herein, a novel strategy was designed synthesize metal–organic complexes (MONCs) through supramolecular coassembly of photosensitizer sinoporphyrin sodium, chemotherapeutic doxorubicin ferric ions. Compared with free photosensitizer, MONCs produced...

Nerve conduits have been identified as one of the most promising treatments for peripheral nerve injuries, yet it remains unsolved how to develop ideal with both appropriate biological and mechanical properties. Existing must make trade-offs between strength biocompatibility. Here, we propose a multi-nozzle additive-lathe 3D bioprinting technology fabricate bilayered conduit. The materials printing consisted gelatin methacrylate (GelMA)-based inner layer, which was cellularized bone marrow...

As the richest aromatic renewable resource, lignin has attracted significant attention for fabricating various materials.

Abstract The lattice dynamics of high Al composition semiconductor alloy, 0.86 Ga 0.14 N, in comparison with the intrinsic GaN and AlN are studied by Stokes/anti-Stokes Raman spectroscopy temperature range 85~823 K. phonon anharmonic effect N is found to be stronger than GaN, revealing low thermal conductivity alloy. multi-phonon coupling behavior analyzed both Stokes anti-Stokes spectroscopy. It interesting find that scattering exhibits three-phonon as compared scattering, which may due...

This article explores the historical trajectory and cultural integration of Chinese immigrants in Peru, tracing their journey from era coolie labor mid-19th century to modern-day contributions Peruvian society. The study examines socio-economic political factors that facilitated large-scale migration, particularly enactment Law 1849 subsequent phases immigration. research also highlights harsh conditions faced by workers, struggles for survival adaptation, eventual assimilation into society...

With the rapid advancement of machine learning (ML) technologies, their innovative applications in enhancing building energy efficiency are increasingly prominent. Utilizing tools such as VOSviewer and Bibliometrix, this study systematically reviews body related literature, focusing on key emerging trends cutting-edge ML techniques, including deep learning, reinforcement unsupervised optimizing performance managing carbon emissions. First, paper delves into role prediction, intelligent...

This article considers the order batching problem in steelmaking and continuous-casting production. The is to jointly specify slabs needed satisfy each customer group all of different orders into production batches. A novel mixed integer programming model formulated for problem. Through relaxing assignment constraints, a Lagrangian relaxation then obtained. By exploiting relationship between column generation, we develop combined algorithm that contains nested double loops. At inner loop,...

Phase change energy storage wood (PCESW) was prepared by using microencapsulated phase materials (MicroPCM) as thermal (TES) and the matrix. The incorporation of MicroPCM realized a vacuum impregnation method. morphology microstructure MicroPCM, delignified (DLW) PCESW were observed scanning electron microscopy (SEM); properties including temperature, enthalpy, stability, conductivity characterized differential calorimetry (DSC), thermogravimetric analysis (TG) laser flash (LFA). results...

Qin Liu, Rui Zheng, Bao Rong, Jingyi ZhiHua Zhanzhan Cheng, Liang Qiao, Tao Gui, Qi Zhang, Xuanjing Huang. Proceedings of the 60th Annual Meeting Association for Computational Linguistics (Volume 1: Long Papers). 2022.

Abstract Tubular scaffolds serve as a controllable extracellular environment to guide the repair and regeneration of tissues. But it is still challenge achieve both excellent mechanical properties cell compatibility artificial for long-term structural biological stability. In this study, four-step solution casting method was developed fabricate dual-layer cell-laden tubular nerve bile duct regeneration. The scaffold consisted bone marrow mesenchymal stem cells (BMSCs)-laden hydrogel inner...

The combined use of magnetic resonance/photoacoustic imaging techniques is useful in monitoring vascular permeability and temperature status following nanoparticle-mediated photothermal therapy.

Recently, 3D bioprinting is developed as an emerging approach, increasingly applied to materials for healthcare; while, the precise placement of cells and materials, shape fidelity forming constructs great importance successful application bioprinting. Research efforts have been made develop new bioinks "raw materials" with better biocompatibility biofunctionality, but printability largely ignored still needs be carefully examined enable robotic This article aims introduce a recent published...

Ciliated microorganisms near the base of aquatic food chain either swim to encounter prey or attach at a substrate and generate feeding currents capture passing particles. Here, we represent attached swimming ciliates using popular spherical model in viscous fluid with slip surface velocity that afford analytical expressions ciliary flows. We solve an advection-diffusion equation for concentration dissolved nutrients, where P'eclet number (Pe) reflects ratio diffusive advective time scales....

In the hot continuous rolling process, main factor affecting actual thickness of strip is force. The precision force calculation key to realize accurate on‐line control. However, because complexity and nonlinearity as well many influencing factors, theoretical analysis traditional prediction model often needs be simplified hypothesized. This leads incompleteness mathematical deviation between calculated results working conditions. this paper, a method based on genetic algorithm (GA),...

Abstract In this work, a novel phase change energy storage wood (PCESW) was fabricated by impregnating solid-solid materials (SSPCM) into delignified wood. The SSPCM prepared using polyethylene glycol (PEG) 1500 as the thermal ingredient, hexamethylene diisocyanate (HDI) cross-linking agent and castor oil (CO) skeleton material. chemical composition structure of PCESW were confirmed fourier transform infrared spectroscopy (FTIR); crystalline PEG tested x-ray diffraction (XRD); microstructure...

With the improvement of industrial requirements for quality cold rolled strips, flatness has become one most important indicators measuring strips. In this paper, strip production data a 1250 mm tandem mill in steel plant is modeled by an improved deep neural network (the DNN) to improve accuracy shape prediction. Firstly, type activation function analyzed, and monotonicity deemed independent convexity loss network. Regardless whether monotonic, not strictly convex. Secondly, non-convex...

This article presents a study to evaluate the performance of ecofriendly calcium sulfate whisker fiber- (CSWF-) reinforced asphalt mixture as sustainable pavement material. Asphalt mixtures containing 0.2 wt.%, 0.4 0.6 and 0.8 wt.% CSWF were designed by Marshall method. without fiber also prepared control samples. The test, wheel-tracking low-temperature bending water sensitivity fatigue test conducted mixture. And mechanism reinforcement was discussed. results showed that could improve...

The fiber structures of tumor microenvironment (TME) are well-known in regulating cell behaviors, and the plastic remolding TME has recently been suggested to enhance metastasis as well. However, interrelationship between microarchitecture matrix plasticity is inextricable by existing vitro models. individual roles tuning behaviors remain elusive. This study develops an interpenetrating collagen-alginate hydrogel platform with independently tunable through strategy alginate networks collagen...