A5101437061- Hip and Femur Fractures
- Clinical Nutrition and Gastroenterology
- Clostridium difficile and Clostridium perfringens research
- Osteoarthritis Treatment and Mechanisms
- Bat Biology and Ecology Studies
- Orthopaedic implants and arthroplasty
- Animal Behavior and Reproduction
- Animal Vocal Communication and Behavior
- Gut microbiota and health
- Hip disorders and treatments
- Advanced biosensing and bioanalysis techniques
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Chemokine receptors and signaling
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- SARS-CoV-2 detection and testing
- Acute Kidney Injury Research
- Cell death mechanisms and regulation
- Tea Polyphenols and Effects
Okayama University
2022-2024
First Affiliated Hospital of Zhengzhou University
2022-2023
Zhengzhou University
2023
Nanjing Drum Tower Hospital
2023
Fujian Agriculture and Forestry University
2023
Shanxi Medical University
2016-2022
Second Hospital of Shanxi Medical University
2016-2022
University of Electronic Science and Technology of China
2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Cell death and inflammation in the proximal tubules are hallmarks of cisplatin-induced AKI, but mechanisms underlying these effects have not been fully elucidated. Here, we investigated whether necroptosis, a type programmed necrosis, has role AKI. We found that inhibition any core components necroptotic pathway—receptor-interacting protein 1 (RIP1), RIP3, or mixed lineage kinase domain-like (MLKL)—by gene knockout chemical inhibitor diminished tubule damage mice. Similar results were...
Increased evidence shows that gut microbiota acts as the primary regulator of liver; however, its role in sepsis-related liver injury (SLI) elderly is unclear. This study assessed whether metformin could attenuate SLI by modulating septic-aged rats. Cecal ligation and puncture (CLP) was used to induce aged Fecal transplantation (FMT) validate roles these pathologies. The composition analysed 16S rRNA sequencing. Moreover, colon tissues were histopathology, immunofluorescence,...
The death of cells elicited by NLRC4 inflammasome overactivation plays a decisive role in lethal outcome the mice.
We developed a label-free homogeneous photoelectrochemical biosensing strategy based on the synergy of G-quadruplex/hemin catalysed electron donor consumption and inner filter effect for highly selective sensitive microRNA assay.
Chemokine stromal cell-derived factor-1 (SDF-1) is a powerful chemoattractant for the localization of CXCR4-positive bone marrow mesenchymal stem cells (BMSCs) into marrow. We studied effects SDF-1 on cartilage defect repair by recruiting BMSCs and promoting its chondrogenic differentiation in vitro vivo. Chemotaxis analysis with Transwell plate showed that could recruit through SDF-1/CXCR4 axis. Real-time polymerase chain reaction, enzyme-linked immunosorbent assays, Western blot results...
Abstract Background Patients with triple-negative breast cancer (TNBC) often have poorer prognosis than those other subtypes because of its aggressive behaviors. Cancer cells are heterogeneous, and only a few highly metastatic subclones metastasize. Although the majority may not metastasize, they could contribute by releasing factors that increase capacity and/or provide favorable tumor microenvironment (TME). Here, we analyzed interclonal communication in TNBC which leads to efficient...
Excess iron is known to be a risk factor of carcinogenesis. Although chelators show anti-cancer effects, they have not been used successfully treat cancer patients. Triple-negative breast (TNBC) disease with poor prognosis without effective treatments. Thus, we aimed evaluate possibility as therapy for TNBC. Deferasirox (DFX), an chelator, suppressed the growth 4T1 murine TNBC cell line cells in vitro and vivo. Lung metastasis was further significantly reduced, leading hypothesis that...
Abstract Background Huangjingui ( Camellia sinensis )，a kind of oolong tea, is native to Anxi County, Fujian Province, China, and a national tea tree species. Tea processing the key link in formation its aroma characteristics, it important analyze influence each process on intensity odor characteristics order optimize improve quality tea. Results The favored accumulation volatile compounds as evidenced by increase their content from 9.793 123.052 μg/kg, which highest was mainly terpenoids,...
The epidermal growth factor receptor (EGFR) is an important therapeutic target for patients with non-small-cell lung cancer (NSCLC). Radiomics and radiogenomics have emerged as attractive research topics aiming to extract mineable high-dimensional features from medical images show potential correlate the gene mutation. Herein, we aim develop a magnetic resonance imaging (MRI)-based radiomics model pretreatment prediction of EGFR status in adenocarcinoma.A total 92 pathologically confirmed...
Genetic and ecological factors influence morphology, morphology is compatible with function. The bite performance of skulls bats show a number characteristic feeding adaptations. great evening bat, Ia io (Thomas, 1902), eats both insects birds (Thabah et al. J Mammal 88: 728-735, 2007), as such, it considered to represent case dietary niche expansion from birds. How the skull or force in I. are related expanded diet (that is, birds) remains unknown. We used three-dimensional (3D) geometry...
Femoral neck fractures are a common traumatic injury. The removal of the internal fixation remains controversial, especially in terms mechanical stability. Moreover, collapsed necrosis femoral head continues to occur after fracture healing. We believe that sclerotic cancellous bone (SCB) formation around screw is associated with necrosis. aimed compare features before and implant determine effect SCB on stress distribution.Cylindrical sections were collected from relatively normal region an...
Multiplex, rapid and accurate virus quantification plays a great value in biomedical detection. Here, novel one step, wash-free immunoassay platform based bioinspired PhC barcodes for multiplexed was explored. were decorated with PDA by self-polymerization of DA, thus this nanocomposite hybridized facilitated the adsorption FITC labelled antibodies quenched itself photoluminescent, allowing fast responsive composite platform. In presence target analyte, FITC-labelled detection antibody...
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. However, there still no single drug that could reduce septic mortality. Previous studies have reported gabexate mesylate (GM) significantly reduced serum inflammatory factors, alleviated sepsis-induced lung injury and improved clinical outcomes. This study aimed combine with microbiome sequencing metabolomics analysis explore the effects of GM administration in rats.Sixty SD rats were randomly...
Personality traits represent a leading edge in the evolutionary process, as natural selection acts directly on variations individual phenotypes within populations. Recent theoretical models have focused concept of adaptive state-dependent behavior, proposing that repeatable differences behavior emerge because state variables, such metabolic rate, age, sex, or body size. and its correlation with size, however, been relatively unexplored bats. We used female Asian particolored bats...
Abstract Social animals may cooperate to gain resources such as food and territory. However, unavoidable conflicts over limited frequently occur between group members. rank effectively decrease within animal social groups, thereby reducing energy consumption maintaining stability. In this study, we tested the two factors most often proposed influence winning a conflict: body size prior residence. Our results showed that female Asian particolored bats (Vespertilio sinensis) formed near-linear...
The food calorie estimation system (FCES) is designed to record dietary information for diabetic patients monitor their intake estimate the number of calories they are consuming.Deep learning technologies have recently been used FCESs.In this work, we use neural network pattern recognition images calculate calories.In contrast traditional convolutional network, build a semantic segmentation model based on SegNet + MobileNet segment and extract area feature images.By determining corresponding...
Sepsis is a clinical syndrome with high mortality. Subtype identification in sepsis meaningful for improving the diagnosis and treatment of patients. The purpose this research was to identify subtypes using RNA-seq datasets further explore key genes that were deregulated during development sepsis.The GSE95233 GSE13904 obtained from Gene Expression Omnibus database. Differential analysis gene expression matrix performed between patients healthy controls. Intersection differentially expressed...